Different kinds of mesalamine

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

pentasafan
New Member


Date Joined Jan 2009
Total Posts : 2
   Posted 1/21/2009 10:46 AM (GMT -6)   
Everyone may know this already, but my husband and I didn't so I thought I would share our experience...
My husband has UC and was dealing with it for 2 years. We went to a GI in our town and to the mayo clinic.  We tried Asacol, Asacol enimas, and prednisone. None of these worked so one Dr wanted to remove his colon and the mayo wanted to start him on immunosuppressant drugs.  We decided to get one more opinion.  This new doctor said that there are different types of mesalamine drugs that are made to release in different places in the colon. We had no idea and had done quite a bit of research.  My husband got on Pentasa and two weeks later was back to normal! We were so happy and I recommend trying the different types of mesalamine before going to more radical treatments.  It's been a year now and UC isn't even an issue.  As a side note though - when stressful things would happen, his stools would get a little loose so he's now on Lexipro for stress and that keeps the little flare ups from occuring.
(Also, keep a food journal to see which foods help and which ones hurt. I've noticed that it differs for all UC patients).

megger
Regular Member


Date Joined Oct 2008
Total Posts : 62
   Posted 1/21/2009 11:08 AM (GMT -6)   
I am curious to know where in the colon different mesalamine drugs are released? I am taking asacol right now and I don't feel like it is working the best... Where in the colon is Asacol released versus Pentasa??
Meghan
 
23 years old
Moderate-Severe Pancolitis
Diagnosed October 2008
12 Asacol (3 pills 4 times a day)
Entocort enemas nightly since Dec 2008
Daily Multi-Vitamins
Daily Fibre intake - 1 tbsp Metamucil
Protec Probiotics - I pill at bedtime


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 1/21/2009 12:20 PM (GMT -6)   
Asacol is designed to be release at the beginning of the colon and the med gets dispersed downward toward the rectum. However many people do not have the proper PH level in their colon to break down the hard outer coating of the Asacol and they don't get the right amount of medication to the correct area. Colazal is not a mesalamine but a basalazide. It is still a 5-ASA and it's release mechanism is a bit different. It releases it's medication lower down into the colon and is usually the more ideal med for people with left sided to proctitis. Lialda, the newest of mesalamines, is the same as Asacol - it just has a time released mechanism so less pills can be ingested. I can't speak about Pentasa because honestly I don't much about that medication.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-worked great!, OA in my fingers -Celebrex and Tylonel Arthritis
To help Healingwell - click here: DONATE
 
 
 
 

 
 


megger
Regular Member


Date Joined Oct 2008
Total Posts : 62
   Posted 1/21/2009 2:46 PM (GMT -6)   
I have pancolitis and am taking Asacol - so what I'm thinking is that maybe the meds are not making it down to my rectum if they are dispersed from the beginning of the colon downwards.... hmmm....
Meghan
 
23 years old
Moderate-Severe Pancolitis
Diagnosed October 2008
12 Asacol (3 pills 4 times a day)
Entocort enemas nightly since Dec 2008
Daily Multi-Vitamins
Daily Fibre intake - 1 tbsp Metamucil
Protec Probiotics - I pill at bedtime


livinlife
New Member


Date Joined Jan 2009
Total Posts : 10
   Posted 1/21/2009 3:36 PM (GMT -6)   
I've taken Salafolk (?sp) and I understand that it dissolves pretty far down in the intestine. Since changing to Asacol about a week ago I notice a huge difference. Thank God!! But I am not sure where it dissolves. I thought it dissolved near the same place as Pentasa...I'll have to do some research and I'll post what I find :)
Diagnosed with UC in 2006
Medications: Salofalk 2gms twice a day for maintance
Salofolk 4gms twice a day during flares
Betnesol retention enemas for flares - have been on back order so not available until Feb
Pentasa enemas and supps when first diagnosed
Asacol 2.5gms twice daily
Cortifoam enemas nightly for 3 weeks, then everyother night for 4 weeks
 


livinlife
New Member


Date Joined Jan 2009
Total Posts : 10
   Posted 1/21/2009 3:51 PM (GMT -6)   

I got this off a website. Hope it helps :)

 

How does Pentasa differ from Asacol
Both Pentasa and Asacol are prescription forms of mesalamine. The difference between Asacol and Pentasa is in the outer chemical coating. Oral Pentasa has a unique formulation. The active ingredient is contained in coated microgranules, which enables a prolonged release of the active substance throughout the intestinal tract, from duodenum to the rectum. Therefore the Pentasa preparation is more useful for Crohn's patients who often have inflammation of the small intestine. The average small bowel transit time is approximately 3-4 hours in healthy volunteers.

Asacol is a delayed release enteric-coated tablets which generally releases the active ingredient only in the colon. While there are always clinical exceptions, Asacol is generally suitable for patients with colitis only (ulcerative colitis or Crohn's colitis), but not disease involving the small intestine.


Diagnosed with UC in 2006
Medications: Salofalk 2gms twice a day for maintance
Salofolk 4gms twice a day during flares
Betnesol retention enemas for flares - have been on back order so not available until Feb
Pentasa enemas and supps when first diagnosed
Asacol 2.5gms twice daily
Cortifoam enemas nightly for 3 weeks, then everyother night for 4 weeks
 


megger
Regular Member


Date Joined Oct 2008
Total Posts : 62
   Posted 1/21/2009 7:14 PM (GMT -6)   
Thanks for the research!!! That helps alot! I almost think that because of the eneric coating on the Asacol that I may not be absorbing the drug properly.
Meghan
 
23 years old
Moderate-Severe Pancolitis
Diagnosed October 2008
12 Asacol (3 pills 4 times a day)
Entocort enemas nightly since Dec 2008
Daily Multi-Vitamins
Daily Fibre intake - 1 tbsp Metamucil
Protec Probiotics - I pill at bedtime


uran
New Member


Date Joined Jan 2009
Total Posts : 7
   Posted 1/22/2009 2:49 AM (GMT -6)   
I agree, Pentasa is a great 5-ASA drug! Too bad I can't take it anymore, 'cause it gives me severe stomach pain... But it did help with my proctosigmoiditis immensely :)
25 yr old female biology student, diagnosed with proctosigmoiditis in December 2008
Meds: Pentasa suppositories, 3x2 Pentasa, 75 mg Imuran, Salofalk enema, Xanax and Citalopram for anxiety
Supplements: Flaxseed oil capsules x 2, Vitamin U, Probiotics x 2

Post Edited (uran) : 1/22/2009 2:12:54 AM (GMT-7)


jblue65
Regular Member


Date Joined Jan 2008
Total Posts : 381
   Posted 1/22/2009 7:14 AM (GMT -6)   

HI all-

 I went from Asacol to LIalda to Colazal. I really think the Colazal has helped somewhat whereas the other two did not. Then again, I don't know since I take so many other things also.

I wonder how many people are really helped by these drugs, though. It seems that most of us take these and they are not effective ( we end up taking a ton of other things also)

 
Jackie, 43
Pancolitis, DX October 06

Lexapro, colazal 3x3, Synthroid, Protonix, 6MP (75 mg)
Prednisone 20mg, Iron, Vitamin D
Surgery almost certain


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 1/22/2009 7:52 AM (GMT -6)   
I see that people here often note that they cannot take mesalamine or that it causes side effects such as stomach pain and so on. I got that type of reaction to rectal mesalamine and I think the oral route, Pentasa, may also cause me stomach pain, D, and urinary retention and so on. Anybody else find these types of reactions from both types of mesalamine, I wonder?

23 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics. Latest issue is endless diarrhea without blood or mucous.
  • Psyllium powder
  • Culturelle probiotic
  • Pentasa
  • Cortenema


madabs
Regular Member


Date Joined May 2008
Total Posts : 388
   Posted 1/22/2009 8:14 AM (GMT -6)   
There is a new drug Apriso (sp?) that is mesalamine that breaks down in the colon at a ph >(or =) 6 which should help those whose ph levels were too low to get through Asacol's outer shell which requires ph >(or =)7(as red34 mentioned above).
UC diagnosed 10/05, first symptoms 1983
asacol 12/daily and rowasa as needed 
Trying out Culturelle Probiotic
past rx: colozal, lialda, canasa
i can't complain, but sometimes i still do.  lifes been good to me so far.  -joe walsh


megger
Regular Member


Date Joined Oct 2008
Total Posts : 62
   Posted 1/22/2009 9:23 AM (GMT -6)   

I found a site with more info on Apriso if anyone is interested...

http://www.rxlist.com/apriso-drug.htm


Meghan
 
23 years old
Moderate-Severe Pancolitis
Diagnosed October 2008
12 Asacol (3 pills 4 times a day)
Entocort enemas nightly since Dec 2008
Daily Multi-Vitamins
Daily Fibre intake - 1 tbsp Metamucil
Protec Probiotics - I pill at bedtime


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5182
   Posted 1/22/2009 9:01 PM (GMT -6)   
Colazal was my break-through 5-ASA in 2003 because I have left-sided UC, which the older oral meds like Azulfidine & Asacol only helped minimally. Dipentum, a drug of the mid-1990s, was a bit more helpful in controlling inflammation, but I still had D while on it. Recently I found out the hard way that the generic Colazal (Balsalazide) made by Watson Pharma does NOT control D, at least not for me. So I'm back on original Colazal, my ticket to remission. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

pentasafan
New Member


Date Joined Jan 2009
Total Posts : 2
   Posted 1/23/2009 11:21 AM (GMT -6)   
Wow, everyone is so knowledgeable, I love it! And Megan, my husband actually had some whole pentasa tablets in his stool which confirmed for him, that it wasn't releasing in the right place at all. 

Shadam
Regular Member


Date Joined Jan 2009
Total Posts : 307
   Posted 1/25/2009 9:08 AM (GMT -6)   
Hey all...I was diagnosed with Pancolitis in Nov...I started on Asacol (2 pills 3 x day). I didnt really see much difference in my syptoms. I then got on 30mg of Pred which did wonders...I'm assuming it greatly reduced my inflamation...i am still currently on Asacol and it seems to be working ok. I reguarlly have 1-2 bm's a day (some lose, some mushy...none formed). I have my 2nd colonoscopy in 3 months tomorrow...so hopefully I'll get some more answers..

Good luck to you!
Age: 25 / Male / Florida
Diagnosed: 11/08
Currently on Asacol 2 x 3 day (waiting for results)
Prednisone / ended 1/09 (started at 30mgs and tapered down)
Started taking chamomile tea and multi vitamins (waiting for results)

New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, June 25, 2018 9:47 AM (GMT -6)
There are a total of 2,975,005 posts in 326,234 threads.
View Active Threads


Who's Online
This forum has 161321 registered members. Please welcome our newest member, lowo1.
412 Guest(s), 9 Registered Member(s) are currently online.  Details
Jack@, GoBucks, JNF, LucyDog, Quay Labourer, Girlie, Tony T, Spanish, Zen Hen