Your Experience on 6mp?

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B00e00n00
Regular Member


Date Joined Mar 2009
Total Posts : 55
   Posted 3/19/2009 4:22 PM (GMT -6)   
Hi,

I am new here but have had Ulcerative Colitis since 2006, recently had a colonsocopy that revealed I had Left sided U. Colitis Never had symptoms go away though for the most part I've been able to avoid bleeding. Now I feel I'm starting to go down hill. I've tried limiting my diet (even went on juicing diet for 2 months). Doctor put me on Lialda 4 tab, a day but now I'm going down hill again after a week and a half. I've been on prednisone 9 different times for approx 1 week to 2 week periods but not since 2007 really. Symptoms always come back.

So I'm worried about 6mp, I know another Dr who I went to in 2007 wanted to put me on it. I've heard of some really bad effects from it. Anybody have some experiences they could share with me, is it safe enough, can they detect long term risks, not just short term? How successful was it for everyone. Let me know your condition so I can try and compare mine to it. Thanks and info is appreciated.

-Ben

betsaronie
Regular Member


Date Joined Oct 2007
Total Posts : 318
   Posted 3/19/2009 4:43 PM (GMT -6)   
6-mp put me in the hospital after an hour of ingesting it. Mine was a severe allergic reaction, it caused my pancreas to freak out. I'm part of a tiny percentage though. They do a blood test to test how your pancreas will react and only a few people with positive results still have a reaction - that would be me.
Its been great for a lot of others though. you honestly won't know how it affects you unless you try it. each case seems to be different.

btw, i have pancolitis and haven't obtained any remission since being diagnosed, just states of almost normal. the bleeding never goes away completely.
diagnosed with UC Dec 2006 at 22
diagnosed with IBS at 15
weekly accupuncture, probiotics, l-glutamine, and a combo of digestive enzymes. Staying gluten and dairy free as much as possible to avoid hard to digest proteins.
allergic or intolerant to all 5ASAs, sulfa and 6-mp


B00e00n00
Regular Member


Date Joined Mar 2009
Total Posts : 55
   Posted 3/19/2009 5:25 PM (GMT -6)   
I am so sorry to hear of that, that must of been miserable and is one the things I'm hoping to avoid, thankfully its rare but that comes with no solace to you, sorry. I hope things clear up for you soon.

P.S. not to get off topic but I see you've tried Probiotics, do those help any?

happydays
Regular Member


Date Joined Sep 2007
Total Posts : 69
   Posted 3/20/2009 11:16 PM (GMT -6)   
I've been on 6mp for a year & haven't had any big problems just really tired & i get sick alot!!! But Probiotics r great!!! Good Luck!!!
Mild case of UC~04   Left Side Colitis~ 05-06  Pancolitis~ 07
 
6-mp 125mg ~ Lialda ~ 4 pills a day ~ Librax 5-2.5mg~3 times a day ~ Lexapro 20mg ~ 1 a day ~ Zegerid ~ 1 a day ~ Birthcontrol ~ 1 a day ~ Humira (started 3-13) ~ canasa at night
 
     Only been in Remission Once, Praying Humira works!!!
 


WishfulMA
Regular Member


Date Joined Jul 2008
Total Posts : 197
   Posted 3/21/2009 7:40 PM (GMT -6)   
I am now on 100mgs of 6MP. I started the drug January 20th. I hear it takes at least 3 months to work. I have no side effects EXCEPT loss of appetite.
I had to go back on prednisone and increase my 6MP because I was still flaring. Right now I am on 20mgs of pred. I guess the real answer will come after I am off the prednisone. Good luck.
severe ulcerative proctitis - march 05 diagnosed
proctosigmoiditis - january 09 diagnosed
hospitalized - 3/08 for 6 days of IV steriods
hospitalized - 1/09 for 5 days of IV steriods / put on 6MP
past meds: colozol, sulfasalzine, hydrocortisone enemas, canasa, rowasa and prednisone 
current meds: 6MP (75mgs), Asacol 12 pills,  Rowasa Enema, Primal Defense Ultra Probiotic, fish oil, calcium w/ vitamin d 2x a day, prenatal vitamin & extra vitamin c and b12.
 
 


kops2da
Veteran Member


Date Joined Jun 2008
Total Posts : 2865
   Posted 3/22/2009 8:38 AM (GMT -6)   

Hi!  At what point did you have to increase your 6MP and prednisone.  I started on 40MG prednisone, tapering to 30 after a week and now on 20 for third week.  A week into 20mg. doctor put me on 50MG 6-MP (now three weeks)- about when the bleeding that had stopped returned.  It is only in mucuous with my formed stool.  I also started on Anusol as most of my discomfort/UC is proctitis.  I am supposed to taper to 15mg. prednisone next week but I think I better call and find out since I still see blood.  NO other symptoms of UC really - almost normal otherwise. I do have "soreness" where I sit!  BOY - I would love to lose my appetite (for a while) as I have gained a few lbs. and I am already WAY overweight. 

ElaineNY

WishfulMA said...
I am now on 100mgs of 6MP. I started the drug January 20th. I hear it takes at least 3 months to work. I have no side effects EXCEPT loss of appetite.
I had to go back on prednisone and increase my 6MP because I was still flaring. Right now I am on 20mgs of pred. I guess the real answer will come after I am off the prednisone. Good luck.


 
Senior - New diagnosed with proctosigmoiditis - 6/2008  Cannot tolerate mesalamines, Canasa, etc. Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred.
Started on prednisone Feb.7, 2009 - tapering to 20 mg. for two more weeks and then down to 15 mg.etc.  Added 6-MP Feb. 28.
Added Anusol suppositories - March 16 - see doc in 3 months. 
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.
 
 
 


Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5965
   Posted 3/22/2009 12:42 PM (GMT -6)   
     I've been on 6MP for over five years now.  It really hasn't kept me out of flares.  I still get a flare once a year.  Last May when admitted to the hospital my pancreatic enzyme levels were extremely high and my GI doctor took me off the 6MP.  However, six days later (still in hospital), my enzyme levels had returned to normal...so, I have no idea whether it was caused by the 6MP, a lab boo boo or what.  Put me bck on the 6MP last summer because I just couldn't get into remission.  I was on prednisone for seven months.  The 6MP finally kicked in after about three months and I was tapered off the pred.  Nov 1st was my last dose of prednisone.  The only side effect I have from the 6MP is thinning of my hair.  I told my GI doctor on Wednesday about it and his answer..."well, would you rather be suffering with the UC or have thin hair."  I can always plop on a wig..lol.
     My doctor keeps close tabs on my enzyme levels and liver function tests and so far, so good.  My white count is kinda low...2.9 this month, but everything else is A-OK.  My rectum has felt a little funky this last week and I started the Cort enemas every other night.  I've had this disease for over ten years and know when things aren't just right.
     One more thing I would like to add.  I saw a GI surgeon after being discharged from the hospital, but still flaring.  His opinion was that the 6MP is helping me even if I do have yearly flares.  My UC is confined to my rectum and his thought were that the 6MP is keeping the UC from traveling further into the colon.  He also put my mind at ease because I was concerned about lymphoma.  He mentioned that in all his years of practice (and it has to be over 30 yrs), he had only come across one patient who developed Lymphoma while on 6MP and who is to say that patient wouldn't develop Lymphoma had he not been on 6MP?  Hope this puts your mind at ease somewhat.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

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