I don't see any rectal meds in your signature...is there a reason that you haven't tried them in conjunction with the Asacol?
What symptoms were you having from the Asacol?
I'd consider to start from square one...Asacol and a rectal med (I'd suggest Rowasa if you're in the US..Salofalk or Pentasa if you're not). If you find that 5ASA meds are for sure not working for you, you could consider a steroid enema/foam enema.
Then there are always suppositories.
Do get on a probiotic and a fibre supplement, however.
It's tough being in another flare....but you could try to stay off pred and see if the 5ASA can work for you.....it does take time.
*Heather* Status..Asacol (3 x2 daily); Salofalk enemas nightly for flares, tapered to maintenance mild flare nightly enemas
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!