UC and IBS maybe link.Which treatment should i try?

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Regular Member

Date Joined Jul 2006
Total Posts : 361
   Posted 2/12/2009 3:13 AM (GMT -6)   
According to this article IBS is link to UC.
I have IBS.Which treatment should i try?
How about Mesalazine rectal enema?
IBS and the Immune System:
Evidence continues to mount that IBS is “not all in your head”. A recent study published in the American Journal of Gastroenterology suggests that an immune system response may be responsible for IBS symptoms in some patients. According to the study’s abstract, biopsies of mucosal tissue were performed and the results analyzed for the presence of immune system cells. Comparisons were made among healthy controls, IBS patients, and patients who had microscopic or ulcerative colitis.

The results showed that compared to the healthy control subjects, IBS patients had a 72% increase in immune system cells. Half of the IBS patients had this increase. Compared to the patients who were diagnosed with either form of colitis, IBS patients had slightly lower immune system markers. Differences were seen in the types and amount of these immune system cells between male and female IBS patients. The amount of immune system cells was associated with symptoms of abdominal bloating and what the researchers call “dysmotility-like dyspepsia”.

This focus on immune system activity in IBS is a new avenue. The immediate benefit is the reassurance that you are not just “doing this to yourself” for some kind of crazy “attention” reason. The long-term benefit of studies like this one is that as IBS is better understood, the path toward better treatments become available.

-IBS induced by NSAID
-IBS-A,C with meteorism(trapped gas) and pubic burning-

Regular Member

Date Joined May 2008
Total Posts : 388
   Posted 2/12/2009 8:53 AM (GMT -6)   
It is my understanding that mesalamine is an anti-inflammatory so if the presense of immune cells causes inflammation then maybe it would work. Many years ago, when IBS was known as spastic colon, I believe I was given some sort of anti-inflammatory med as a small amount of inflammation was found in my rectal/sigmoid area. I have no idea what its name was. It didn't work, actually. My symtoms eventually became less acute over time.
UC diagnosed 10/05, first symptoms 1983
6mp * asacol 12/daily * rowasa pm * cortifoam am 
 Culturelle Probiotic - prilosec - metamucil capsules
past rx: colozal, lialda, canasa
i can't complain, but sometimes i still do.  lifes been good to me so far.  -joe walsh

Veteran Member

Date Joined Aug 2007
Total Posts : 2204
   Posted 2/12/2009 1:30 PM (GMT -6)   
That's interesting. My "gut" feeling has always been that IBS and IBD aren't totally separate conditions but are on a continuum of digestive disorders.
Diagnosed with ulcerative colitis spring 1999.
Maintenance dose sulfasalazine. Probiotics, l-glutamine, vitamin D and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal. Mostly grain-free and dairy-free diet. Long-term remission with only minor blips.

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