Wellbutrin XL and UC

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Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/5/2009 3:09 AM (GMT -6)   
I had been in remission for 4 years then I started taking Wellbutrin and a week later my UC started. Is it possible
it triggered the flare or just a coincidence?

Elite Member

Date Joined May 2003
Total Posts : 30986
   Posted 4/5/2009 2:44 PM (GMT -6)   
Probably coincidence.....why did you start Wellbutrin?
Many of us aren't able to recognise early symptoms especially if there's something else going on in our lives that's bigger and requires a lot of our emotional focus.

I flare when I'm on minimal meds and there's something emotional happening...some sort of crisis that I feel somehow helpless..etc.

*Heather* Status..Asacol  (3 x2 daily); Salofalk enemas nightly for flares, tapered to maintenance  mild flare nightly enemas
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/5/2009 8:19 PM (GMT -6)   
I was having memory loss. They did an MRI, no brain problems so the doc said it's depression. I was feeling for sad for no apparent reason at all.
I have a great life and I"m very happy, but I started to take the Wellbutrin and the sadness went away completely as did the memory problems.

Veteran Member

Date Joined Mar 2008
Total Posts : 678
   Posted 4/5/2009 8:27 PM (GMT -6)   
I know that SSRI's give me D but I believe that Wellbutrin is a different formula. Too bad about your UC flaring up, at least you aren't feeling depressed and your memory is improved. I was thinking of going on Wellbutrin myself.
31 yr old female currently breastfeeding (weaning so I can start 6mp)
Mild Pancolitis
I've had UC since 2000 but was in remission for most of those 8 years med free
Cannot tolerate mesalamine - starting 6mp soon

Regular Member

Date Joined Apr 2009
Total Posts : 208
   Posted 4/5/2009 8:39 PM (GMT -6)   
The Wellbutrin really made a difference, it gave me energy and made me "happy" right away. I'm thinking much clearer and not having any memory problems at all, so yes, that's great! It's very coincidental that my UC flared just a few days after I started the Wellbutrin

Regular Member

Date Joined Mar 2008
Total Posts : 113
   Posted 4/6/2009 8:25 AM (GMT -6)   
I've been on Wellbutrin XL for a couple of years and it doesnt' seem to effect my UC.
Diagnosed w/ UC in August 2007
Current status: In Remission since June 2008

4 Lialda/day maintenance, healthy diet

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