two immune suppressants...is that right?

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UC spouse
Regular Member


Date Joined Feb 2008
Total Posts : 70
   Posted 4/25/2009 5:05 PM (GMT -6)   
My husband has had pancolitis for two years and has not gone into remission yet.

He has a new doctor that is prescribing him Imuran for 30 days in addition to the Humira he has been on for a year. He has also been taking 4 Asacols a day for a week now. The Asacol seems to have reduced his trips to the bathroom, so I was wondering if it would be better to increase the Asacol instead of starting another immune suppressant. I am worried that he will be on two immune suppressants. That might open up a whole new can of worms. His doctor claims, "he needs to get this monster under control." Has anyone been on two immune suppressants simultaneously?

Any comments/advice would be much appreciated.

Thank you,
Concerned Wife

Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5975
   Posted 4/25/2009 5:39 PM (GMT -6)   
     Well, I have been on prednisone along with 6MP several times.  They both suppress the immune system.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


Liza D
Regular Member


Date Joined Apr 2009
Total Posts : 166
   Posted 4/25/2009 9:21 PM (GMT -6)   
I was on Remicade and 6MPs. Not a good result. My white blood cells fell so fast the doc called me once he got my labs back. They seem to have made me intolerant to both- the Dr took me off both and we had to start from square one with Lialda. But, it looks like other people have been able to maintain on 2 immune suppressants. But watch the white blood cells.

Good luck to you and your husband. You seem to be a great advocate!
UC (Pancolitis... 90%!) December 2001
Arthritis (2003)
Upper GI Ulcer (2006)
Osteopenia (2008)
Depression/Anxiety (2002)

Meds:Bump up every couple years... You name it, I've used it! Sulfasalizine, Asacol, Rowasas, Pentasa,
Remicade, 6mps... And now it looks like the once daily Lialda taken twice a day isn't enough...
Here comes Humera.

Soon to be mom- hopefully! As long as this flare dosen't take me out...


Dr-A
Veteran Member


Date Joined Jul 2006
Total Posts : 2105
   Posted 4/25/2009 10:38 PM (GMT -6)   
Prednisone, Azathioprine, and golimumab. Three at one time.
Proctitis DX 1999, Pancolitis DX 2008
Immuran
Golimumab study (100mg every 4 weeks)
L-Glutamine 5000 mg + 600 mg pyridoxal alpha-ketoglutarate
Probiotis/VitD3+Ca/1000mg DHA


Sweetie31105
Veteran Member


Date Joined Aug 2008
Total Posts : 903
   Posted 4/25/2009 10:39 PM (GMT -6)   
I am on Humira, and I was on Imuran for a year and a half with the Humira. For me it wasn't that big of a deal. It is an immune suppressant, but I didn't feel the effects of it. I work with preschoolers, and didn't catch their illnesses, but I was extra cautious when I did get sick. While on the Imuran since it was a daily pill, I added some extra vitamins because of the immune suppressant. Just a suggestion.
27 year old, Married, Female.
Diagnosed with UC since March 2007

Taking Humira and Imuran since May 2007 (Currently in remission since May 2007)
Taken off Imuran 1/15/09
Only taking Humira.

Can't take Asacol, Allergic to Remicade

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