Creating Mesalamine suspensions - home made enemas..... advice please!

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Chicken
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 4/28/2009 11:22 AM (GMT -6)   
Hi people!

I was diagnosed with UC about a year ago, and I'm currently on my second course of steroids. I currently live in Japan, but I plan to go on a cycling trip across South East Asia in a few months. I need to keep taking the enemas, but they are, of course, impossible to carry with me on a bike (the trip will take months!) so I need a portable solution.

My plan is to use a small bulb syringe (or douche) and to crush generic Mesalamine to a powder, and suspend it in mineral/filtered water.

There are unknowns here.... Please advise if you can.

1. Is it dangerous to use mineral/filtered water in place of ph neural or saline?

2. I understand that the tablets have microcapsules, which only deliver their payload when coming into contact with bacteria in the intestines. Is this true?

3. If #2 is true, then will crushing a tablet using a pestle and mortar be sufficient to release the useful drugs, or, will the capsules still come into contact with the relevant bacteria in the lower intestines, if injected in solution?

4. I can see particles floating around inside the Pentasa enemas I am prescribed. Is this the same as a Pentasa capsule that has been crushed, or different!?

Many thanks for any suggestions or criticisms.

Chicken.

Chicken
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 5/2/2009 9:48 PM (GMT -6)   
Further to this:

I've been asking around, I've spoken to a couple of doctors, and no one can give me a straight answer. The doctors I have spoken to say that, there's no reason why it wouldn't work, but that I should check with a pharmacologist, as the knowledge is beyond their remit.

Unfortunately, I'm living in Japan, and my language skills leave much to be desired. Is there anyone out there who can help put me in touch with a pharmacologist!?

Rio in Maryland
Veteran Member


Date Joined Nov 2007
Total Posts : 891
   Posted 5/3/2009 10:08 AM (GMT -6)   
My doctor had told me to try home-made mesalamine enemas a while back.

He's well-recognized in the field and has been a GI specialist for a while, and mentioned that back in the day, a lot of people made home-made enemas using mesalamine (or was it sulfasalazine?) and even methylprednisone.

I used sulfasalazine and distilled water. I crushed the tablets with a pestle & mortar, warmed the water up and then mixed it with the crushed powder, and then let the whole mixture cool down to luke-warm before using the enema.
Rio, 33 year old male. Diagnosed with UC in 2006
100 mg Azathioprine, 4800 mg Asacol
VSL#3 x 3 times a day, Metamucil wafers
Vitamin E enema or Mesacol/Asacol enema at least once a week
Spinach & sunflower seed diet


Chicken
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 5/3/2009 11:16 AM (GMT -6)   
Hi. Thanks Rio.

Was there any reason for warming the water?

Rio in Maryland
Veteran Member


Date Joined Nov 2007
Total Posts : 891
   Posted 5/3/2009 1:59 PM (GMT -6)   
He recommended warming the water as he felt that when inserting the enema, a warmer temp. closer to the body temp. would make it more comfortable to insert than colder water.

I'm not sure if warmer water made a difference, but it may have helped dissolve the crushed mixture better.
Rio, 33 year old male. Diagnosed with UC in 2006
100 mg Azathioprine, 4800 mg Asacol
VSL#3 x 3 times a day, Metamucil wafers
Vitamin E enema or Mesacol/Asacol enema at least once a week
Spinach & sunflower seed diet

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