Fatigue and inflammatory disease connection (Research)

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pb4
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Date Joined Feb 2004
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   Posted 2/18/2009 1:11 AM (GMT -6)   

Disease linked to fatigue

Updated: Tue Feb. 17 2009 16:56:42

A research team at the University of Calgary believes they have discovered why diseases, like arthritis, make people so tired.

Dr. Mark Swain has found that inflammatory diseases like arthritis, inflammatory bowel disease and liver disease, allow so-called "immune" cells to infiltrate the brain and it's those cells that cause fatigue.

Dr. Swain says the fatigue can often be the worst part of a disease and that the next step is to reverse the process which in turn will stop the fatigue.

"I think when people have profound fatigue that's associated with inflammatory disease, they'll often say that it's the most incapacitating thing that they're experiencing from their disease and if they could only get over the fatigue, they could deal with the other aspects of their disease," says Dr. Mark Swain from the University of Calgary.

:)


My bum is broken....there's a big crack down the middle of it! LOL :)


quincy
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Date Joined May 2003
Total Posts : 30999
   Posted 2/18/2009 1:47 AM (GMT -6)   
Can you expand on how inflamed cells infiltrate the brain? any other info?

it's like a snowball effect, many with fatigue tend to get depression. hard to be motivated when it takes energy to function on a basic leve.

Good info, needing more to expand if you have it.
thanks for sharing

q
*Heather* Status..Asacol  (3 x2 daily); flaring /Dec 22, tapered to every 3rd nite..back to nightly (Jan 22)..tapered too fast
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


bookworm21
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Date Joined Mar 2008
Total Posts : 1766
   Posted 2/18/2009 8:53 AM (GMT -6)   
Not surprised at all. Fatigue is my worst symptom of UC. Even in remission I need at least 9 hours of sleep, I can't function without afternoon naps, and sometimes I can't even focus when I'm tired. I really miss my old body--I used to be able to survive on an hour of sleep if needed. Now I don't even want to try getting less than 8 hours of sleep!
 
My GI tells me it's just some of the depression and to exercise, but when I had depression before (and not UC) I still had more energy than this and I do get exercise almost everyday!
 
But the question is, how do we reverse this?


Female, Age 20 (formerly ComedyDork)
9 Asacol, Rowasa1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis)1 Florastor, 50 mg 6MP,1 Primadophilus reuteri, Remicade (6 infusions), 2.4 g Lialda, Forvia, 6 Colazal, 1 Anucort, Culturelle, Fish Oil, Calcium/Vit D supplement, 20 mg Prozac, VSL #3
 

Post Edited (bookworm21) : 2/18/2009 6:57:36 AM (GMT-7)


notsosicklygirl
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Date Joined Dec 2008
Total Posts : 16732
   Posted 2/18/2009 8:57 AM (GMT -6)   
Being fatigued is bad but running to the toilet every 5 minutes is equally as bad. tongue
Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December but had symptoms months ago - Treating with Asacol (feel hopeless)


madabs
Regular Member


Date Joined May 2008
Total Posts : 388
   Posted 2/18/2009 1:59 PM (GMT -6)   
That quote from the doc is spot on.
UC diagnosed 10/05, first symptoms 1983
6mp * asacol 12/daily * rowasa pm * cortifoam am 
 Culturelle Probiotic - prilosec - metamucil capsules
past rx: colozal, lialda, canasa
i can't complain, but sometimes i still do.  lifes been good to me so far.  -joe walsh


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 2/18/2009 2:15 PM (GMT -6)   
quincy said...
Can you expand on how inflamed cells infiltrate the brain? any other info?

it's like a snowball effect, many with fatigue tend to get depression. hard to be motivated when it takes energy to function on a basic leve.

Good info, needing more to expand if you have it.
thanks for sharing

q

No I can't expand, this is all that was written in the article.
 
:)
My bum is broken....there's a big crack down the middle of it! LOL :)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 2/18/2009 2:17 PM (GMT -6)   
I heard yrs back that when the body is fighting inflammation of any kind, especially for a long period of time, that fatigue was only natural to experiance, so this research doesn't surprise me at all.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Probiotic
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Date Joined Mar 2007
Total Posts : 2832
   Posted 2/18/2009 4:23 PM (GMT -6)   
I always figured fatigue when inflammation is present is the same as for any inflammation- e.g. if you have bad sunburn, or sprain your ankle or something... your body automatically conserves energy elsewhere to spend the energy on the inflammation (silly inflammation gone bonkers in the case of our IBD activity).. but this article suggests a brain connection too, which is new to me. Interesting. I wish I could drink coffee to fight my fatigue but it worsens my IBD.


Pancolitis >20 years, allergic to all 5ASAs
Tried everything under the sun (natural and alternative)
Some partial success with TSO but was too expensive to keep up 
Currently Remicade and lots of probiotics, tapering pred again, maybe surgery this year
 
 


subdued
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Date Joined Dec 2008
Total Posts : 3231
   Posted 2/18/2009 8:40 PM (GMT -6)   
I think anytime the body is working to heal itself, it will have less energy for other things. Being anemic doesn't help either.
Joy - 47 yrs and counting
Diagnosed w/ UC Dec 06 (also have IBS)
Currently in remission

Lexapro (for stress)
Probiotics and Vitamins (a whole bunch of them)
Anti-inflammatory foods: turmeric, seaweed, garlic...
Avoid: anything with high-fructose corn syrup, foods high in fructose, artificial sweeteners
Previous treatments: Fecal transplantation (worked), Prednisone (stopped working), Colazal (stopped working), Asacol (stopped working)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 2/18/2009 10:44 PM (GMT -6)   
Healing from severe inflammation like that of IBD and/or arthritis and such doesn't compare to just anything, like having an inflammed rash or gums or something so there is a difference. Not to mention, not everyone heals from their IBD let alone their arthritis, people with specific issues like that can have inflammation for yrs which is constantly got the body in "trying to heal mode" which is where the fatigue stems from. Anemia is different than inflammation.


My bum is broken....there's a big crack down the middle of it! LOL :)


doors12
Veteran Member


Date Joined Jul 2006
Total Posts : 726
   Posted 2/21/2009 1:26 AM (GMT -6)   
I expect to see more of this stuff coming out. Obviously something crossing the blood brain barrier.
Diagnosed with Ulcerative Colitis 6/2006 at age 26 after sudden E.R. visit
~Pancolitis (Mild to Moderate)
 ~I had Mono in 2000
On Colazal 3x3/day; Folic Acid 1mg; Calcium/Magnesium/Zinc combo
(Generic Balsalazide not as effective for me)
In remission about 2-3 months after E.R. but not back to normal!
I hate Ulcerative Colitis and can't wait till we eradicate it
 


sore_guts
Regular Member


Date Joined Jun 2007
Total Posts : 186
   Posted 2/21/2009 6:01 PM (GMT -6)   
I have to disagree with this drs quote about fatigue being one of the worst symptoms.  Personally, its much worse to be running for the bathroom a dozen times a day and have 5 seconds or less to make it, horrible pain, and blood loss.   I guess its good in some ways that they are researching why there is fatigue, but I'd much prefer if they would spend money and time on finding a cure instead.  I just feel like saying to this guy - duh, we're tired look at what we go through.  If you can fix that then we wont be so fatigued!
 sore_guts
 
Currently in Remission since June 2008!! Flaring again :(
 
High magnesium/ beta carotene diet
37 year old female with left-sided UC
lialda 1 pill  3 2 times/day
Digestive Advantage Colitis formula 1/day
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 2/21/2009 6:17 PM (GMT -6)   
The doctors quote is actually based on what patients have told him (it's not his personal opinion) and those were patients that have arthritis, so in turn it would make sense that arthritic patients could handle their arthritis better if their fatigue wasn't so bad.

And I give credit to these researchers for their time and effort researching fatigue and finding what they have found, it's obviously more than what other researchers around the world have cared to look into. Exactly how are they suppose to find a cure before the actual cause is found? Now that these canadian researchers have found a link they probably are on the road to finding a cure.


:)
My bum is broken....there's a big crack down the middle of it! LOL :)


mtgman
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Date Joined Mar 2005
Total Posts : 1289
   Posted 2/22/2009 10:49 PM (GMT -6)   
subdued said...
I think anytime the body is working to heal itself, it will have less energy for other things. Being anemic doesn't help either.

hi Subdued...there is a recent post regarding fecal transplant...i noticed in your sig that you had the procedure and it worked.  If you have some time can you check out the fecal transplant post and maybe add some words of wisdom?  It's someone else's post, but I've been gearing a lot and am interested to find out more.  Thanks!!

mollymcbutter
Regular Member


Date Joined Mar 2009
Total Posts : 130
   Posted 3/19/2009 12:58 PM (GMT -6)   
I say I'd have to agree with that, fatigue hasn't plagued me much but running to the bathroom so many times and so many times didn't make it that for me was the worst.  YOu know we need the doctors to guide us along to a point, but there is no way, even if you are a doctor, unless you have this disease what an actual day can be like...Molly
sore_guts said...
I have to disagree with this drs quote about fatigue being one of the worst symptoms.  Personally, its much worse to be running for the bathroom a dozen times a day and have 5 seconds or less to make it, horrible pain, and blood loss.   I guess its good in some ways that they are researching why there is fatigue, but I'd much prefer if they would spend money and time on finding a cure instead.  I just feel like saying to this guy - duh, we're tired look at what we go through.  If you can fix that then we wont be so fatigued!


mollymcbutter
Regular Member


Date Joined Mar 2009
Total Posts : 130
   Posted 3/19/2009 1:00 PM (GMT -6)   
That is for sure!!!!! turn
sicklygirl said...
Being fatigued is bad but running to the toilet every 5 minutes is equally as bad. tongue

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