prednisone crash

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rowana
New Member


Date Joined Jan 2009
Total Posts : 13
   Posted 2/2/2009 5:29 PM (GMT -6)   
i have been on prednisone for over a year now for my UC, trying to taper down and am experiencing serious depression. i suffer from chronic depression, but had that under control, and now i am worse than ever! has anyone experienced this? i am seeing my therapist wed. and hopefully will get things worked out with my meds. perhaps i need to switch, but i was just wondering if anyone had any insite on this matter as it is very scarey. i just recently started 6mp in hopes that i will be able to come off this. thanks for any words of wisdom in advance.
R

Meesh
Veteran Member


Date Joined May 2006
Total Posts : 619
   Posted 2/2/2009 7:04 PM (GMT -6)   
I was on Prednisone for two years, and it just really does a number you, so I totally sympathize. My GI put me on Lexipro for the depression. While the difference it made was subtle, it was a huge help. I no longer found myself crying out of the blue. And while I wasn't suicidal, I wouldn't have been all that bothered if the proverbial bus had hit me. I was in a flare for much of two years, had bad reactions to many of the medications, and suffered a lot of side-effects from the Pred. Remicade made a big difference, but even then, it was over a year of infusions before I actually achieved a real remission, which I am enjoying now. Prior to the Remicade finally kicking in completely I had pretty much made up my mind to have the surgery, which I will probably do if I ever flare again -- I cannot go through another spell of what I experienced before remission.

You haven't posted what your medications are, but it can be really hard to nail down what combinations of medications and supplements will do the trick for you. If you haven't already tried an antidepressant talk to your doctor about it.

Meesh
46 yr old female, dx'd UC April 27, 2006; mild arthritis in lower back, dx'd May 2008; Osteopenia dx'd 6/08 Finally achieved remission mid October 2008!!

13 Remicade infusions: 1st: 7/21/07; most recent: 1/21/09; Current meds & supplements: Lialda, 4 tabs in the morning; Xanax as needed (rarely); Rowesa and/or Canasa; multivitamin w/folate; Culturelle; Fish oil capsules, calcium chews and/or Tums; Vitamin D;

Past meds: Prednisone 4/06-4/08; Entocourt EC; Asacol; Colazal; Venofer (iron) injections Dec '07; Imuran (extremely bad reaction 2/07); Protonix; Lexipro


ErinD
Regular Member


Date Joined Jul 2008
Total Posts : 94
   Posted 2/2/2009 7:18 PM (GMT -6)   
Rowana,
I have been on prednisone for a year and a half now and for the past few months the depression i have been going through is horrible. My husband has been a great support to me and we both know its due to the Prednisone but it is still so hard. My doctor is trying his hardest to get me off of it and has me on Imuran (we first tried 6-MP but i can't tolerate it). He is going to make sure it kicks in and then start tapering me in April. I am counting the days to get out of this funk.
First Diagnosed with Microscopic Colitis 10/07
Diagnosed with UC instead 3/2008
10mg Prednisone
50mg Imuran
75mg 6-MP
Calcium + Vit D
Probiotics
Entocort 9mg daily
800mg Asacol 3X daily
Bentyl
Lomotil
Dicyclomine
Prevacid
 


qazwsx12
Regular Member


Date Joined Nov 2008
Total Posts : 63
   Posted 2/2/2009 8:02 PM (GMT -6)   
I've been on it almost 5 months and feel like this is pushing it let alone a year or more. I'm almost off it but I feel like it's slowly getting worse again as the pred leaves my body. I'm hoping my doctor will agree to put me on Humira again so hopefully I can enjoy at least 3-4 months of remission. I will likely have surgery in the next year because these medications are unacceptable.

mythmoon
Regular Member


Date Joined Jan 2009
Total Posts : 135
   Posted 2/2/2009 10:51 PM (GMT -6)   
Pred does mess alot with your emotional stability. When I was on a higher dose I wasn't depressed but man did I have a short fuse. I would snap at everything. I also found myself have the strangest thoughts like what I did didn't have consequences at all. Kind of scary. Glad I'm almost off of it!
21 yr/old Uni student. Vancouver, BC
Imuran 150 mgs/day

Prednisone 10 mgs/day
Diagnosed UC Sept. 2007
Cal-Mag, CoQ10, L-glutamine and Iron supps. Also now trying probiotics Bio-K (acidophilus)


LoveAngels
New Member


Date Joined Jan 2009
Total Posts : 8
   Posted 2/2/2009 11:20 PM (GMT -6)   
Hi, I'm new here and haven't been online in a while due to being in a bad flare, but now I am doing much better. =)

I am currently on Prednisone, but only doing a short dose this time. I started at 40mg and I am tapering down each week. My GI and I are hoping that this will jump start my system without having to be on it for a long time. It's strange because even now I have become very emotional. I let things bother me way too much and end up crying. I did this recently at work when I found out there is a possiblity of being layed off - this also makes my stress go way up which is not good either.

I was previously on Pred. back in 2005 for about 1 year. I had a very bad flare. So I know what it's like to have some serious side effects. I had tons of shaking, increased appetite - weight gain, became depressed. I was so weak back then that I could not even get up very well without holding onto something and struggling. I am glad this flare is not like that at all!!

I sympathize with you rowana! Hang in there and I hope to hear soon that you get your meds straightened out, and things become better for you. Take care.
*Meredith
29 years old, female
Ulcerative Colitis -diagnosed in 2005.
Current Status: In a flare, but getting better.
Just taking it one day at a time.
Meds: Prednizone 40 mg-tapering down, Colazal, 6MP, and Remicade. I also take Iron and Folic Acid supplements.
 
 


rowana
New Member


Date Joined Jan 2009
Total Posts : 13
   Posted 2/3/2009 8:28 AM (GMT -6)   

thanks to all for responding. why don't the docs mention or even believe that prednisone can affect you this way? i have suffered depression for years and after a time of trying to deal w/ it the natural way, realized that anti-depressants really do help. i have to say, i felt my best on 10mg of prednisone, 20mg of cymbalta, and lialda, 2 pills 2xs a day. i stopped the lialda because i thought it was making things worse, spasms, liquid poo etc..is it possible that lialda could affect my mood? i know that the gi tract is a huge producer of seretonin, so maybe i'm messing that up w/o it.? i'm so confused! i have just started 6mp in hopes that i can get off the pred., but i hear it takes awhile for it to kick in.

Meesh~what type of surgery did you have?

wishing all good health and happy intestines!
R

mythmoon
Regular Member


Date Joined Jan 2009
Total Posts : 135
   Posted 2/3/2009 10:27 AM (GMT -6)   
This is why I always read the product info sheets that you can ask for at the pharmacy. Not all doctors think about stuff like the mood swings and how they affect people because the are so focuses on the bowel problem.
21 yr/old Uni student. Vancouver, BC
Imuran 150 mgs/day

Prednisone 7.5 mgs/day
Diagnosed UC Sept. 2007
Cal-Mag, CoQ10, L-glutamine and Iron supps. Also now trying probiotics Bio-K (acidophilus)


mtgman
Veteran Member


Date Joined Mar 2005
Total Posts : 1289
   Posted 2/3/2009 5:02 PM (GMT -6)   
I hate the stuff...back on it now after a short repreive...60 mg then taper...my wife thinks I get "roid rage" and turn into a real a-hole when i'm on the stuff. I have noticed that little things make me upset or cry...on one hand i love it becasue it instantly makes the bleeding etc. stop...but the rest of my body (mentally and physically) suffers a lot.

Meesh
Veteran Member


Date Joined May 2006
Total Posts : 619
   Posted 2/3/2009 5:11 PM (GMT -6)   
Rowa\ena, I didn't have the surgery -- last year I had pretty much resigned myself to the j-pouch surgery, did all the research and really got my mind wrapped around it, but then the Remicade finally kicked in good and my last colonoscopy showed my colon was just about healed, so I have put the surgery on the back-burner for now. I am self-employed and run a mobile dog grooming business by myself. If/when I have the surgery I will have to shut down while I recuperate and then hope my clients will still be there. There are several other mobile groomers in the area, and while my clients are very loyal, they do want need their dogs groomed and if I am unable they will go elsewhere. In this economy I wouldn't want to have to rebuild my business.

That said, I am not happy with all the medications I have to take for what could be the rest of my life. So right now I am saving as much money as I can to finance the two months I would not be working, and as soon as this downturn is behind us I may well go ahead and have the surgery, which is considered the cure for UC. At the moment I live in dread of losing our health insurance or if the benefits change for the worse as my meds are so expensive. My husband says he supports whatever I decide I need to do to feel well and at ease with my condition.

The one thing I worry about is if I do go ahead and have the surgery, which is permanent, then say a cure comes along that allows one to keep one's colon, such as stem cell research panning out and being able to provide a properly working immune system or UC-free colon. So I guess the longer i can remain in remission with medication the better.

But I will not go through another two year flare again -- if I start to flare and can't get it under control within a few months, out goes the colon!

Meesh
46 yr old female, dx'd UC April 27, 2006; mild arthritis in lower back, dx'd May 2008; Osteopenia dx'd 6/08 Finally achieved remission mid October 2008!!

13 Remicade infusions: 1st: 7/21/07; most recent: 1/21/09; Current meds & supplements: Lialda, 4 tabs in the morning; Xanax as needed (rarely); Rowesa and/or Canasa; multivitamin w/folate; Culturelle; Fish oil capsules, calcium chews and/or Tums; Vitamin D;

Past meds: Prednisone 4/06-4/08; Entocourt EC; Asacol; Colazal; Venofer (iron) injections Dec '07; Imuran (extremely bad reaction 2/07); Protonix; Lexipro


MustLoveDogs
Regular Member


Date Joined Jan 2009
Total Posts : 394
   Posted 2/3/2009 9:32 PM (GMT -6)   
My daughter was on 30 mgs and tapered off about 2 weeks ago. We are riding quite the emotional roller coaster in our house right now. She seemed to have the side effects AFTER she was off the Pred which I find really strange! The doctors like to hide the "scary" side effects of meds but I find the pharmacists to be much more helpful!

Boxermom2
Veteran Member


Date Joined Dec 2008
Total Posts : 601
   Posted 2/3/2009 10:18 PM (GMT -6)   

I have been on 40 mg of pred since Dec.  I started tapering to 25 and started flaring again.  Went back up to 35 and now and tapering to 25 again.  I can't believe it but today the urgency started again. 

I don't feel depressed on it though.  I just go crazy around the house.  I have painted the entire house, every cabinet is organized and I am very obsessive compulsive.  If I could get up at 3am and run the vacuum I would.  It's wierd and I can't wait to get off them.


mbx5
Regular Member


Date Joined Sep 2007
Total Posts : 365
   Posted 2/3/2009 11:11 PM (GMT -6)   
I have had a long love-hate relationship with pred being on it sometimes for 2 years. I have been through some roid rage issues that would draw a crowd. I have grown zits that could beat me in arm wrestling. I have punched walls and broken bones in the process. I have gotten moon face, mood swings, and appetites that brought me from 160lbs to 210lbs within months....I have been treated for depression for upwards of 6 years (no depression meds right now). Going through my twenties with UC, college, and roids....bad combination... BUT - I take the bad with the good. It works when I need it. Without pred, I would have had surgery by now.
34 yr old male. UC for 14 years. Started left-sided, most recent scope shows pancolitis. 30mg pred (as of 2/01/09), 12 pills Asacol per day, 1mg Atavan per day (anxiety) when needed, Super-omega fish oil pills - 1x per day, Flax oil pills - 1x am, 1x pm, Culturelle probiotics - 2x am, 1x pm, Spinach and sunflower seed diet. Multivitamin. Recent Endonasal brain surgery to remove non-cancerous hormone producing tumor on pituitary gland (and I am still more afraid of my UC!!) "I poop in the woods because I can"


iluvsunflowers15
Regular Member


Date Joined Apr 2006
Total Posts : 395
   Posted 2/4/2009 8:12 AM (GMT -6)   
Can being off prednisone for more than a year still cause some of these side effects? I feel I am depressed, have swinging moods, and a short fuse. Just curious. :)

Heather
Colazal 750 mg 3x3 daily
6-MP 50 mg (2) daily
Miralax-when needed
Rowasa-when needed
Been diagnosed with UC for 5 years

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