The "should" be increased to nightly during a flare then once normal, start tapering to a maintenance dosage. (I've explained what I do in countless postings)
That's subjective, however. It's more of an ongoing process rather than nightly to twice weekly,
I've figured out my process through what I need...others have been able to taper off and then start when flaring then tapering off..etc.
The optimum maintenance dosage found through some studies is twice a week...I would equate that to every third or fourth night.
*Heather* Status..Asacol (3 x2 daily); flaring /Dec 22, tapered to every 3rd nite
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!