Is it too soon to see an improvement?

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Regular Member

Date Joined Jan 2008
Total Posts : 362
   Posted 4/7/2009 12:14 PM (GMT -6)   
After my colonoscopy a week ago today, where my GI *finally* told me where my UC was located(lower colon), he put me on the mesalamine enemas for 3 weeks.
I have been doing it faithfully every night.  Still blood and urgency.  Is it too soon to see some improvement?  Am I being impatient?
Ulcerative proctitis. On Asacol 3 3x a day, and Meslamine enemas nightly.
Blood is a bigger problem for me than D.

Forum Moderator

Date Joined Dec 2008
Total Posts : 16724
   Posted 4/7/2009 12:25 PM (GMT -6)   
I think it is different for everyone but have you seen even slight improvement? I get frustrated if the improvement doesn't come quickly. I hope you start feeling better soon. I don't have blood anymore but I still have urgency. I think urgency is probably the last symptom to go away, I've had no luck getting mine to disappear.

Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
Diagnosed with UC December 08 but had symptoms months ago - Treating with Asacol 400mg (9 a day)

Veteran Member

Date Joined Mar 2008
Total Posts : 2855
   Posted 4/7/2009 12:27 PM (GMT -6)   
I get mixed results with the enemas. Sometimes I can tell they are helping, other times it seems the flare is too stubborn or systemic for them to help any. At least they help clean me out the morning after!
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering. Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; eliminated all wheat/gluten from my diet. Probiotics (Ultimate Flora, 50 billion), trying Curamin. 
Flaring, seasonal? or supplements too harsh? Back on prednisone, tried to taper but now back up to 20-30 after several really bad days. Waiting for insurance decison on Humira...soon... 

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 4/7/2009 12:39 PM (GMT -6)   
I think you should have seen at least a small amount of improvement by now, especially as you're using asacol as well. I'd probably call your GI and let him know you're not improving at all.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, 40mg 30mg 20mg 15mg 10mg of Prednisone (quick taper), Culturelle probiotic, and Zoloft (25 mg).

Veteran Member

Date Joined Jul 2006
Total Posts : 1201
   Posted 4/7/2009 12:44 PM (GMT -6)   
My first diagnosis required taking the enemas twice daily (AM and PM). I saw almost immediate improvement, probably after a few days. I LOVED them! Asacol did NOTHING for me. Have you altered your diet at all? I found by trial and error over the years that severely limiting my sugar intake (including artificial sweeteners), grains and yeast-containing foods helped me feel much better and stayed feeling better. Everyone is different, I know, but perhaps you could consider making some changes to see if you also find relief in your symptoms. Are you on probiotics?

Regular Member

Date Joined Apr 2008
Total Posts : 460
   Posted 4/7/2009 2:29 PM (GMT -6)   
What about trying the steroid enemas? I have been using them for one week and I've noticed a huge improvement in my bleeding. I've always been a bleeder, I often have to go to the bathroom just to pass blood (4-6 times a day). Since I've been on the steroid enemas, I haven't had to go to the bathroom for that reason in about 3-4 days. I'm still having some bleeding with my stools but I'm not going to the bathroom and only having blood like I was a few days ago. Rowasa never did anything for my bleeding, I love the steroid enemas (as much as one can love an enema. lol).
Female, Age 38
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03, Diagnosed with UC 2/03
Current Meds:
Lialda, 6MP
Ferrex Forte
Acidophillus, Sacchromyces Boulardii, Oil of Oregano

Regular Member

Date Joined Jan 2008
Total Posts : 362
   Posted 4/7/2009 2:32 PM (GMT -6)   
I suggested the steroid enemas and he didn't seem to ready to go there yet, much to my disappointment. We'll see when I go back in May.

I have tried altering many foods and saw no difference.
Ulcerative proctitis. On Asacol 3 3x a day, and Meslamine enemas nightly.
Blood is a bigger problem for me than D.

Elite Member

Date Joined May 2003
Total Posts : 30986
   Posted 4/7/2009 5:09 PM (GMT -6)   
so, what exactly is the improvement you can say...still urgency, but with the same ## of bms daily? Same amount of blood? less, more because of pooling?

Any rectal discomfort?

Are you taking the Asacol as well as the enemas?

3 weeks should show you "some" improvement...but for some it can take a few months. I would say give it the best shot for at least another month...nightly.

*Heather* Status..Asacol  (3 x2 daily); Salofalk enemas nightly for flares, tapered to maintenance  mild flare nightly enemas
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

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