Switched from Colazal to Sulfasalazine, big improvement.

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Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 4/23/2009 9:22 AM (GMT -6)   
I was alway under the suspiction that Colazal was either making my symptoms worse or just not helping. I switched to Sulfasalazine (generic) and the next day immediate improvement. I went poo completely normal this morning, more normal than I have in months on Asacol and then Colazal. I only took 2 Sulfa yesterday after taking 3 the day before, I dropped dosage to see if it was causing a few random mild abdominal pains, nothing real bad just annoying. It did seem to help cutting dosage down.

Basically I just want people to know as long as your not allergic to Sulfa, don't be afraid to try the older and MUCH cheaper drug Sulfasalazine. I think it is doctors last choice as the drug companies push the newer more expensive drugs first whether they work any better or not.

aned
Regular Member


Date Joined Mar 2009
Total Posts : 105
   Posted 4/23/2009 3:52 PM (GMT -6)   
Thanks for the info. I am thinking of switching as well because Colazal does not appear to be working.
37 y/o female
non-specific colitis dx. 2007
ulcerative colits dx. 2009
diverticular disease dx. 2009
Asacol-failed
Entocort-failed
Colazal-current, but not working yet


mudua
Regular Member


Date Joined Apr 2007
Total Posts : 459
   Posted 4/23/2009 4:08 PM (GMT -6)   
Zippy123 said...
I was alway under the suspiction that Colazal was either making my symptoms worse or just not helping. I switched to Sulfasalazine (generic) and the next day immediate improvement. I went poo completely normal this morning, more normal than I have in months on Asacol and then Colazal. I only took 2 Sulfa yesterday after taking 3 the day before, I dropped dosage to see if it was causing a few random mild abdominal pains, nothing real bad just annoying. It did seem to help cutting dosage down.

Basically I just want people to know as long as your not allergic to Sulfa, don't be afraid to try the older and MUCH cheaper drug Sulfasalazine. I think it is doctors last choice as the drug companies push the newer more expensive drugs first whether they work any better or not.
Sulfasalazine is the first drug I took when I was diagnosed with UC. I worked for me for six months and than I started to get 'light headed', nauseaus and I felt like I would faint at any time. My doctor told me that those symptoms were the long term use of Sulfasalazine or salazopyrin as it's called in South Africa. I than switched on differtent medications which did not really help me much.
 
I don't think that Sulfasalazine can be used as a long term treatment of UC because of it's side effects but it's fantastic for the first six months
 
 

rdm
Regular Member


Date Joined Apr 2006
Total Posts : 229
   Posted 4/23/2009 5:17 PM (GMT -6)   
Mudua

Your experience may be unique, most people if they have serious side effects from sulfazalazine have them when beginning the drug, that was my experience. I had head aches which went away in a few weeks. Your supposition that this is a short term med based on your own experience of "side effects" is neither borne out by my experience or that of many others on this site. Yes, all drugs may loose there efficacy at some point. Regardless, so far after 25 years this particular drug is still working for me with the only side effects yellow orange pee and increased sensitivity to the sun. Also remember you must take folic acid with this drug as it reduces the intake of this vitamin.

rdm

christianbcmom
Regular Member


Date Joined Apr 2009
Total Posts : 69
   Posted 4/23/2009 6:22 PM (GMT -6)   
Sulfasalizine works great for me; however, it doesn't work well for my husband. He got really bad headaches from it like some of the others mentioned. However, worked great for me!! So good luck with it!! I still use it if I start to have problems.

Alaina

joy44
New Member


Date Joined Jun 2006
Total Posts : 17
   Posted 4/24/2009 7:28 PM (GMT -6)   

I Just started on sulfasalizine today. My doc did not precribe any folic acid but I do remember at my visit he said I would have to. I will call  him on monday.

In the mean time can you all tell me how much folic acid I should be taking with this drug. Is it percription your getting or do you buy it over the counter, and how much should I take.

Thanks,

Joy


Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 4/24/2009 8:07 PM (GMT -6)   
My doctor didn't say a thing about folic acid. I do take a multivitamin that has extra folic acid hope that is enough.

rdm
Regular Member


Date Joined Apr 2006
Total Posts : 229
   Posted 4/24/2009 8:31 PM (GMT -6)   
Most muti vitamins have 400 mcg of folic and that should be enough, a multivitamin is probably a good idea for people with active UC. You can buy folic as 400 mcg and 800 mcg. I use the 800 but only due to some lapses in taking it, 400 per day should be adequate unless your ordinary diet is already deficient.
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