6MP and Side Effects

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Regular Member

Date Joined Dec 2008
Total Posts : 20
   Posted 2/4/2009 11:49 AM (GMT -6)   
just started 6MP yesterday and this morning I woke up with a mild headache, but it's getting worse. I checked the list of side effects and headache is listed. Has anyone else experienced headaches while on 6MP. Does Aspirin help?
Ulcerative Pan Colitis since March 2008
Balsalazide 3 750MGROX - 3 x per day
50mg 6MP      
Prednesone 2 occasions (hated it)
VLS#3 1 pack 3 x per day
Acidophalis - 4 tables per day

Regular Member

Date Joined Jan 2009
Total Posts : 394
   Posted 2/4/2009 11:54 AM (GMT -6)   
UC patients should not take asprin or Ibuprofen! Please talk with your Dr about alternatives or stick with Tylenol.
My 10 yr old has been on 6-MP for 2 weeks and she is very, very tired. She also has other symptoms that we don't know if they are from the 6-MP or something else.
10 yr old daughter diagnosed with "UC-like Crohn's" 12/08
currently on 2400 mg Asacol and 50 mg 6-MP

Regular Member

Date Joined Jul 2008
Total Posts : 94
   Posted 2/4/2009 12:05 PM (GMT -6)   
I was on 6-MP for 3 months and had horrible headaches while on it.   They did go away once I stopped taking it.  I did take Tylenol which helped some, but not all of the time.

First Diagnosed with Microscopic Colitis 10/07
Diagnosed with UC instead 3/2008
10mg Prednisone
50mg Imuran
75mg 6-MP
Calcium + Vit D
Entocort 9mg daily
800mg Asacol 3X daily

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 2/4/2009 12:10 PM (GMT -6)   
I've had nothing but headaches while being on 6mp. I've been on it for little over 2 years now. In the beginning they were pretty bad but now they are still there but much more mild. I found that regular Tylonel doesn't help me so I have been taking Tylonel arthritis which has a higher dose. Definately stay away from aspirin if you are an easy bleeder. Every once in while my headaches get pretty bad - migraine quality and I have to resort to Excederin Migraine. This has aspirin and caffeine in it. It makes me bleed but it gets rid of my migraine. I would much rather bleed then feel like my head is falling off!
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-worked great!, OA in my fingers -Celebrex and Tylonel Arthritis
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Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 2/4/2009 5:18 PM (GMT -6)   
     Never had headaches with the 6MP.  Do have thinning hair though.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

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