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Regular Member

Date Joined Dec 2008
Total Posts : 199
   Posted 3/29/2009 4:10 AM (GMT -6)   
I have heard that the amount of melatonin can effect many things in the body, including UC? Has anyone tried any melatonin supplements or adjusted their sleep-wake cycles in a way to match a more natural circadian rhythm? Maybe that's part of why my colitis has been so bad lately, with the change of seasons and my horrible sleep cycle.
Asacol-12 a day
1 Culturelle
1 Canasa
2 Fish oil supplements
1 Vitamin

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 3/29/2009 6:50 AM (GMT -6)   
I am a horrible chronic insomniac and I tried Melatonin many many years ago. It never helped me with my sleep cycle nor my Uc but I did find that if I don't get the proper amount of rest my Uc tends to act up a bit.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
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Veteran Member

Date Joined Dec 2007
Total Posts : 536
   Posted 3/29/2009 8:30 AM (GMT -6)   
I take melatonin, which has no effect on my UC, but does help my sleep and overall wellbeing, I guess.

23 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics. Latest issue is endless diarrhea without blood or mucous.


Regular Member

Date Joined Apr 2007
Total Posts : 459
   Posted 3/29/2009 10:04 AM (GMT -6)   
I have used melatonin and I have noticed that it's only effectice if taken in large doses at a time.
At least 24mg per night must be taken and it mus be the slow release form, anything less and you are wasrting your time

New Member

Date Joined Mar 2009
Total Posts : 6
   Posted 3/30/2009 4:51 PM (GMT -6)   
The GNC melatonin that is sublingual has worked very well for my husband with UC. It has helped him with the sleep interruptions the pred. seems to cause.
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