budesonide sp? aka endocort enemas needed to be mixed in the U.S.?

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Date Joined Feb 2007
Total Posts : 344
   Posted 4/5/2009 10:12 AM (GMT -6)   
My doctor has mentioned starting budesonide sp? aka endocort enemas. He said he is going to try to find a pharmacy that mixes it to the enema since its not available in that form in the states. Anyone familiar with this or the drug in general? He says it has a little steroid and would be a substitute for rowasa if it seems that i am allergic to it and it causes D since I've had it for while now. Thanks all!
UC diagnosed January 05
Past Meds: Azasan (Imuran) - piercing chest pains after six days so tried different brand aka Azathioprine - morning nausea /didn't really help after more than 6 months, dicyclomine (still flared), Remicade - 7 treatments (stopping because no dramatic changes), allergy shots (03-07), levbid, prednisone (been off since nov. 08!), rowasa
Current meds: Asacol 4 - 3x, Aciphex (acid reflux), canasa and rowasa alternating every other night, konsyl (fiber for bulking stool), multivitamin, caltrate 2x a day. probiotic (florasmart), astelin (nasal spray as needed for allergies), fosamax (bone density)

Regular Member

Date Joined Jul 2007
Total Posts : 102
   Posted 4/5/2009 12:38 PM (GMT -6)   
I've been using budesonide enemas by AstraZeneca because the mesalamine ones started causing bleeding for me. I'm in Canada though, so not sure what's available in the states. The ones I use aren't pre-mixed - I get them 7 enemas per box. The enema bottles have a solution of NaCl, preservatives and water. There's also a pack of budesonide tablets - you take the lid off the bottle, drop a tablet in and shake until the tablet dissolves. After mixing, the budesonide is 0.02mg/mL. The enemas are 100mL, so you get 2mg of the glucocorticosteroid per enema.
Ottawa, Ontario, Canada
-F/33 -diagnosed June 2006
-last 25cm of colon affected
-xylocaine enemas put me in remission
-Asacol 2 800mg pills 2x/day
-budesonide enemas every 4-5 days

Regular Member

Date Joined Nov 2008
Total Posts : 222
   Posted 4/5/2009 7:12 PM (GMT -6)   
Hi there. I am Canadian living in the States right now. Budesonide enemas are avaiable in Canada but are not available in the States. I am guessing that your doc is trying to find a compounding pharmacy that make them especially for you. Buudesonide is a a steriod that has alot fewer sides effects than a cort steriod because (I think I have this right but may be off) it is processed and more throughly by the liver than other steriods and therefore far less becomes systemic when it is used topically in the rectum. I asked my GI doc down here why it is not available in the US - he said he doubted the insurance companys would pay for it when cort enemas were available at a way cheaper price......too bad, because reduced side effects would be a nice option. jo
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