How long should it take for meds to kick in?

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Regular Member

Date Joined Apr 2009
Total Posts : 26
   Posted 4/28/2009 6:45 AM (GMT -6)   
My son has been on Liadal for a month or so (started with 3 and is now up to 4 a day). Just haven't seen any big changes in his U/C. Last Thursday doc started him in 40mg of Prednisone. Again, a bit of an improvement but nothing great. Just wondering if these drugs are not for him. He is still running to the bathroom many times a day, and even through the night. He's not really eating much, very light meals but drinking a lot. He's only 19, and is so thin anyway, about 6' and was up to about 155, but is now about140. When do docs start to reallly worry about he weight loss? His doc isn't panicking yet, but me as a mom just wants to cry when I see him without his shirt. I feel so helpless and just want him to feel better soon. This has really been his first bad flare since being diagnosed about 6 months ago, so we just didn't know what to expect. I read all of these posts about how Prednisone and Liadal are working wonders for people, and I just want something to work for my son. Thanks for any suggestions.

Regular Member

Date Joined Jan 2008
Total Posts : 381
   Posted 4/28/2009 6:50 AM (GMT -6)   
First of all, I am so sorry that your son is going through this.

THe Lialda should have started working by now. I took it for a long time and it never worked for me- but I kept taking mostly for fear I would get even sicker if I stopped it.

Prednisone should start working within a week. I usually saw improvement after taking pred after a few days. 40 mg is the usually starting dosage. It should start working soon.

Has he tried rectal meds? It works well for some people.
Jackie, 43
Pancolitis, DX October 06

Lexapro, Synthroid, Protonix,
Tapering prednisone down to 10 mg

Surgery March 13th- Total Colectomy
Jpouch surgery to be done in 3 steps

Regular Member

Date Joined Apr 2009
Total Posts : 26
   Posted 4/28/2009 6:55 AM (GMT -6)   

Thanks Jackie,

Doc is checking in with him daily, so I think that he may go a different way if the Prednisone doesn't start working soon. Will let you know how he's doing. By the way, my  husband had the colectomy about 10 years ago, never got the other surgeries, so he still wears a bag. We don't have a problem with it. Just that he is healthy is all I care about. We just wonder if Adam may have inherited U/C from his dad. Seems very coincidental.

Take care,

Regular Member

Date Joined Sep 2008
Total Posts : 153
   Posted 4/28/2009 7:00 AM (GMT -6)   
I'm on Lialda, and it doesn't do too much for me. I do notice an increase in symptoms if I don't take it. But when I do take it, it just sort of maintains whatever state I happen to be in at the time. Last summer, I had lost 30 lbs due to my flare-up, and after Lialda and Prednisone not having any major impact, my dr started me on Remicade. It worked well for a while - never got fully into remission, but I got to a point where things were tolerable and manageable with no blood. Now I'm in another flare up though and after regaining the 30 lbs last year, I have now lost 20 lbs. I'm not sure what the next step is for me medication-wise. I'll be going in for another colonoscopy this week.

Best of luck to your son.
Diagnosed w/IBS: Oct. 2006
Diagnosed w/UC: Jan. 2007 (proctitis), July 2008 (pancolitis)
Medications: Canasa (helped the first flare when it was just proctitis); Rowasa enemas (did not help as the following colonoscopy confirmed pancolitis); Lialda (2 pills in the morning, 2 pills in the evening, soon to be 2 pills in the morning only once I'm off steriods); Prednisone; Protonix (only took while on prednisone); Remicade infusions, started at 5mg/kg (Aug 2008), increased to 7.5mg/kg (March 2009), increased to 10mg/kg and increased to every 6 weeks (April 2009) - 7 infusions so far, next infusion on 5/28 continuing every 6 weeks; Zyrtec-D (for allergies); Toprol (a generic form, 25 mg, for a rapid heart rate)
Supplements: Women's One-a-day multi-vitamin; Super B-complex w/vitamin C, Iron supplements, Omega-3 Fish Oil (coated, not sure how much except one soft-gel daily), Aloe Vera supplement (two daily), Acidopholis, Probiotic Align
Diet: Spinach and Sunflower seed butter diet (starting 3/21/09) (will try again once I can eat normally again)
Current Status: April, 2009 - suffering another flare-up :(

Forum Moderator

Date Joined Mar 2003
Total Posts : 10407
   Posted 4/28/2009 7:19 AM (GMT -6)   
Luvfraz, there is a known hereditary component to IBD. It isn't directly inherited, but people with a relative who has IBD are more likely to get it themselves. Current thinking is that UC is an autoimmune disease for which some people have an inborn predisposition, but it takes other, not fully understood, triggers to activate the disease.

Your son is lucky to have more choices than were available a decade ago, and there are new treatments being developed all the time. Hopefully he will find the solution that works for him, and soon be feeling better.
Moderate to severe left-sided UC diagnosed 2001.
Flared for 5 years, finally in remission with Remicade since March 2006.
Avascular necrosis in both shoulders is my "forever" gift from steroids.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. 
"My life is an ongoing medical adventure"

Forum Moderator

Date Joined Dec 2008
Total Posts : 15909
   Posted 4/28/2009 8:02 AM (GMT -6)   
I think it is different for everyone - don't get discouraged. I have seen some people mention that Lialda or 5ASAs don't help them at all. I guess different peoples IBD is healed by different things. I consider myself fortunate that mine has responded to Asacol.
Do you know which part of his intenstines are affected? I was using Asacol alone and it took Asacol + rectal suppositories to stop the bathroom trips and bleeding. I do think with 40mg pred he should see improvement. I don't know what the highest dose of pred is but 40 is pretty high as far as I know and that plus 4 tabs of Lialda a day is a high dose of drugs. If you don't see improvements soon, you may want to move on and explore some of the other options. If I were in that position (and I am sure I may be some day) I would be frustrated and upset too. I hope you can find a solution quickly. I was 100 pounds a few months ago - fast forward to now, I am 116 and look healthy. You will find a solution and you will be surprised how quickly he turns around. Please keep me updated.
Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
December 08 - Began treating with Asacol 400mg (9 a day)

Regular Member

Date Joined Apr 2009
Total Posts : 31
   Posted 4/28/2009 8:48 AM (GMT -6)   
Hello Luvfraz,
Have you considered a special diet for your son?
There is a book called Breaking the Vicious Cycle by Elaine Gottshaul. It will worth taking alook. there is a website where you can read up on this specific diet.
hope ur son feels well soon
31 UC

Regular Member

Date Joined Apr 2009
Total Posts : 26
   Posted 4/28/2009 12:18 PM (GMT -6)   

Called the doc today, and he is actually taking him off of the Liadal for a few days to see what happens, and keeping the Prednisone going. Also starting him on some Probiotics as he said they are seeing some success with them. (At least he is a doctor that is open to them) He is also ordering a test of Adam's stool today, to see if there is any infection going on. I am praying that we turn this corner soon, as his weight loss is terrifying me. Hospitalization is the next horrible step, but doctor still thinks we are not close to that yet. He doesn't want to put him in the hospital as long as Adam is drinking and able to eat just a little bit. Does this all sound logical? My head is spinning today as I try to function at work, not knowing if we are doing the right thing. I have to trust his doctor not panicking right now, and trust that Adam will be better soon.

Thank you all for your support.


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