As quincy says "run the course of everything you can before prednisone. That is what I have done. Found I can't tolerate mesalamine medications of any kind - although they helped a little. Used several enemas and the last one - hydrocortisone caused more bleeding each day and had to stop after 12. Had a scope and mine had advanced 4 inches up my colon from last test. Tomorrow is second day of 40 mg. of prednisone and probably later try 6MP if I respond.
Have you had a colonoscopy recently to be sure what you are dealing with right now. My doctor does not prescribe until he "looks". Good luck!
68 yr. old granny
New diagnosed with proctosigmoiditis - 6/2008
Colonoscopy 10/28 showed only few cm. left to heal in rectum - tried Proctofoam for weeks - no luck.
Probiotic Align, Prilosec for GERD
Inderol for hypertension,Xanax,Lipitor, multivitamin, calcium w/D, Tylenol
Tried hydrocortisone for two weeks with no change.
2/3/2009 - sigmoidoscopy showed about 30 cm. involved but mild - starting on prednisone only 40 mg. taper on 2/7/2009.