Anyone on sulfazine/azulfidine? I have some questions....

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ilmare
New Member


Date Joined Mar 2009
Total Posts : 2
   Posted 3/31/2009 7:54 PM (GMT -6)   
My UC is pretty well managed on even very low dosages of Asacol. Was on just 800mg a day for a full year with no problems before a recent mild flare up.The problem for me is the severe joint pains. The joint inflammation likes to torture me and move up and down from the hips, entire back, and neck area. At times, it was so severe that I couldn't walk or turn my neck.
 
My GI wants me to go on sulfazine since it is also used to treat rhumatoid arthritis. Just started it today. Of the side-effects, I know that orange skin, urine and sweat is completely harmless and nothing to worry about, but I'm a girl and I can't help but be a worried about it. I would hate to look like those those people with fake orange tans. I also wear a lot of white and almost all my bedding from towels, sheets, comforters, blankets, etc. - all white. (Yes, its obessesive, I know...) I'd hate to see them be stained...
 
For those on sulfazine, how bad was the staining? Is there a correlation b/w dosage and color?
 
Also, headaches and sun sensitivity are a concern for me. I live in L.A., doing things outdoors and enjoing the sun is big part of living here. In addition, I'm graduating from law school this year and with the prospect of studying for the bar, I really can't afford to be distracted by headaches while I study.  
 
Any input from someone who has experienced of these side-effects and how to deal with it would be very much appreciated. Thanks in advance!
 
 
Currently tampering off prednisone after a flare-up - 10mg a day
Started 1000mg Sulfazine 4 times a day.  

Old Hat
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Date Joined Feb 2007
Total Posts : 5190
   Posted 3/31/2009 8:32 PM (GMT -6)   
I took Azulfidine en-tabs at low dose many yrs back. It made me thirsty & photosensitive, but my skin tone never changed; I either covered up or used a strong sunscreening lotion. Have you discussed your joint pain with a rheumatologist? Just wondering if a rheumy could give you better advice on medication for the joints than the gastro. Be aware that while on sulfasalazine you need to take a folic acid supplement daily because sulfa interferes with absorption of that nutrient. / Old Hat (30 yrs with left-sided UC ... [etc.])

ilmare
New Member


Date Joined Mar 2009
Total Posts : 2
   Posted 3/31/2009 9:29 PM (GMT -6)   
Thanks for the tip on folic acid!

My GI wanted me to try sulfazine first. Kill two birds with one stone. If I end up not being able to tolerate the side effects, then go back to asacol and to a Rheumatologist for additional treatment. I want to be on as little medication as possible and this sounded like a good idea. However, I do want to be prepared for the side-effects and understand how bad it could potentially get...

Dr-A
Veteran Member


Date Joined Jul 2006
Total Posts : 2105
   Posted 4/1/2009 5:52 AM (GMT -6)   
It never affected my color like that.
Proctitis DX 1999, Pancolitis DX 2008
Lialda 1 day
Immuran
Golimumab study (100mg every 4 weeks)
Vitamin E Enemas as needed
Probiotis/GreenTea/VitD+Ca/SuperDHA


White Beard
Forum Moderator


Date Joined Feb 2009
Total Posts : 3702
   Posted 4/1/2009 8:35 AM (GMT -6)   
ilmare I have been on sulfasalazine since 1990 when I was first diagnosed with UC, the last number of years I take one 500 mg tablet at 6AM and 6PM I have never had a problem with changing the color of my skin or sweat or any thing except it does make my urine a deep golden color, and if you dribble it can stain but is washable! At higher doses  8 tablets  4Gm  q12h I was having problems with ringing in my ears and some photo-sensitivity problems. I was only on that dosage  for a very short time when I had my first flare and then I was also on 90mg of prednisone a day.  Even now just as a precaution I always use a really good sunscreen when I go outside for any length of time. Which is a good practice reguardless if you are on meds or not! When I do have a flare they just up my sulfasalazine and put me back on prednisone and it usually takes care of it.  Only a couple of times have I ever had  to go the enema route to stop a flare up!
Good Luck to You
 
White Beard


 

I'm Retired USAF, went back to school and became an RN, and now am on ful disalbility!

Degenerative Disc (affecting mostly the thorasic disc but all levels involved), C6/7 laminectomy/diskectomy& fusion, Osteoarthritis, Ulcerative colitis, Chronic Pain, Fibromyalgia, Complex Sleep Apnea, and host of other things to spice up my life!(NOT!)

Medications: Oxycontin, Percocet, Baclofen, Sulfasalazine, Metoprolol, Folic Acid, Supplemental O2 at 3lpm with VPAP Adapt SV

Post Edited (White Beard) : 4/1/2009 7:39:30 AM (GMT-6)


IndianaUC
Regular Member


Date Joined Feb 2007
Total Posts : 212
   Posted 4/1/2009 8:45 AM (GMT -6)   
I take 4 500mg tablets in the morning and 4 500mg tablets at night. I've been on them for a year now. I worried about it's side effects too, but after being trapped in the house for months I decided to try my luck and lay out and get a tan. I tanned perfectly with no orange hue. I have off white sheets with stripes and there has never been any orange stains on my sheets. However my urine is bright/dark orange and seems to be...a bit thick at times?

I think it's all the extra "sediment" in the pills. That's why they warn about orange staining. Your body will work extra hard to get out what it doesn't need however it can. My goes through my kidneys but someone else's body might try to get it out through the skin.

When I first went on them I had massive headaches. I got through that and I am now fine. It took about a week to get used to the new pills tho. I don't have headaches anymore.
- DXed with "left sided" UC in 1998. DXed with "proctitis" Oct. 2007
- Sulfasalazine 3 500mg tabs twice daily
- 500mg Vitamin C, 1 Multivitamin, L-Glutamine
- Max Acidophillis EC Capsules 350Mg(7 types of bacteria with over 42 billion viable cells) with 50 Mg colostrum & 50 Mg FOS(fructo-oligosaccharides)
- Experimenting with this or that on occasion. Always open to new ideas.
- Colonoscopies - 2 (Due for my next one ASAP)
- Canasa 1000mg @night. Started Oct. 23, 2008
- Niferex-150 Forte 1 capsule 2x Daily


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 4/1/2009 9:17 AM (GMT -6)   
I've been on it for years at a maintenance dose and occasionally on a therapeutic dose when I have a mild flaring up of symptoms. I've never had any problems, but I am cautious - as anyone should be - about sun exposure and use sunscreen and/or cover up if I'm going to be exposed more than an hour or so.

I'd second the suggestion on the folic acid and drink plenty of fluids.
Diagnosed with ulcerative colitis spring 1999.
 
Maintenance dose sulfasalazine. Probiotics, l-glutamine, vitamin D and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal. Mostly grain-free and dairy-free diet. Long-term remission with only minor blips.
 
 


rdm
Regular Member


Date Joined Apr 2006
Total Posts : 229
   Posted 4/1/2009 11:05 AM (GMT -6)   
As with others no skin coloration issues, pee is colored. Headaches at first, got through that and really no problems with the drug for over 20 years. Definitely makes me more sensitive to the sun but I cover up and or use sun screen. Take the folic, as it reduces the bodies ability to absorb that vitamin. It is a really cheap, well tested and relatively benign drug.

princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 4/1/2009 1:42 PM (GMT -6)   
Not to mention some feel the sulfa component of the drug is as beneficial, if not more so, than the ASA component. It worked much better for me than asacol.
Diagnosed with ulcerative colitis spring 1999.
 
Maintenance dose sulfasalazine. Probiotics, l-glutamine, vitamin D and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal. Mostly grain-free and dairy-free diet. Long-term remission with only minor blips.
 
 

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