John and all of us, my son is a research scientist and I should ask him to try to come up with something that gives us only the GOOD side effects of prednisone. I am on 20 mg. now and see that the energy is leaving town! AND I enjoyed the help for my joints - the arthritis and my knees work so much better. No doubt that is why they call prednisone "the drug you love to hate".
As for sleeping - I take Xanax so I take 1/2 before bed and in the middle of the night if necessary so I sleep ok. I also have overactive bladder so up anyway a couple times.
There are definitely trade-offs for the good prednisone is doing. I have the slight moonface too although at 240 (yes, gained only 5 lbs. thank goodness but eating most of the time) and 5ft. my face is pretty round. I don't like it and hope it goes away.