Anyone ever have severe muscle pain and insomnia with Prednisone

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Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/5/2009 1:43 AM (GMT -6)   
I've taken Pred in the past for 2 months for UC and a week or so once or twice for sinus infections.
Last time I had a sinus infection they gave me avelox and UC. I had SEVERE muscle pains and insomina -- ended up in the ER.
ER doc said it was a common serious side effect of Avelox so ever since I've been labeled with an Avelox allergy.

A week ago I started on Pred again for UC and the last few nights I have not been able to sleep at all and I'm having severe
muscle pain -- just like when I had the Avelox problem. Now I'm wondering if it was never the Avelox and was always the Prednisone.
I do not see muscle pain listed as a side effect for Prednisone though, but if it is the Pred, which I NEED for the UC, what the heck
are they going to do for me!

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 4/5/2009 3:44 AM (GMT -6)   
Some people do have joint or muscle pain; a lot of people have insomnia. That may be helped by taking the Prednisone early in the morning, although some of us still don't get much sleep while taking it. These are both considered "minor", short-term complications of steroid use.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from Entocort.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
"My life is an ongoing medical adventure"
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/5/2009 4:54 AM (GMT -6)   
I meant to say that last time I had a sinus infection they gave me Avelox and Prednisone (not Avelox and UC). Once again it is the middle of the night and I can't sleep at all!

Veteran Member

Date Joined Dec 2008
Total Posts : 3231
   Posted 4/5/2009 5:23 AM (GMT -6)   
Prednisone gave me muscle cramps. I would get them in yoga class. They were quite intense. The muscles that had cramped up would hurt for days afterwards.

I'm surprised that anyone would prescribe prednisone for sinus infections. I had a really bad sinus infection once. It was right after I got out of the hospital for pneumonia. I left the hospital earlier than my doctor wanted me to, because I was attending university and the semester had already started. The sinus infection was so bad the snot was completely yellow and stretchy like a rubber band. I felt like I was pulling rubber bands out of my nose. They gave me antibiotics for it. This was back in 1984. I guess they didn't prescribe prednisone for sinus infections back then. Thank goodness for that.
Joy - 47 yrs and counting
Colitis Dec 06 (also have IBS)
Currently in remission
Don't expect your doctor to cure your health problems. Your health is your responsibility.

Lexapro (for stress), Probiotics and Vitamins (a whole bunch of them)
Avoid HFCS, foods high in fructose, artificial sweeteners
When flaring: eat anti-inflammatory foods, avoid pro-inflammatory foods
Previous treatments: Fecal transplantation (worked), Prednisone (stopped working), Colazal (stopped working), Asacol (stopped working)

Regular Member

Date Joined Feb 2008
Total Posts : 214
   Posted 4/5/2009 11:20 PM (GMT -6)   

I never had the muscle pain/cramps, but I could stay awake forever while on prednisone.  It kindav made me crazy sometimes.



diagnosed 1998

now off prednisone and colazal

drink 1 Haldi daily to remain in remission


Veteran Member

Date Joined Mar 2009
Total Posts : 1439
   Posted 4/5/2009 11:55 PM (GMT -6)   
Insomnia is a pretty common side effect. Not sure about the muscle pain.
21, female, diagnosed 3/6/2009
Mild ulcerative colitis from rectum to mid transverse colon
Currently in remission
Currently taking Asacol (3x/day) and Calcium/D supplements

Regular Member

Date Joined Feb 2009
Total Posts : 114
   Posted 4/6/2009 7:35 AM (GMT -6)   
I had muscle pain, especially in my calves. Doctor said I should increase my calcium. She is also testing other levels, B12 etc.

I'm generally ok, but did have a couple bad days where I could barely walk.
Diagnosed U.Proctitis 07

Flare Feb 09 - Diagnosed with Severe Pancolitis
Remicade, 50mg Prednisone, Cortenema PM, 1g 5 ASA suppository AM

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 4/6/2009 11:04 AM (GMT -6)   
If the muscle pain is actually a cramp or "charley horse", it's probably low potassium. Prednisone messes with your sodium/potassium balance. Try drinking a glass of orange juice or eating a banana in the evening.
Moderate to severe left-sided UC diagnosed 2001.
Flared for 5 years, finally in remission with Remicade since March 2006.
Avascular necrosis in both shoulders is my "forever" gift from steroids.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. 
"My life is an ongoing medical adventure"

Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/6/2009 11:34 AM (GMT -6)   
I hadn't thought of potassium. I guess it's possible the potassium could be causing the muscle pain and the prednisone the insomina. I'll have to see what the doctor says Thursday.

Regular Member

Date Joined Mar 2009
Total Posts : 52
   Posted 4/6/2009 12:28 PM (GMT -6)   
I am lucky to sleep any more than 4 hours a night and that is with me taking two sleeping pills. I fall asleep late and once I wake up I am finished.

I also have muscle and joint pain. My ankles, calves, knees, hips, and shoulders are all causing me discomfort. The pain in my legs is the most bothersome and is there most often.

Prednisone isn't much fun but it does seem to be helping me.
Female, 41
1996 diagnosed proctitis (during pregnancy, just months after I quit smoking)
Mar 3, 2009 diagnosed ulcerative colitis - it got my entire colon - severe

Fighting my first major flare up of UC (but I think my first UC flare up was at the end of 2006, 2 months after I quit smoking again)
60 mg prednisone (started at 30 but was doubled immediately) Mar 5/09
salofalk enemas = 5-aminosalicylic acid (mesalamine) added March 24/09 after second colonoscopy showed not enough progress ( previously managed proctitis with same stuff as suppository and then enema in 06)

Veteran Member

Date Joined Aug 2008
Total Posts : 5975
   Posted 4/6/2009 3:20 PM (GMT -6)   
     I've been off prednisone since Nov 1st and still have insomnia.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/ see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

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