To pb4: Another thought on The Origin of UC

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WorrywartNana
Regular Member


Date Joined Dec 2008
Total Posts : 86
   Posted 3/31/2009 12:10 PM (GMT -6)   
To pb4:
 
You have had UC a long time.  You are very knowledgable in current prescribed and alternative treatments for UC.   I am sincerely interested in your opinion of the the following info I took from a website while I was researching UC.
 
Cause of Crohn's & UC:
In healthy people, the iron that's in food, is transported from your intestines into your blood.  Iron is needed for creating hemoglobin (red blood cells).
 
For some unknown reason, the transport mechanism, that should transfer iron into your blood, is defect in persons with Crohns & UC.
 
The body's natural responce to an inflammation/infection is decreasing the iron transport from the intestines into the blood. This is done because bacteria needs iron for growth.
 
However when the inflammation is INSIDE the intestines, this defence mechanism works contra productive.   This causes the following situation :  Defective Iron transport causes iron build-up in the intestines.   
 
Iron is a catalyzer in The Haber-Weiss reaction (google this to see what that means).
 
Simply said : A big amount of iron in your intestines creates a very big amount of hydroxyl free radicals!  Free Radicals can do substantial damage to your intestine cells.
 
As a result, your defence system initiates an attack on itself - it attacks the intestine cells.   An inflammation is the result!
 
So...    free Radicals destroy intestines cells!
 
Even worse, the bone marrow, which is responsible for creating hemoglobin, doesn't receive iron anymore.  Without the iron, it can't create red blood cells and thus the person gets anemia as a bonus!
 
The bone marrow sends a message to the intestines: "Please dissolve more iron and transport it to me!"
 
The intestines starts creating large amounts of soluble iron.  However, it can't be transported to the bone marrow because of the defective transport mechanism, as stated earlier.
 
Results: This is a vicious cycle that  you won't be able to break!
 
The iron in the intestines causes a second problem.
 
Because of the excess of iron in the intestines, the bacteria in the mucus of the intestines will thrive. It will completely destroy the natural balance of bacteria in the intestines. The bacteria start producing acids and the intestines cells have no protection for that.    So, the amount of digestive enzymes also decreases rapidly.
 
pb4:  Do you think the above is a good description of the cause of UC?
 
And, do you know if "lemon water" or "garlic oil macerate"  would at least help to stop this cycle from happening?
 
My apology for such a lengthy post.  Sorry, there was no way of shortening it without losing the content.
 
Ideas, anyone?
 
***thanks moderator,  for the info re putting website addresses in posts.  I'll know better next time  turn   
 
 
G'son - diagnosed moderate to severe UC 12/2008 - 1st Prednisone 40mg (now finished); on Asacol 800 x 6; Didrocal 90 dys; reaction to Asacol 800, currently not on any meds;  multivitamins; probiotics; boost; flaxseed; Tylenol & gravol for pain & nausea. 

Post Edited (WorrywartNana) : 3/31/2009 12:37:02 PM (GMT-6)


pb4
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Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 12:39 PM (GMT -6)   
The vitamins C and E, are thought to protect the body against the destructive effects of free radicals. Antioxidants neutralize free radicals by donating one of their own electrons, ending the electron-"stealing" reaction. The antioxidant nutrients themselves don't become free radicals by donating an electron because they are stable in either form They act as scavengers, helping to prevent cell and tissue damage that could lead to cellular damage and disease. Eating plenty of fruits and veggies (ones that you can tolerate of course) are also beneficial in aiding with free radicals...the excess of iron leading to bacterial overgrowth (something IBDers tend to have issues with) is the main reason why I take probiotics daily and indefinitely. I don't know if lemon water or garlic oil macerate would stop the cycle from happening but they may aid the problem along with a good probioitc and the other above mentioned.
 
I also don't know if the above description would be the actual cause of UC, I see IBD according to the way many top lead researchers see it, as basically it being a genetic disorder that also has to have a trigger for it to become a disease.  However that's not to say that the excess iron couldn't be a trigger, but I still believe one must first be predisposed (genetics) in order to get an IBD, just as many researchers believe.

I appreiciate the fact that you value my opinion, and I hope that I've been able to help some with your question, but I should clear up that I actually have had crohn's colitis (CD affecting the colon) for a very very long time, too long LOL!


:)


My bum is broken....there's a big crack down the middle of it! LOL :)

Post Edited (pb4) : 3/31/2009 12:42:16 PM (GMT-6)


WorrywartNana
Regular Member


Date Joined Dec 2008
Total Posts : 86
   Posted 3/31/2009 1:15 PM (GMT -6)   
Thanks pb4 and yes, I do value your opinion.  As a 40 year veteran of a "chronic illness" myself (not IBD related) I find "experience" sometimes speaks for itself!  
 
 I am interested in anything that will help to ease my 19 yr old g'sons UC driven life!  
 
I agree with you wholeheartedly...   there has to be a "trigger" to the disease.   Pehaps if we knew the "reason" why UC patients have a defect transport mechanism (for transferring  iron into the blood) in the first place, we would know what the  cause is?  If a number of individuals in one particular family have UC, I would have to agree that there could be two different approaches:  environmental (including their lifestyle) or genetics. 
 
It's interesting to note that UC is more prevailent in the US, Canada & Europe than in Asia.  I wonder if that is because of "diet" (rice, fish, soya). 
 
Researching "diets" for UC I have found most of them suggest you stay away from "onions" (garlic?) and citric juices (lemon?) yet when you look at the medicinal values of organic garlic and lemons, they appear to have many components UC patients really need.   I guess what works for some doesn't necessarily work for all.
 
 
G'son - diagnosed moderate to severe UC 12/2008 - 1st Prednisone 40mg (now finished); on Asacol 800 x 6; Didrocal 90 dys; reaction to Asacol 800, currently not on any meds;  multivitamins; probiotics; boost; flaxseed; Tylenol & gravol for pain & nausea. 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 1:47 PM (GMT -6)   
True, what works for some doesn't work for all, makes it more frustrating for us and for researchers too I'm sure. I notice in your tag line your son no longer uses flaxseed or probiotics, was just curious why? By not taking them does he feel any worse/different, as in did he find they didn't help any at all? Sometimes it's just a matter of trying different probiotics before you find the right one that works because as we all know what works for some doesn't work for all, same with fibre supplementation.

The thing about familial IBD is that because researchers aren't sure exactly how IBD is passed down, it can skip many generations so I still think that somewhere along the bloodlines it's genetics and then it's also a matter of it being triggered since I'm 100% sure that there are/were many people who are/were predisposed to getting an IBD but they may have gone their entire lives being "healthy" because it wasn't triggered for them...in my family, so far only myself and my mom have an IBD, she has UC, but she didn't get it until her mid 60's had she died before she had hers triggered then I would be sitting here telling everyone that I'm the only one in my family that has ever had it, which would be wrong because since my mom is still living and hers was triggered, even at a late age, that proves that many are likely predisposed to getting it and that it being triggered is the other half of the puzzle. All my other siblings are older than me but as far as I'm concerned anyone of them could be predisoposed to getting it and if not then that doesn't leave their children out of the woods either, even if my siblings don't get it doesn't mean their kids or grandkids won't.

And true that it's less prevalent in some other parts of the world, they are starting to see an uprise in areas where it was virtually non-exsistant which is odd but definitely shows that environmental factors are strongly at play, especially when you consider in some parts of the world they have jumped onto the fast-food frenzy as well, granted I'm sure a big mac in china isn't quite the same as one in north america but additives are still additives, another reason why I avoid fast-foods and processed foods/beverages.

I hope they find the answers soon so we can all be put out of this misery....any chronic illness is devistating so I'm hoping the stem cell therapy will be the answer to all chronic illnesses.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


burnabygirl
Regular Member


Date Joined Jun 2008
Total Posts : 205
   Posted 3/31/2009 2:08 PM (GMT -6)   
WorrywartNana said...

It's interesting to note that UC is more prevailent in the US, Canada & Europe than in Asia. I wonder if that is because of "diet" (rice, fish, soya).


Is it because Asians usually drink boiled water? Or, Is it because they don't eat so much frozen meat? In Asian countries, people tend to go to the markets to buy fresh meat for meals everyday.
Ulcerative proctitis diagnosed in July 2006. Medications: Salofalk enema nightly.
Remission from Nov 2006 to Oct 2007. Then a bad cold and a bad flare for 1 year till Nov 2008.
Pancolitis diagnosed in April 2008. Current medications: Salofalk enema, Salofalk tablets 1000mg x 3/day, Entocort enema (tapering).
Supplements: Calcium with Vitamin D, Vitamin B Complex, Vitamin C and psyllium capsules (Metamucil).


WorrywartNana
Regular Member


Date Joined Dec 2008
Total Posts : 86
   Posted 3/31/2009 3:00 PM (GMT -6)   
I'v just editted my profile:
 
My grandson is back on Didrocal, vits, boost, flaxseed and probiotics but still is not taking any prescription drugs.  His Specialist says it takes 4 weeks to get the Asacol out of his system.  The allergic reaction has settled down quite abit but he still has bloody diahrrea and an upset stomach.  However, the severe acne, mouth ulcers, headaches, and joint pains have stopped, thank goodness!  He was such a mess! 
 
I think he was too sick to really notice if there was any difference being off the probiotics and flaxseed.   His doctor wanted him to stop "everything" as she wasnt sure which he was reacting to.  It's now confirmed it was the Asacol.
 
Flaxseed powder is very easy to use...  I sprinkle it in my spagetti sauce, add it to my meat loaf.  And probiotic yogert is such a nutritional snack!  Everyone in our family eats it!
 
I guess I am looking at every and any available way of dealing with UC, especially non-prescription drugs, after the reaction he had to Asacol.  All of these drugs have such horrific side effects, it's scarey!
 
With over 40 years of chronic illness,  I have built up an allergy and/or immunity to penicillin, sulfur drugs, antibiotics,  pain killers, and anesthetics.  These drugs destroyed my overall health.  For the past 10 years I have dealt with my medical problems WITHOUT "drugs" (prescription or over-the-counter!).    
 
I am hoping my grandson will eventually be able to do the same even though his disease is different than mine.
 
I relate familial IBD to Cancer in my family.  And I raise the same questions: 
 
Why were my daughter and grandson AND six other people in our small Canadian community, all diagnosed with UC or Crohn's disease around the same time (within one month of each other)?  Was it water or food born bacteria (Listeria & e-coli were both in our area at the time.   And, we all ate some of the meat products that were later "recalled" due to possible "listeria" bacteria)?   Was it community environment, contageous? transmitted by money?  ....  genetics?
 
Why did my Mom, Dad and "both" of their dogs get Cancer (all four died withing 6 months of each other)? Could it be the home environment, contageous, water or food born bacteria - was it genetics?   They were not on a city domestic waterline - they had their own water well.  They owned a fruit orchard - was it chemical insecticides?
 
You can see why I question the cause of UC. and seek answers.   My search is taking me far and wide.  It's a challenge and very intreging.   Every opinion helps further me along.
 
G'son - diagnosed moderate to severe UC 12/2008 - 1st Prednisone 40mg (now finished); on Asacol 800 x 6; Didrocal 90 dys; reaction to Asacol 800, currently not on any prescription meds;  is now back taking multivitamins; probiotics; boost; flaxseed. 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 3:30 PM (GMT -6)   
Wow worrywartnana, those are some coincidences aren't they, explains your member name (worrywart) I would be too with all that's gone on in your family...where in Canada are you? I'm in Alberta, the hotspot for IBD, especially crohn's, it's the hotspot for asthma too though (another immune disease).

If you're interested in knowing the natural anti-inflammatories that I use to help treat my crohn's, it's bee propolis (shouldn't be used if there is an allergy to bees though), omegas 3-6-9, vitamins A, C-Calcium Ascorbate, B12 (which doesn't treat my symptoms of IBD but does treat the nerve damage I was starting to get as a result of not being able to absorb B12 via foods alone), probiotic called primadophilus reuteri made by natures way, and fibre supplements (one called Prodiem stool bulking therapy), the bee propolis made a tremendous difference and quickly too, cutting out all my lower back pain and bleeding, and cutting back my frequency qite a bit, I was going 30+ times/day before taking the bee propolis, even my GI was thrilled with my success and told me to continue with it indefintiely since it is 100% non-toxic. It's now been about 5 yrs and I've been taking one 500mg cap 2 times/day.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


WorrywartNana
Regular Member


Date Joined Dec 2008
Total Posts : 86
   Posted 3/31/2009 4:27 PM (GMT -6)   

I'm in northern BC still buried in 3 ft of snow!  How can disease of any kind live in such isolated, frozen regions!  Is there UC in the extreme hot climates of the world?

Thank heaps,  for listing all the suppliments you're taking and I'm glad to hear they're working.  I've made note of all of them and will "google" them for more info.

My grandson is taking probiotics yogert with BL Regularis in it.  I'll "google" compare that with the one you are taking.  

Thanks pb4.

 

 

 


 
Grandson - diagnosed moderate to severe UC 12/2008 - 1st Prednisone 40mg (now finished); on Asacol 800 x 6; Didrocal 90 dys; reaction to Asacol 800, currently not on any prescription meds;  is now back taking Didrocal, multivitamins; probiotics; boost; flaxseed. 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 4:38 PM (GMT -6)   
LOL, yes there actually is IBD in the warmer/hot climates too...love BC (you guys have had a crappy winter this yr for sure), have a sister and a brother that live in Naniamo, brother just got DX with throat cancer (he hasn't smoked in over 25 yrs) so we're suppose to be planning a trip up to see him this summer, not looking forward to the travelling from here to there, and the ferry ride especially doesn't sit well with me.

Good idea to google the info on the supplements I posted, saves me from writing, keep in mind what works for some doesn't work for all but it's always nice to get ideas of things to try cuz you just never know where to start sometimes.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


WorrywartNana
Regular Member


Date Joined Dec 2008
Total Posts : 86
   Posted 3/31/2009 7:18 PM (GMT -6)   

Burnabygirl: 

I didn't know that Asians used mostly boiled water.  Thanks!  My list of demographic differences relating to UC get longer and longer. 

Sorry to see you spent the past year flaring!  That's aweful!  Here I am, worrying about my grandson flaring for 4 weeks!

I see in your profile that you use Metamucil.   Just recently I bought a Pink Lemonade flavoured Metacmucil...  haven't tried it yet but I plan to.   

My grandson decided to use the flaxseed powder because it also contains some Omega 3 and is less likely to cause constipation.  He just sprinkles it on his cereal in the morning.   I also use it in my meat and caserole dishes.  

 


 

 


 
Grandson - diagnosed moderate to severe UC 12/2008 - 1st Prednisone 40mg (now finished); on Asacol 800 x 6; Didrocal 90 dys; reaction to Asacol 800, currently not on any prescription meds;  is now back taking Didrocal, multivitamins; probiotics; boost; flaxseed. 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 8:16 PM (GMT -6)   
Just be careful with that type of fibre supplement, that's why I take the caps, no extra/un-necessary additives, fillers, sugar in them.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Mackster
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Date Joined May 2007
Total Posts : 768
   Posted 3/31/2009 9:01 PM (GMT -6)   
Very interesting post. What is actually meant by 'lemon water'? Is it what I think it is, ie a glass of water with a few drops of lemon juice in it?

bookworm21
Veteran Member


Date Joined Mar 2008
Total Posts : 1766
   Posted 3/31/2009 9:34 PM (GMT -6)   
I second the question about lemon water. I love water with a few drops of lemon in it!
 
Not all Asians boil water; and if they do, it's because they don't have purifying systems (whether local or personal) like we do. When I go to India, I always boil water or drink bottled water because my body isn't used to uncleaned water; but most Indians are able to drink water without boiling it. This could provide some support for the "hygiene hypothesis," which says that 3rd world countries don't have diseases like IBD because their bodies are able to adjust to the germs in the environment, whereas we live in a too purified enviornment.
Female, Age 20
9 Asacol, Rowasa1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis)1 Florastor, 50 mg 6MP,1 Primadophilus reuteri, Remicade (7 infusions), 2.4 g Lialda, Forvia, 6 Colazal, 1 Anucort, Culturelle, Fish Oil, Calcium/Vit D supplement, 20 mg Prozac, VSL #3 DS, Turmeric
 


burnabygirl
Regular Member


Date Joined Jun 2008
Total Posts : 205
   Posted 3/31/2009 9:40 PM (GMT -6)   
WorrywartNana,
I have lived in Hong Kong and I know people in most Asian countries use boiled water, except for the Japanese. I think it's because of the hot climate resulting in more bacteria in the water. One more thing: Asians don't eat as much uncooked vegetables as Caucasians do and they don't add so many ice to their drinks.
My recent flare was terrible. I was sent to ER twice for dehydration due to diarrhea. My husband asked the doctor there if I was going to die.
I take 1 Metamucil capsule 3 times a day. It bulks up my stool and I don't have diarrhea anymore. Having said, I am still not 100%. Urgency and bloody mucous are still bothering me. I am still taking oral and rectal medications.
BTW, I'm also in BC, Burnaby to be exact.
I wish you grandson will feel better soon.
Ulcerative proctitis diagnosed in July 2006. Medications: Salofalk enema nightly.
Remission from Nov 2006 to Oct 2007. Then a bad cold and a bad flare for 1 year till Nov 2008.
Pancolitis diagnosed in April 2008. Current medications: Salofalk enema, Salofalk tablets 1000mg x 3/day, Entocort enema (tapering).
Supplements: Calcium with Vitamin D, Vitamin B Complex, Vitamin C and psyllium capsules (Metamucil).


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 3/31/2009 9:41 PM (GMT -6)   
yes, water with fresh lemon juice in it, just be sure to brush your teeth well because lemons love to attack the enamel on teeth.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30591
   Posted 4/1/2009 2:19 AM (GMT -6)   
Just don't brush immediately after drinking lemon water or any fruit juice or eating fruit.....it will soften the enamel and brushing will cause more erosion. Wait at least a half hour after... (as per an article I saw on tv warning parents about enamel erosion and fruit juice.

q
*Heather* Status..Asacol  (3 x2 daily); Salofalk enemas nightly for flares, tapered to maintenance  mild flare nightly enemas
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


mudua
Regular Member


Date Joined Apr 2007
Total Posts : 459
   Posted 4/1/2009 12:21 PM (GMT -6)   
WorrywartNana said...
Thanks pb4 and yes, I do value your opinion.  As a 40 year veteran of a "chronic illness" myself (not IBD related) I find "experience" sometimes speaks for itself!  
 
 I am interested in anything that will help to ease my 19 yr old g'sons UC driven life!  
 
I agree with you wholeheartedly...   there has to be a "trigger" to the disease.   Pehaps if we knew the "reason" why UC patients have a defect transport mechanism (for transferring  iron into the blood) in the first place, we would know what the  cause is?  If a number of individuals in one particular family have UC, I would have to agree that there could be two different approaches:  environmental (including their lifestyle) or genetics. 
 
It's interesting to note that UC is more prevailent in the US, Canada & Europe than in Asia.  I wonder if that is because of "diet" (rice, fish, soya). 
 
Researching "diets" for UC I have found most of them suggest you stay away from "onions" (garlic?) and citric juices (lemon?) yet when you look at the medicinal values of organic garlic and lemons, they appear to have many components UC patients really need.   I guess what works for some doesn't necessarily work for all.
 

 
"It's interesting to note that UC is more prevailent in the US, Canada & Europe than in Asia.  I wonder if that is because of "diet" (rice, fish, soya). "
 
My Doctor is from India says that India has the highest number of IBD cases in the world.
 
 
 

Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 4/1/2009 12:33 PM (GMT -6)   
What do they eat in India?

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 4/1/2009 12:34 PM (GMT -6)   
My understanding is the highest rates of IBD are in north america and other developed countries.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


robray
Regular Member


Date Joined Mar 2005
Total Posts : 130
   Posted 4/1/2009 3:56 PM (GMT -6)   
I find the origins of IBD very strange.

I went to an IBD seminar last night in Vancouver, where I live, and the doc said he has seen studies correlating IBD to the refridgerator and even the TV. It seems to correlate with everything.

I also read that UC was more prevalent in northern climates. I was thinking vitamin D might play a part in that, but then that doesn't explain why India would have such a high occurance. Personally, I seem to get sick in Feb or March after a few months of dreary, grey, crap weather.

One thing i heard about India is that it is common to go to the doc with a cold and leave with a prescription for antibiotics. I don't know how true that is, but I believe antibiotics are the root cause of my disease. Maybe places that haven't adopted the western medical practices of precsribing antibiotics like candy are the ones that have fewer incidences of IBD.
UC (Pancolitis) diagnosed in 1992.
   Medications: Dipentum, Salofalk Enemas, prednisone (Stopped 2008), entocort enemas (Stopped 2008), Cortenema (Stopped), Asacol (Stopped 2003)
   Other therapies: Spinach & Sunflower Seeds, gluten free, dairy free (except for aged cheese and SCD yogurt), rice free, HPI (2008), SCD (Stopped, but still make yogurt), Vitamine E enema
Osteoporosis diagnosed in 2008.
   Medications: None yet, but they want me to take fosamax
GERD diagnosed 2008, but had it forever.
   Medicaitons: Parriet (Stopped)


Rio in Maryland
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Date Joined Nov 2007
Total Posts : 891
   Posted 4/1/2009 4:16 PM (GMT -6)   
In recent times, IBD has increased significantly in places like India. General consensus there is that this is because of increased consumption of processed foods, higher stress levels - diets and lifestyles have become increasingly 'Westernized', even in smaller towns.

I've been to India several times in the past couple of years and even got looked at by two GI specialists there. Though they offer similar medicines to the UK and USA, they are more willing to recommend alternative treatments, supplements, and lifestyle changes as they don't practice with the fear of litigation (from recommending non-FDA approved treatments).
Rio, 33 year old male. Diagnosed with UC in 2006
100 mg Azathioprine, 4800 mg Asacol
VSL#3 x 3 times a day, Metamucil wafers
Vitamin E enema or Mesacol/Asacol enema at least once a week
Spinach & sunflower seed diet


Malkavian
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Date Joined Mar 2009
Total Posts : 1439
   Posted 4/1/2009 5:22 PM (GMT -6)   
Being trained in biology with a decent background in biochemistry, I'm going to call bullcrap on this one. If it were true, everyone with UC/ Crohn's disease would be anemic, which clearly isn't the case. In addition, it doesn't explain the elevated levels of C-Reactive proteins found in the blood of people with IBD. Plus, we know that at least for Crohn's and most likely for UC, the immune system is involved. Thus far the most plausible thing I've heard is the hygiene hypothesis. The idea is that disorders of the immune system occur because we've evolved for millenia to coexist with invaders and to fight them off. If we're too 'clean', we aren't exposed these invaders and our immune systems become confused and start attacking things that they shouldn't. In the case of IBD, a lack of parasites causes the confused immune system to attack the gut wall. This explains the elevated levels of autoimmune disorders in developed countries as compared to third world countries.
21, female, diagnosed 3/6/2009
Currently taking Asacol (3x/day) and Prednisone (tapering dose)


Malkavian
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Date Joined Mar 2009
Total Posts : 1439
   Posted 4/1/2009 5:22 PM (GMT -6)   
Being trained in biology with a decent background in biochemistry, I'm going to call bullcrap on this one. If it were true, everyone with UC/ Crohn's disease would be anemic, which clearly isn't the case. In addition, it doesn't explain the elevated levels of C-Reactive proteins found in the blood of people with IBD. Plus, we know that at least for Crohn's and most likely for UC, the immune system is involved. Thus far the most plausible thing I've heard is the hygiene hypothesis. The idea is that disorders of the immune system occur because we've evolved for millenia to coexist with invaders and to fight them off. If we're too 'clean', we aren't exposed these invaders and our immune systems become confused and start attacking things that they shouldn't. In the case of IBD, a lack of parasites causes the confused immune system to attack the gut wall. This explains the elevated levels of autoimmune disorders in developed countries as compared to third world countries.
21, female, diagnosed 3/6/2009
Currently taking Asacol (3x/day) and Prednisone (tapering dose)


Sara14
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Date Joined Mar 2007
Total Posts : 4192
   Posted 4/1/2009 6:17 PM (GMT -6)   
Interesting thread.

Just wanted to add that I've never been anemic, so I know that is not the cause of UC, at least not for everyone. I also know it's not from antibiotic overuse for everyone, since I had barely ever taken antibiotics before getting UC.
25 years old; diagnosed March 2007;
Currently: persistant rectal inflammation
Asacol, 4 tabs, 3xday; Rowasa nightly; Viactiv; Metamucil wafers; multivitamin; Primadophilus Reuteri; sublingual allergy drops; Ortho Tri-Cyclen


bookworm21
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Date Joined Mar 2008
Total Posts : 1766
   Posted 4/1/2009 6:48 PM (GMT -6)   
I highly doubt that India is the leading country in terms of IBD. I talked to an Indian GI, who said I probably wouldn't have gotten this disease if I was living in India due to being exposed to all types of germs (hygiene hypthoesis). But it is believable that the number of IBD cases are growing in India due to the westernization of urban areas.
 
It's hard to say what people in India it since it depends on which area they live in. Some are vegetarians, some eat meat. There are a lot of fried Indian foods, which is definitely not good (health-wise). I would say that the common thread would rice and some sort of carb/bread product (like naan); the rest would depend on the person. 
 
I've heard about the northern climate and vitamin D connections as well. I think there needs to be more research on that; there are many claims that say vitamin D improves this symptom, that disease, etc. I have low vitamin D levels right now, but I'm in remission.
 
I also agree that UC is not caused by anemia or antibiotics for everyone. During my first flare, I was very anemic; but during my second flare, my hemoglobin stayed in normal range. And I haven't used antibiotics since early elementary school.


Female, Age 20
9 Asacol, Rowasa1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis)1 Florastor, 50 mg 6MP,1 Primadophilus reuteri, Remicade (7 infusions), 2.4 g Lialda, Forvia, 6 Colazal, 1 Anucort, Culturelle, Fish Oil, Calcium/Vit D supplement, 20 mg Prozac, VSL #3 DS, Turmeric
 

Post Edited (bookworm21) : 4/1/2009 6:53:15 PM (GMT-6)

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