Weaning off 6 MP

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New Member

Date Joined Mar 2009
Total Posts : 6
   Posted 4/21/2009 9:52 AM (GMT -6)   
I have been coming off the 6mp for the last three weeks. I am so far doing okay except that my joints are really hurting. Not so bad I can't live with it but wondered if there is anything I can do for it.

Veteran Member

Date Joined Mar 2008
Total Posts : 678
   Posted 4/21/2009 10:01 AM (GMT -6)   
Just curious as to why you are weaning off of 6mp?
31 yr old female currently breastfeeding (weaning so I can start 6mp)
Mild Pancolitis
I've had UC since 2000 but was in remission for most of those 8 years med free
Cannot tolerate mesalamine - starting 6mp soon

Regular Member

Date Joined Jan 2008
Total Posts : 381
   Posted 4/21/2009 10:20 AM (GMT -6)   
Are we supposed to wean from 6mp- I didnt. I just stopped taking it per the doctor and I didn't experience any side effects at all.
Jackie, 43
Pancolitis, DX October 06

Lexapro, Synthroid, Protonix,
Tapering prednisone down to 10 mg

Surgery March 13th- Total Colectomy
Jpouch surgery to be done in 3 steps

Eva Lou
Veteran Member

Date Joined Sep 2006
Total Posts : 3440
   Posted 4/21/2009 10:49 AM (GMT -6)   
there's no need to wean off 6MP/Imuran- you can just stop taking the med. So unfortunately, your joint pain is probably not caused by that.

diagnosed with UC '02
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
various probiotics
Fiber supplement

New Member

Date Joined Mar 2009
Total Posts : 6
   Posted 4/21/2009 10:58 AM (GMT -6)   
I am completely off it now. They diagnosed me with ulcerative proctitis back in June. It got really bad and it caused 3 fistulas. They had me on prednisone and 6mp. They took me off of the prednisone and left me on the 6mp. I had to have a illeostomy in Sept. They did rectal surgery to correct the fistulas. I am suppose to have the illeostomy reversed in June. I just don't have any energy and my joints are somewhat achy. I didn't know if it was because I am not taking the 6mp anymore. shocked

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 4/21/2009 11:19 AM (GMT -6)   
So did you decide to take yourself off of the 6MP? It's interesting that they chose to use 6MP as a maintenance med off the bat instead of trying a 5-ASA instead.

Did your doctor discuss maintenance dosing with you? It's generally recommended that people with UC stay on a maintenance dose of medication to stay in remission. And yes, coming off of the 6MP could be causing your joint pain, as it's a fairly common symptom that people with UC have.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, 40mg 30mg 20mg 15mg 10mg 10mg of Prednisone every other day, Culturelle probiotic, and Zoloft (25 mg).

New Member

Date Joined Mar 2009
Total Posts : 6
   Posted 4/21/2009 11:42 AM (GMT -6)   
I hated being on the 6mp and prednisone........They didn't think it was too bad and wanting to try to come off all meds.......I have Ulcerative Proctitis not colitis.....I have to go back to the doctor next week and hope to resolve some of my questions

Veteran Member

Date Joined Jun 2008
Total Posts : 2865
   Posted 4/21/2009 11:50 AM (GMT -6)   

I am on both prednisone and 6MP.  I need knee replacement surgery and my gastro doc agreed that no problem after I go into remission to stop 6MP for a while to get my system back to "normal", having the surgery and then returning to 6MP at some point for maintenance of UC.  I will probably stay on small dose of prednisone while having surgery.  Time will tell.


Senior - New diagnosed with proctosigmoiditis - 6/2008   Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred. No mesalamines!!
Started on prednisone Feb.7, 2009 - tapering to 20 mg. - upped prenisone to 25mg. on my own (bleeding returned) - 6MP - 50 mg. 2/28/2009 
75mg. 6 MP added on 4/8/2009 - waiting for CBC and Prometheus tests
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.

Veteran Member

Date Joined Aug 2008
Total Posts : 5947
   Posted 4/22/2009 6:36 AM (GMT -6)   
     LP33, I also have ulcerative proctitis.  I would LOVE to be off the 6MP.  How did you manage to talk your GI doctor into that?  Mine is a regular pill pusher.  I lowered my dose from 75 mgm to 50 mgm one day and 25 the next for the reason my white count was down to 2.4 on the 75 mgm.  It is now 2.9.  I'm still not happy with that low of a white count but my doctor isn't concerned.  He said that is how he knows the 6MP is doing its job.  I've been on 6MP for over five years.  It really hasn't kept me out of flares either.  I also take Colazal.  The doctor said the Colazal and 6MP are keeping my colitis from "creeping up" further into my colon.  Back in 98 was when I was diagnosed and it still is confined to my rectum.  Right now enjoying remission since Nov 1st.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

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