Gosh, I am off Pred for almost three weeks and still got the headaches, and I know it is not from the 6-MP that I take at 6 PM. I wake up with these headaches and they ease up in the run of the day, but no luck getting rid of them. I don't want to take too much Tylenol either since it can clash with 6-MP (regarding the liver). I started to get Pred headaches at 5 mg that I took for almost 2 weeks. That leaves me now with a daily headache since 5 1/2 weeks. So I feel your pain - things can only get better. Hang in there!