Generic medicine, are they really effective?

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Yujin
Regular Member


Date Joined Feb 2008
Total Posts : 55
   Posted 1/11/2009 11:58 PM (GMT -6)   
I was taking generic Asacol which i got from India for about a year. Taking this medicine did not do any change. My doctor suggested me to take Salofalk instead. Im already taking this for a month, and  i already noticing some great improvements. I dont have any urgency, less BM and less stomach cramps.
 
Does this mean that generic medicine is NOT EFFECTIVE compared with BRANDED medicines?
Diagnosed with UC on 2007. Undergone Fistulotomy on 2005. Taking Generic Asacol 400mg 3X a day... "HEALTH IS WEALTH"


ucwarrior
Regular Member


Date Joined Jul 2008
Total Posts : 298
   Posted 1/12/2009 12:07 AM (GMT -6)   
The FDA in America requires the bioequivalence of the generic product to be between 80% and 125% of that of the name brand product. That does not mean that generic drugs must be exactly the same as their "brand name" product counterparts. Some chemical differences may exist in generic versions as opposed to the name brand version. I'm not sure about overseas product management procedures.
Diagnosed w/ Ulcerative Colitis in 1995
32 years old
Living med free  
Currently in remission  


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/12/2009 1:17 AM (GMT -6)   
Generic drugs are copies of brand-name drugs that have exactly the same dosage, intended use, effects, side effects, route of administration, risks, safety, and strength as the original drug. In other words, their pharmacological effects are exactly the same as those of their brand-name counterparts.


Many people become concerned because generic drugs are often substantially cheaper than the brand-name versions. They wonder if the quality and effectiveness have been compromised to make the less expensive products. The FDA (U.S. Food and Drug Administration) requires that generic drugs be as safe and effective as brand-name drugs.

Actually, generic drugs are only cheaper because the manufacturers have not had the expenses of developing and marketing a new drug. When a company brings a new drug onto the market, the firm has already spent substantial money on research, development, marketing and promotion of the drug. A patent is granted that gives the company that developed the drug an exclusive right to sell the drug as long as the patent is in effect.

As the patent nears expiration, manufacturers can apply to the FDA for permission to make and sell generic versions of the drug. Without the startup costs for development of the drug, other companies can afford to make and sell it more cheaply. When multiple companies begin producing and selling a drug, the competition among them can also drive the price down even further.

So there's no truth in the myths that generic drugs are manufactured in poorer-quality facilities or are inferior in quality to brand-name drugs. The FDA applies the same standards for all drug manufacturing facilities, and many companies manufacture both brand-name and generic drugs. In fact, the FDA estimates that 50% of generic drug production is by brand-name companies.

Another common misbelief is that generic drugs take longer to work. The FDA requires that generic drugs work as fast and as effectively as the original brand-name products.

Sometimes, generic versions of a drug have different colors, flavors, or combinations of inactive ingredients than the original medications. Trademark laws in the United States do not allow the generic drugs to look exactly like the brand-name preparation, but the active ingredients must be the same in both preparations, ensuring that both have the same medicinal effects.


:)
My bum is broken....there's a big crack down the middle of it! LOL :)


jujub
Elite Member


Date Joined Mar 2003
Total Posts : 10407
   Posted 1/12/2009 11:46 AM (GMT -6)   
PB is correct. There is one caveat to add: those criteria apply to drugs made in the US. Drugs manufactured in other countries may or may not be as rigidly monitored, depending on the individual country. Some countries are probably safer than the US, while others certainly control the manufacture of pharmaceuticals much less stringently.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
"My life is an ongoing medical adventure"
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5191
   Posted 1/12/2009 12:32 PM (GMT -6)   
UC patients may react differently to the generic drug for several reasons. Some of us find that generic balsalazide does not help us or makes us feel crampy, etc., whereas the original Colazal makes a big improvement in our condition. We did a thread on this recently in case you want to look it up. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/12/2009 2:09 PM (GMT -6)   
Keep in mind too that even with the brand name drugs they don't always work for everyone and of course they too have side effects.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Yujin
Regular Member


Date Joined Feb 2008
Total Posts : 55
   Posted 1/12/2009 10:16 PM (GMT -6)   
Thanks for all the info... i really appreciate it

I'am happy with the progress that im getting with Salofalk but the only problem that I'm having is that Salofalk is quite expensive here in the Philippines. It cost me 6000 pesos a month (125 US dollars) and I cant afford to supplement myself with this medicine for a lifetime. So, i wanted to know if theres a Generic Salofalk that i can order online.. I already tried looking on the web but i cant find one. I only found was the generic Asacol that i took for more than a year, which did not give me any improvement....

pls advise... tnx :)
Diagnosed with UC on 2007. Undergone Fistulotomy on 2005. Taking Generic Asacol 400mg 3X a day... "HEALTH IS WEALTH"


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5191
   Posted 1/13/2009 4:37 PM (GMT -6)   
Here in the U.S. Salofalk is called Rowasa; it is also very expensive-- about $14 per dose. However, we have been getting the generic mesalamine enemas through our pharmacies for several yrs now. They are shipped to the U.S. from Israel! If you want to look up the companies there on the Internet, one of them is called Perrigo. (I think that all the UC meds with "falk" in the name are made by a company in Germany.) Hope this info helps you out! / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])
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