Hi guys and gals,
I'm new to this site. This is my first post, but I've read many of your posts here over the years. As is probably typical for new members, I finally joined because of increasing problems...
So, first, some history: I've have UC since 1992. Luckily it's never been particularly bad - mainly just a nuisance. I've also been fortunate that low doses of sulfasalazine has kept the UC in check since then. For many years I was only taking 500 mg once daily. And every year or so during that time I would try to stop taking it entirely, but my UC symptoms would invariably return after a month or two. And then upping the sulfasalazine and adding Rowasa enemas at night for a month would return me to normal fairly quickly.
Since 2006 however, flare-ups have been harder to control. I've had to remain on increasingly higher doses of sulfasalazine: first 1 gm daily, then 2 gm, then 3 gm. Most recently, I was on 3 gm daily for 8 months, and then had another flare-up. Going to 4 gm daily, along with 6 weeks of nightly Rowasa enemas brought it under control. So, I stopped the Rowasa, and have been on 4 gm sulfasalazine daily alone for the past 6 weeks. But it feels like my symptoms are slowly returning yet again.
Now, my gastro doc was reluctant to even put me on 4 gm daily - ideally he wants me to be on only 3 gm max. If I can't soon return to 3 gm daily, he wants to switch me to either Asacol or generic Colazal, which supposedly have less side effects and so can be taken in higher doses.
The problem is, I've never had any side effects from sulfasalazine all this time, even at 4 gm daily. Also, Asacol is about
12x more expensive and generic Colazal about
7x more expensive then generic sulfasalazine.
Does anyone here have any experience with doses of sulfasalazine higher than 4 gm daily?
45 year old male. Ulcerative Colitis since 1992.
Mostly in remission from 1993 - 2006 on 500 mg sulfasalazine 1x daily.
From 2006 to present, fight flare-ups by increasing sulfasalazine, along with
Rowasa enemas at night as needed.
Currently on 4 gm sulfasalizine per day, but still have mild UC symptoms.
Post Edited (john496) : 4/17/2009 4:03:36 PM (GMT-6)