Generic Asacol

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16736
   Posted 1/18/2009 11:57 AM (GMT -6)   
Sorry if this has been asked before but...
 
does anyone use the generic version of Asacol 400mg tablets? It is available in Canada but not in the US. I order from Canada and I have the option of getting generic, which would save me some money, but I am scared the generic might not help me like the brand and I will end up in the toilet 15x a day.
 
Any advice on getting the generic from Canada?
Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December but had symptoms months ago - Treating with Asacol (feel hopeless)


basa0806
Veteran Member


Date Joined Feb 2005
Total Posts : 2103
   Posted 1/18/2009 2:17 PM (GMT -6)   
The FDA requires all generic medications to be the same formula and strength as non-generic. I'm assuming Canada probably has similar stipulations. Generic just means that they don't have a patent on the active ingredient like the producers of the non-generic. At least that is what I've been able to read.
My brother had to order generic medication from Canada for a second bout with shingles and it worked just the same. If you're worried about it, maybe your GI could help you understand a little better?
Sam
20 year old college student diagnosed with ulcerative colitis at 16
Remission since January/April 2006
400mg Asacol 2x, 10mg Elavil, 75mg Effexor XR for GAD

"If you don't like something change it. If you can't change it, change your attitude"
Maya Angelou


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5191
   Posted 1/18/2009 8:58 PM (GMT -6)   
Generic Colazal has made some of us relapse-- so beware. Generics can have different inert ingredients than the original, among other considerations. / Old Hat (nearly 30 yrs with left-sided UC; original Colazal has been most helpful for me)

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16736
   Posted 1/18/2009 10:37 PM (GMT -6)   
That is exactly what I am worried about. It is not worth a relapse to me. This is the first time I have gone a week without a significant amount of blood in my poo and I am enjoying it! I don't think I could deal with all the symptoms I was dealing with a little over a month ago so soon turn
Old Hat said...
Generic Colazal has made some of us relapse-- so beware. Generics can have different inert ingredients than the original, among other considerations. / Old Hat (nearly 30 yrs with left-sided UC; original Colazal has been most helpful for me)

Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December but had symptoms months ago - Treating with Asacol (feel hopeless)


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5191
   Posted 1/19/2009 3:06 PM (GMT -6)   
According to my gastro, a new oral 5-ASA med, Apriso, is supposed to come on the U.S. market soon. From what I read about it so far on the I'net, it sounds like competition for Asacol because it is similarly designed to start dissolving in the patient's terminal ileum. This "competition" will hopefully lead to lower Asacol pricing. In my area the availability of a generic seems to have lowered the price of original Colazal ca. 20%-- not a sensational help to-date, but better than nothing. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

Shadam
Regular Member


Date Joined Jan 2009
Total Posts : 307
   Posted 1/19/2009 8:10 PM (GMT -6)   
I agree with Old Hat...i read an article about Apriso and it stated that the drug was approved by the FDA for UC and should be out on the market in Q1 of '09 (which is now)...apparently the drug is better then other 5ASA drugs because it disolves in your colon at a PH of 7 instead of 6....stay tuned i guess...
Age: 25 / Male / Florida
Diagnosed: 11/08
Currently on Asacol 2 x 3 day (waiting for results)
Prednisone / ended 1/09 (started at 30mgs and tapered down)
Started taking chamomile tea and multi vitamins (waiting for results)


tap
Regular Member


Date Joined May 2008
Total Posts : 474
   Posted 2/19/2009 7:31 AM (GMT -6)   
FrankGI stated "1. Generic drugs only have to be 80% the strength of its brand named counterpart. "

From the FDA's website (http://www.fda.gov/cder/ogd/#Introduction)

"A generic drug is identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use. Although generic drugs are chemically identical to their branded counterparts, they are typically sold at substantial discounts from the branded price. According to the Congressional Budget Office, generic drugs save consumers an estimated $8 to $10 billion a year at retail pharmacies. Even more billions are saved when hospitals use generics."
43 - male
Asacol - 3 400mg pills 3 times per day
Diagnosed with pancolitis about a decade ago


UCinGV
Regular Member


Date Joined Mar 2007
Total Posts : 403
   Posted 2/19/2009 8:23 AM (GMT -6)   
What's the price difference between Asacol and generic Asacol?
12 Asacol
100 mg Imuran


notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16736
   Posted 2/19/2009 9:31 AM (GMT -6)   

I am trying to get approved for the patient assistance program through Proctor and Gamble. I might not need to worry about taking generics afterall.

The price difference is not too substantial but it's worth considering if you pay out of pocket. On the Canadian Pharmacy I buy at, it is $69 for 100 Asacol and it's $66 for 120 generic. I've never ordered the generic because I am too worried it won't work and I'll have a massive flare.

That Apriso medication sounds pretty interesting.


Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December but had symptoms months ago - Treating with Asacol (feel hopeless)


UCinGV
Regular Member


Date Joined Mar 2007
Total Posts : 403
   Posted 2/19/2009 10:50 AM (GMT -6)   
tap said...
FrankGI stated "1. Generic drugs only have to be 80% the strength of its brand named counterpart. "

From the FDA's website (http://www.fda.gov/cder/ogd/#Introduction)

"A generic drug is identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use. Although generic drugs are chemically identical to their branded counterparts, they are typically sold at substantial discounts from the branded price. According to the Congressional Budget Office, generic drugs save consumers an estimated $8 to $10 billion a year at retail pharmacies. Even more billions are saved when hospitals use generics."


However, the FDA defines "bioequivalent" as follows. . .

http://www.fda.gov/cder/ob/docs/preface/ecpreface.htm

fda said...
The statistical methodology for analyzing these bioequivalence studies is called the two one-sided test procedure. Two situations are tested with this statistical methodology. The first of the two one-sided tests determines whether a generic product (test), when substituted for a brand-name product (reference) is significantly less bioavailable. The second of the two one-sided tests determines whether a brand-name product when substituted for a generic product is significantly less bioavailable. Based on the opinions of FDA medical experts, a difference of greater than 20% for each of the above tests was determined to be significant, and therefore, undesirable for all drug products. Numerically, this is expressed as a limit of test-product average/reference-product average of 80% for the first statistical test and a limit of reference-product average/test-product average of 80% for the second statistical test. By convention, all data is expressed as a ratio of the average response (AUC and Cmax) for test/reference, so the limit expressed in the second statistical test is 125% (reciprocal of 80%).

12 Asacol
100 mg Imuran


Peety
Veteran Member


Date Joined Mar 2008
Total Posts : 2855
   Posted 2/19/2009 12:28 PM (GMT -6)   
This has been very interesting reading today! Thanks to all who are sharing what they have learned.
Carry on...
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; started diet without gluten, soy, dairy, tomato etc. Probiotics (Ultimate Flora, 50 billion). Doing much better, but still having some bad days. 


Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 2/19/2009 12:30 PM (GMT -6)   
I posted a similar question, the current generic from Canada (actually from the UK) I received is called Mesren MR, I got one response from a man who used to take Mesren, here is what he said:


"Hi im from the uk and have been on both started on mesren mr and have now been on asacol for about 5 months i have not noticed differance think i was changed as dose doubled and asacol in larger dose pills so i dont have to take as many."
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, September 24, 2018 2:31 PM (GMT -6)
There are a total of 3,006,151 posts in 329,309 threads.
View Active Threads


Who's Online
This forum has 161825 registered members. Please welcome our newest member, TheRayf.
338 Guest(s), 17 Registered Member(s) are currently online.  Details
Michelejc, dbrookenz, BossJ, Grillmaster, Scaredy Cat, Admin, izziB, Lymie24, BillyBob@388, Serfr, dbwilco, InTheShop, Bubbatc, CAdogsRus, Mackster, Normal59, dsrouillard