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New Member

Date Joined Feb 2009
Total Posts : 16
   Posted 2/26/2009 4:41 PM (GMT -6)   
Does anyone know how long it takes for Asacol to start working? Only been on for 3 days. Also on Pred. was 40mg for a week now started to cut back on that to 35mg a day.
Working on bad flair due to stress.

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 2/26/2009 5:24 PM (GMT -6)   
I've been on Asacol since January 30 and Rowasa since February 6. I was in a horrible flare (diarrhea 15+ times a day). By February 6, the Asacol had started to make a small difference, but I noticed a big improvement when I started Rowasa...virtually overnight. Then I kind of stagnated for a week/week and a half. Then this the weekend I started improving again and have been steadily improving since.

So, I really can't say how long the Asacol took to start working. I think it depends on how bad your inflamation is and how well the Asacol works in your system. I think I read on their website that it can take up to three weeks. Just remember that the Asacol may be working in terms of reducing the inflamation, but that it may take a while for the inflamation to heal enough to also reduce your symptoms.

Have you asked your doctor about a rectal med? I really doubt I'd be doing as well as I am if I weren't using Rowasa.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).

Regular Member

Date Joined Jan 2009
Total Posts : 307
   Posted 2/26/2009 8:12 PM (GMT -6)   
I've been on Asacol since November of '08 and honestly dont see what it has done to me.  I also was on prednisone which I think did the trick.  I'm now only on Asacol but have started taking a lot of herbal stuff as well as changed my diet which I think are helping me a lot more. 

Age: 25 / Male / Florida
Diagnosed: 11/08 / Pancolitis
Asacol - 2 x 3 day (waiting for results)
Prednisone / ended 1/09 (started at 30mgs and tapered down)
Daily Green Tea, de-shelled sunflower seeds & spinach and 1 Multi Vitamin a day
Metamucil - 1 capsule a day

Forum Moderator

Date Joined Dec 2008
Total Posts : 16714
   Posted 2/26/2009 8:48 PM (GMT -6)   
It helped me within the first couple weeks. I remember being so thankful to have something that managed my symptoms.
Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December 08 but had symptoms months ago - Treating with Asacol 400mg (9 a day)

New Member

Date Joined Feb 2009
Total Posts : 16
   Posted 2/27/2009 5:07 PM (GMT -6)   
Thanks all.  I just started cutting down on Pred. only been a couple days on Asacol. See what happens.

Veteran Member

Date Joined Mar 2005
Total Posts : 1289
   Posted 2/27/2009 7:12 PM (GMT -6)   
i've been on asacol for years...i recently was pulled off due to elevated liver enzymes in connection with 6-MP...doc thought asacol contributed to raised levels...he was right...levels are dropping fast, but i definitly feel worse now that i'm off the asacol...

New Member

Date Joined Feb 2009
Total Posts : 16
   Posted 2/27/2009 7:21 PM (GMT -6)   
I am only on it 2 times a day so I hope that should help. Haven't had a flair up in 5-6 years. Have not been on any meds for that time either, but went back to smokiing and that helped me for years. Stress of losing a job was probably too much.

Veteran Member

Date Joined Dec 2008
Total Posts : 511
   Posted 2/27/2009 10:15 PM (GMT -6)   
I was on Asacol for almost two years. When I first started I noticed a difference almost immediately. However, I soon regressed back into a horrible flare so started 40mg Prednisone. Each time I tried tapering I became extremely ill (flare) by 25-30mg. So, I remained on Prednisone throughout all of our medication and treatment addition to the Asacol, which this past summer I was put on 2400mg twice a day.

To be honest with you, the Prednisone will probably make the biggest difference for you right now, and if you start to show signs of a flare and those symptoms continue or worsen I suggest you contact your doctor/nurse immediately. I learned that a flare can kick up within a matter of days, and normally I would put off a call b/c it was a Friday and the weekend was here, but by the following Monday I was miserable and a prisoner to our home (b/c of the needed bathroom).

Anyway, I so wish you the best of luck! Keep us posted on your reaction to the medications!
: )  Robin
28 year old Mommy of an amazing 1 year old and Wife for 2 years!
Dx-May 2007 Moderate/Severe Pancolitis - failed all medications
Proctocolectomy w/ permanent ileostomy on 02/06/09!!!
"Your mind is like a parachute, it only works when it is open."  -Unknown

Veteran Member

Date Joined Jul 2006
Total Posts : 2105
   Posted 2/27/2009 11:11 PM (GMT -6)   
I would ask for Apriso at this point. Seems to be a better delivery method as compared to the previose 5-asa's.
Proctitis DX 1999, Pancolitis DX 2008
Lialda 1 day
Golimumab study (100mg every 4 weeks)
Vitamin E Enemas as needed

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