Going below 20mg/pred, any luck out there?

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Regular Member

Date Joined Aug 2008
Total Posts : 95
   Posted 2/9/2009 11:31 AM (GMT -6)   
Anyone have any tips? I went to 17.5mg last week, and did well until day #5 and then it started to look like a flare. Urgency came back. I have done 20mg this morning and everything is A-okay.
http://asilentocean.blogspot.com/  -> My blog
Diagnosed 7/27/08
Asacol- 2.4g/day
Prednisone 20mg/day 40mg/day  20mg/day and tapering again....

Regular Member

Date Joined Jan 2008
Total Posts : 381
   Posted 2/9/2009 12:11 PM (GMT -6)   
I can't go under 20mg either. Even at 20mg I am a mess, but at 15mg I cannot function at all. So for now, it's PRED for me

Jackie, 43
Pancolitis, DX October 06

Lexapro, Colazal 3x3, Synthroid, Protonix, 6MP (100 mg)
Severely Anemic
Prednisone 20mg, Iron, Vitamin D
Surgery almost certain

Regular Member

Date Joined Apr 2008
Total Posts : 460
   Posted 2/9/2009 12:51 PM (GMT -6)   
How do you take the pred (1x a day, 2x a day)? The reason I ask is because when I was on it, I found that if I split my dose into 3 or 4 times a day, I did much better. It just seemed like it stayed consistent in my body and I was able to wean and do well on it.
Female, Age 38
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03, Diagnosed with UC 2/03
Current Meds:
75mg 6-MP
Ferrex Forte
Acidophillus, Sacchromyces Boulardii, Oil of Oregano

Regular Member

Date Joined May 2007
Total Posts : 169
   Posted 2/9/2009 1:56 PM (GMT -6)   
Talk to your doctor about Imuran (or something else) if you haven't already. I also took an Adrenal Support supplement as I was coming off pred.
UC diagnosed Dec. 2006
Azathioprine 200mg/day
Multivitamin, fish oil, fiber supplement, Nature's Way Primadophilus Optima, Digestive Advantage Crohn's & Colitis

Cadillac Lover
Regular Member

Date Joined Feb 2009
Total Posts : 235
   Posted 2/9/2009 3:09 PM (GMT -6)   
i take the pred throughout the day, can you take a lot at once? i just lowered to 30mg a day this week but overall it's not working at all, I was on 40mg for the first 10 days and noticed very little change.
Diagnosed with UC summer of 08.
Currently taking asacol 1600mg 3 x a day, Prednisone for 50 days & Mesalamine rectal meds twice a day.
Currently having a flare.

Veteran Member

Date Joined Dec 2008
Total Posts : 510
   Posted 2/9/2009 3:27 PM (GMT -6)   
I have been tapering also... from 40 ( for months ) then we started to taper. I'm down to 15 mg. Everytime I drop a dose ( 2.5 gm at atime ) I get about 3 to 4 bad days... normally around day 4 to day 8 or 9 of the new dose. After that is gets back to normal. MY GI would like to taper me every ten days, but has found that it has to be every twenty. When he asks me at 10 days, I have to tell him things have been bad. Then after 10 more days I report things have been good and he drops it another 2.5 mg. He and I talked about this last time. Seems my body reacts badly to the drop, but levels out around day 10. He said it was not common, but not unheard of for this to happen. we just had to adjust my taper schedule to give my body time to adjust....
38 yr old male, NE Ohio, diagnosed Aug 2008, but been with symptom since Nov 2007
30 mg pred, 9 balsalazide, rowesa nightly, 2 gemfibrozil, 1 norvasc, 1 metoprotol, 1 allopurinol, 2 probiotic, 2 aloe vera tabs
Following gluten free diet as well as spinach/sunflower regime
**down to 25 mg of pred 12/25/08 **down to 20mg of pred 1/7/09**down to 17.5 mg 1/22/09
**down to 15 mg of pred 2/3/08
MED CHANGE: 1/13/09-- 4 Lialda, 2 Pamine Forte, 1 Florajen3 probiotic, 2 Aloe Vera tabs, Rowesa every other night, 20 mg of Pred, Lomotil as needed, 2 gemfibrozil, 1 norvasc, 1 metoprotol, 1 allopurinol

Veteran Member

Date Joined Dec 2008
Total Posts : 3231
   Posted 2/9/2009 4:45 PM (GMT -6)   
The bleeding would come back every time I went under 25 mgs. It's natural for the bleeding to come back when tapering off the medicine, because Prednisone stops the body's normal production of Cortisol. It takes awhile for the body to adjust and increase its production of Cortisol back to normal levels.

I'm not sure whether or not being on Prednisone after going down to the 25mg level really helps. In other words, will the flareup go away on its own whether or not we are on Prednisone? I think all the Prednisone does is reduce the bleeding until the inflammation goes away on its own.

I've had three flareups. All of them went away, not from Prednisone though. The first one went away by itself. The second one from fecal transplantation, and the third one from Probiotics and diet.
Joy - 47 yrs and counting
Diagnosed w/ UC Dec 06 (also have IBS)
Currently in remission

Lexapro (for stress)
Probiotics and Vitamins (a whole bunch of them)
Anti-inflammatory foods: turmeric, seaweed, garlic...
Avoid: anything with high-fructose corn syrup, foods high in fructose, artificial sweeteners
Previous treatments: Fecal transplantation (worked), Prednisone (stopped working), Colazal (stopped working), Asacol (stopped working)

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 2/9/2009 8:52 PM (GMT -6)   
Stay on 20 for another week and try to go down again. That's what I do, it's trial and error sometimes. I eventually can get down and off and out of a flare.

If you spread your dose out instead of taking it all at once in the morning, your side effects will be worse. But sometimes it's worth it if you feel real bad by the end of the day.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering.
Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; started diet without gluten, soy, dairy, tomato etc. Replete$$ probiotic powder, then Forte, now a stronger one (50 billion). Doing much better, but still having some bad days. 

Veteran Member

Date Joined Mar 2008
Total Posts : 1580
   Posted 2/9/2009 9:05 PM (GMT -6)   
Any long term pred users here WITHOUT side effects...details please : )
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3X per week and canasa every other day
Natural anti fungal, anti inflammation supplements and Probiotics.
Bowel Soother and IntestiNew, Fish Oil, Calcium, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Reduced sugar in my diet by at least 70%
Reduced wheat products by 70% 
Could never tolerate artificial sweetners
I excersice daily (unless like now : (  I've lost too much weight)
Did I happen to mention I HATE this disease!!!
*Recent Changes In Blue*

Regular Member

Date Joined Jan 2009
Total Posts : 135
   Posted 2/9/2009 10:55 PM (GMT -6)   
I'm down to 7.5mg and will be going down to 5 mg tomorrow ^_^ SO far so good. I am also on Imuran.
21 yr/old Uni student. Vancouver, BC
Imuran 150 mgs/day

Prednisone 7.5 mgs/day
Diagnosed UC Sept. 2007
Cal-Mag, CoQ10, L-glutamine and Iron supps. Also now trying probiotics Bio-K (acidophilus)

Regular Member

Date Joined Feb 2008
Total Posts : 214
   Posted 2/12/2009 11:59 PM (GMT -6)   
Sometimes on a prednisone wean you have to deal with increased symptoms, I would even have severe flare issues even while on higher doses, and that is without any dietary changes.  I am a big believer in stress causing many of my problems.  But after years of prednisone it caught up with me, and I know others that had severe side effects much earlier.  Keep trying and hopefully you can find that right level for your body, good luck
diagnosed 1998
now off prednisone and colazal
drink 1 Haldi daily to maintain remission 

Regular Member

Date Joined Jan 2009
Total Posts : 135
   Posted 2/13/2009 12:36 AM (GMT -6)   
well I'm down to 5 mg and no problems so far ^_^
21 yr/old Uni student. Vancouver, BC
Imuran 150 mgs/day

Prednisone 5 mgs/day
Diagnosed UC Sept. 2007
Cal-Mag, CoQ10, L-glutamine. Also now trying probiotics Bio-K (acidophilus)

Regular Member

Date Joined Jan 2006
Total Posts : 187
   Posted 2/13/2009 6:50 AM (GMT -6)   
I could not get below 20mg for years. I tried just about everything. On Jan 1 2008 I started Humira. Took a long time for it to really start helping. I was able to get down to 10mg of Pred but couldn't get any lower, even with the Humira.

about two months ago I decided to cut gluten out of my diet and am now down to 5mg without any problems. Cutting out gluten is having dramatic positive effects for me. I am still weaning of the pred but I am weaning very slowly. This it the first time in five years that I have been on this low of a dose of Pred and I'm doing the best I've ever done.

I am able to go on long drives again. I live in a small county town and one of my favorite things to do is to drive to Madison WI do things around town. It's about an hour drive and I can finally start doing that again.

Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 2/13/2009 9:30 AM (GMT -6)   
     Has your GI doctor suggested 6MP or Imuran?  Uncle Bubba...how long have you been on the prednisone?
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

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