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Regular Member

Date Joined Mar 2009
Total Posts : 63
   Posted 3/26/2009 10:16 PM (GMT -6)   
I'm on 5-ASA meds at the moment, I have read that after a few months the medication stops working and I am honestly upset... is it guaranteed that they will become ineffective?

Veteran Member

Date Joined Dec 2006
Total Posts : 517
   Posted 3/26/2009 10:25 PM (GMT -6)   
Not a guarantee. Every person is different and reacts differently. Some folks have been able to maintain remission taking the same dosage of the same drug for years, while others seem to run through drugs faster than they are being invented. Its the same with any medication...there is a chance your body will develop a tolerance and the drug will become less effective.

Try to look at the bright side, which is the relief you'll get from the drug while it is working. No need to dwell on the "what ifs" of the situation.

36 y.o. male
Diagnosed w/ UC in May '06, had symptoms since '99
Meds & supplements: LDN 3.0mg, Florastor, Lialda, Allegra, multi-vitamin, buproprion, fluoxetine, vit E, D, zinc, and pancreatic enzymes.

Elite Member

Date Joined May 2003
Total Posts : 30999
   Posted 3/27/2009 12:31 AM (GMT -6)   
I've been on 5ASA meds..oral/rectal for over 20 years....still effective.

Some don't want to use the meds, are on too many initially then stop because of side effects, some aren't on rectal meds as well...basically rendering the oral meds half useful (and perceived to not be working)..etc

Yes, for some they aren't enough...but for some, even the big gun meds aren't enough and surgery is necessary. 
5ASA meds are also strongly believed to protect the colon from cancer....that's a huge plus for me.


*Heather* Status..Asacol  (3 x2 daily); Salofalk enemas nightly for flares, tapered to maintenance  mild flare nightly enemas
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Post Edited (quincy) : 3/27/2009 9:50:52 AM (GMT-6)

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 3/27/2009 7:51 AM (GMT -6)   
I was on Asacol for 12 years before it stopped working for me (I'm on Colazal now and it works but I need 6mp too). So no, it doesn't necessarily mean that it will stop working for you after a while or not at all. It all depends on how your body is going to respond to it.

Q explained it very well. There is no guarantee written in stone when it comes to UC.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
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Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 3/27/2009 10:22 AM (GMT -6)   
Really, with any disease, there are no guarantees as to what medicine will work and what medicine won't. It's frustrating, yes, but just something that we have to deal with, unfortunately. And I've decided that I'm lucky that at least there is a CURE for this disease. Yes, having surgery to remove one's colon is a drastic step, but at least I know that if it comes down to it, I can be rid of this disease.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, 40mg 30mg 20mg of Prednisone (quick taper), Culturelle probiotic, and Zoloft (25 mg).

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 3/27/2009 6:26 PM (GMT -6)   
My scopes show that where the Asacol reaches is more healed, has scar tissue but less, than further along. Hence, the need to hit both ends! More than 20 years including the study period, I would frankly be afraid to try to risk going without it. It never has stopped occasional flares, though.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering. Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; eliminated all wheat/gluten from my diet. Probiotics (Ultimate Flora, 50 billion), trying Curamin. 
Flaring, seasonal? or supplements too harsh? Back on prednisone, tried to taper but now back up to 20-30 after several really bad days. Waiting for insurance decison on Humira...soon... 

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