Can't tolerate 5-ASAs - what's next?

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Regular Member

Date Joined Apr 2009
Total Posts : 30
   Posted 4/29/2009 1:22 PM (GMT -6)   
My dr. has recently deduced that I can't tolerate the 5-asas. I've tried loads of things, most recently apriso, dipentum, colazal but I have terrible reactions to all of them. Right now I'm on prednisolone and doing fine just on that, but I know I will need to add something else before I'm completely tapered off. For those who can't tolerate 5-ASAs, what is generally the next drug that is tried? Right now I'm just in contact with my dr. for v. short phone conversations each week where he checks in to see how I'm doing and then reduces the pred.-so i'm not sure when he will try to add in another medication. Would love to know what others have done  and what's typical beforehand.

Veteran Member

Date Joined Mar 2008
Total Posts : 678
   Posted 4/29/2009 1:46 PM (GMT -6)   
I cannot tolerate 5ASA's either. Your GI will probably have you try 6mp or Imuran next.
31 yr old female currently breastfeeding (weaning so I can start 6mp)
Mild Pancolitis
I've had UC since 2000 but was in remission for most of those 8 years med free
Cannot tolerate mesalamine - starting 6mp soon

Veteran Member

Date Joined Feb 2009
Total Posts : 7150
   Posted 4/29/2009 2:02 PM (GMT -6)   
Most GIs will prescribe an immune suppressant like AMK77 said. However, some doctors will go ahead and prescribe Remicade instead of 6MP or Imuran.
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 4/29/2009 3:47 PM (GMT -6)   

I cannnot take 5ASA's either.

Imuran did not help me much

I was then to go on remicade, then humira (if I could get on a study or approved).

Between Imuran and Remicade I got put on Cellcept for my kidneys and it can also help a small portion of UC patients.  I am in remission w/that and 7.5 mg of pred. 

Beth, 33 ~ hoping to taper pred successfully, wish me luck!
Major Flare Sept/Oct 07.  Flare May 08 (from aspirin?).
UC dx'd 03/00 Proctosigmoiditis; Pancolitis since 09/07
Can't take anything b/c I am on Cellcept for my kidneys (can possibly help UC) Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd 09/07. Close to remission since 9/08.
Cellcept 1000mg 2xday, Prednisone 7.5mg 1xday, Lipitor 40mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs (sulfasalazine, asacol).  Do you have edema? If so, check your blood protien level!

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