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cagio1
Regular Member


Date Joined Mar 2007
Total Posts : 56
   Posted 4/17/2009 10:55 AM (GMT -6)   
Hi All,
Need a little advice.  I have been on 6MP 50 mg for the past two years.  The doctor wanted me to increase to 75 mg to see if it will help in the relief of issues of flares etc.  I started the 75 mg on Sunday.  Since then I have become exceptionally fatigued, sore throat, fever, difficulty sleeping because I am getting up and down to go to the bathroom and diaharrea.  I am not sure this is from the 6 MP or maybe I have caught some type of "bug" or "cold".  My glands in my throat feel swollen.  Debating weather to go to local quick doctors office but... dont' know if I should just go back to the 50 and hope this wears off.  My GI is off today (Friday) so I will not be able to talk to him until next week.
 
Any advice???
Thanks
 
DX with (pan colitis) UC 9/02 while pregnant
Boniva Calcium multivitamin
Iron (when issues appear)
Librax, 3x day
Mild bronchial asthma too
OFF PRED !!!
6MP 50mg started beginning of July 08


Katmom
Veteran Member


Date Joined Mar 2008
Total Posts : 1202
   Posted 4/17/2009 12:24 PM (GMT -6)   
I am not a doc, but our experience has been that going up or down from 50 to 75 of 6mp has not been noticed. Hasn't helped, hurt or caused new symptoms. Sounds like a bug of a different type to me. Keep an eye out, as all kinds of crazy things happens. have you had your blood work done lately---is the 6mp at therapeutic levels and steady? My daughters numbers tend to fluctuate a bit.
Daughter,15 diagnosed 1-08 w/ UC .
Previous drug sampling: Asacol, Prevacid, Flagyl, Prednisone- 50mg to 0, 4 major flares '08.Hospital four x. Low residue diet,
6MP, Colazal , Cortifoam enemas,
Trying probiotics, Niferex, fish oil, Magnesium, Acupuncture.
Remicade 10mg per kilo@ 8wks, since 10-08. Still on 6mp and Colazal


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 4/17/2009 4:07 PM (GMT -6)   
It sounds like you got a "bug". I have never heard of increasing a dose of 6mp to cause enlarged lymph nodes. When was the last time you had your CBC checked? 6mp can lower your resistance to illnesses and you should go to the doctor to A) have your blood checked and B) to see if it's infection.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
To help Healingwell - click here: DONATE
 
 
 
 

 
 


cagio1
Regular Member


Date Joined Mar 2007
Total Posts : 56
   Posted 4/18/2009 6:58 AM (GMT -6)   
Thanks for your comments.  I do get bloodwork regularly.  Last one was a couple of weeks ago.  Everything was normal except my hemoglobin level was low (10.3) which is actually good for me (I normally am around 9-10 whether I am flaring or not)
I think you are both right... just a bug.  Seems there are alot of schools in my area that are closing down due to some type of viral infection with symptoms similar to mine.  (I saw this on the news last night)  I am a teacher...guess it was my turn to catch it.
Thanks for your input and time.
DX with (pan colitis) UC 9/02 while pregnant
Boniva Calcium multivitamin
Iron (when issues appear)
Librax, 3x day
Mild bronchial asthma too
OFF PRED !!!
6MP 50mg started beginning of July 08


Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5975
   Posted 4/18/2009 8:43 AM (GMT -6)   
     It can lower your resistance to infection and that is what you probably are suffering from, an upper respiratory infection.  I lowered my dosage from 75 mgm to 50 mgm one day and 25 the next for the reason that my white count was 2.4 while on 75 mgm and that is WAY too low.  It is now 2.9, not great, but better.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


Deacon Blues
Regular Member


Date Joined Oct 2006
Total Posts : 312
   Posted 4/18/2009 2:03 PM (GMT -6)   
Talked briefly with 27 yr old girl who had her leg amputated 1 month ago. Said she was taking 6MP and feels that it is the culprit along with her EX-GI Doctor. She will also be having her colon out soon. Be careful with these drugs people. Not trying to be an alarmist, let's just keep each other "on our toes" and we need to continue to be our own advocate with our doctors. There are probably many success stories w/6MP as well, just thought I would share this tidbit...wish I had more details...
Diagnosed with UC in Dec of 1999
PANCOLITIS-mild to moderate (remission for 2 years +!!??...i don't know...I am just SO happy when I have a good day!!)
3X400mg Asacol 3x per day
Mild flares a couple times a year
46 yrs old


kops2da
Veteran Member


Date Joined Jun 2008
Total Posts : 2865
   Posted 4/18/2009 2:49 PM (GMT -6)   

Not getting alarmed but wondering how do we know - assuming our routine blood tests are ok - what might be coming in the future.  I feel, at age 69, not as threatened as you young people.... BUT - I would like to be here to be say 80 in fairly good health.  I am obese and that will be against me.  Maybe when I get off the prednisone I can lose some weight - once again!

As for me, I have to trust taht my doc is doing for me what is necessary for the UC.  He certainly has been trying. 

ElaineNY


 
Senior - New diagnosed with proctosigmoiditis - 6/2008  Cannot tolerate mesalamines, Canasa, etc. Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred.
Started on prednisone Feb.7, 2009 - tapering to 20 mg. for two more weeks. Bleeding returned - no call back from doc so I upped prenisone to 25mg. on my own - 6MP - 50 mg. 4/2/2009 
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.
 
 
 


Delarge
Regular Member


Date Joined Mar 2007
Total Posts : 157
   Posted 4/18/2009 8:32 PM (GMT -6)   
The symptoms you're experiencing might be attributable to a mild bacterial/viral infection, or myelosuppression. I would request blood work and a throat swab as soon as possible just to be cautious.

Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5975
   Posted 4/19/2009 2:11 PM (GMT -6)   
     Deacon Blues....blaming 6MP for leg amputation?  What happened to this girl?  I saw a GI surgeon last year in addition to my regular GI doctor, just for another opinion because I was so darn sick.  The surgeon was totally against my having my colon removed, said I had mild/moderate ulcerative proctitis and was really pro 6MP.  He said in his years of practice (and I assume it must be over 30), he has seen a lot of positive results with patients on 6MP.  I was very concerned about developing leukemia or lymphoma but he assured me that he has only come across one patient who developed lymphoma while on 6MP and who was to say this patient wouldn't have developed lymphoma anyway?  I know at least four people with lymphoma and NONE of them ever took 6MP.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


Deacon Blues
Regular Member


Date Joined Oct 2006
Total Posts : 312
   Posted 4/19/2009 2:47 PM (GMT -6)   
Christine1946 said...
</b> Deacon Blues....blaming 6MP for leg amputation? What happened to this girl? I saw a GI surgeon last year in addition to my regular GI doctor, just for another opinion because I was so darn sick. The surgeon was totally against my having my colon removed, said I had mild/moderate ulcerative proctitis and was really pro 6MP. He said in his years of practice (and I assume it must be over 30), he has seen a lot of positive results with patients on 6MP. I was very concerned about developing leukemia or lymphoma but he assured me that he has only come across one patient who developed lymphoma while on 6MP and who was to say this patient wouldn't have developed lymphoma anyway? I know at least four people with lymphoma and NONE of them ever took 6MP


Well I tried to make sure that I had an implied disclaimer in my assertions...I WISH I HAD MORE INFO about HER CASE! I was just sharing "what I had been told" by the young lady. I have not done my own research on 6MP, I was just offering a tidbit of info for any of us that might be taking it or thinking of taking it. NOT trying to insight fear, just encouraging extensive research. No harm intended. I did mention that there are many success stories as well...:-)
DB
Diagnosed with UC in Dec of 1999
PANCOLITIS-mild to moderate (remission for 2 years +!!??...i don't know...I am just SO happy when I have a good day!!)
3X400mg Asacol 3x per day
Mild flares a couple times a year
46 yrs old

Post Edited (Deacon Blues) : 4/19/2009 1:50:30 PM (GMT-6)

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