I'm at the higher dose also- pretty much same scenario as you- it worked great for a while at the lower dose, every 8 weeks. Then just quit- so we upped it & shortened the dosing intervals to every 6 weeks. Worked good again! I have had to go every 6 weeks for about
8 months now, but am able to extend it to every 7 weeks. I have an infusion this Wednesday, & it'll be at 7 weeks, & I'm actually doing pretty well considering the longer dosing interval. I also see my GI this thursday, & I don't think we'll be making any med changes- things seem to be working pretty good for me right now, so I'm leery of changing anything. I don't think it's all that uncommon to be on the higher 10mgs/kg dose- quite a few people on here are at that dose, & also on a more frequent 6 week dosing schedule, both on the high dose & the standard one. Good luck! I think the big drawback is that most docs don't want to keep you at that dose for very long, maybe a year or so before they try to taper down.
diagnosed with UC '02
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07