Why are only colons affected with UC?

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Got2Believe
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Date Joined Feb 2007
Total Posts : 436
   Posted 4/3/2009 10:16 AM (GMT -6)   
Does anyone know why our colitis doesn't spread to the small intestine? Is there a reason? Are there several reasons? Which is the best reason? Is it still a mystery like so many other UC "phenomenons" Is it because different organs have totally different genetic material and composition or is it b/c of the environment inside the walls?

AnnaG
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Date Joined Apr 2008
Total Posts : 191
   Posted 4/3/2009 11:26 AM (GMT -6)   
I suppose, that is one of the ways they differentiate between crohns colits,and ulcerative colitis

Red_34
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Date Joined Apr 2004
Total Posts : 23551
   Posted 4/3/2009 11:48 AM (GMT -6)   
Why do eye infections remain in the eye? Why do any infection stay where it is? It's the same for UC. It's the nature of the beast. It could have something to do with the genetic component of UC too. Researchers have discovered a defective gene in people with Uc, so maybe this gene controls the extent of inflammation and damage. If I am not mistaken, don't quote me here, this defective gene is similiar in both Uc and Cd except that there are some differences in between the two. I know I've read this somewhere but I can't remember where - it's been a while.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
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fruitgirl
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Date Joined Feb 2009
Total Posts : 7150
   Posted 4/3/2009 12:42 PM (GMT -6)   
And then thinking about other autoimmune diseases...why does RA attack the joints, and UC and CD attack the GI tract? Our bodies are so very complex...at least with the genetic research that can be done now we can start to understand the cause.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, 40mg 30mg 20mg 15mg of Prednisone (quick taper), Culturelle probiotic, and Zoloft (25 mg).


pb4
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Date Joined Feb 2004
Total Posts : 20577
   Posted 4/3/2009 12:56 PM (GMT -6)   
Like Sherry said, it's the nature of the beast, it's what makes it different from crohn's and it very likely does have to do with the genes because there are specific genes that are related to crohn's and not UC, they are both crappy diseases, with similar symptoms including the same extra intestinal manifestations that are involved, like arthritis, osteo, eye, skin issues.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Got2Believe
Regular Member


Date Joined Feb 2007
Total Posts : 436
   Posted 4/3/2009 2:43 PM (GMT -6)   
Sherry you asked an equally interesting question. Why don't eye infections spread? What causes an "infection?" I'm not a Dr but i would think a bacteria, virus, fungus or other contaminate? Could that be a reason why it doesn't spread. The contaminate favors the environment that it initially attached onto and thrives there? I have a huge inclination to believe my UC was caused by offsetting the balance of my microflora and/or intoducing something bad that liked living in my colon so thats where my mindset is.

Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 4/3/2009 3:00 PM (GMT -6)   
I really have no clue on the why's of UC. No one can pinpoint the exact cause and there can be so many factors contributed to UC that I have a hard time wrapping my mind around all the possibilities.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
To help Healingwell - click here: DONATE
 
 
 
 

 
 


Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5975
   Posted 4/3/2009 3:04 PM (GMT -6)   
     Isn't that why they call it colitis?  Because it affects the colon? shocked
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 4/3/2009 3:16 PM (GMT -6)   
yes Christine, col=colon, itis=inflammation, anything with itis on the end of it means inflammation.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)

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