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Veteran Member

Date Joined May 2007
Total Posts : 646
   Posted 4/29/2009 6:41 PM (GMT -6)   
Hi everyone,
I am ten weeks pg and in a mild flare.  My doc just prescribed cortenemas.  Although I will take them regardless, I am truly terrified about the side effects.  Anything more than 30 mg of Prednisone orally and I had every horrible side effect - acne GALLORE, HUGE moon face, insomnia, joint pain, nausea, muscle atrophy, the list goes on.  Are the cortenemas going to bring on all of this????  I am so scared of looking and feeling like a monster again shakehead .

Diagnosed April 1998 - Pancolitis
Currently on (per day):
Pentasa 3 gms
Imuran 75 mgs

Veteran Member

Date Joined Jul 2006
Total Posts : 2105
   Posted 4/29/2009 6:47 PM (GMT -6)   
I have done two cortenemas a day at times with no side affects. Since it is being administered to that portion of the body it isn't as systemic as the regular oral pred.
Proctitis DX 1999, Pancolitis DX 2008
Golimumab study (100mg every 4 weeks)
L-Glutamine 5000 mg + 600 mg pyridoxal alpha-ketoglutarate
Probiotis/VitD3+Ca/1000mg DHA

Veteran Member

Date Joined Jun 2008
Total Posts : 742
   Posted 4/29/2009 8:50 PM (GMT -6)   
Dr-A is right - this is not a systemic drug.  It really only effects the area of body it's applied to, with a minimal amount getting into your bloodstream (my doc told me this).  I used cortenema for quite a while with absolutely no pred-like side effects. 

DX:  Pancolitis as of 9/08 (Proctitis as of 1/08) and IBS
Status:  Remission
What Worked:  Spinach/Sunflower Seed Diet & IBS Diet (
What Didn't Work:  Canasa suppositories, Cortifoam, Prednisone, Colazal, Symex DuoTabs, Rowasa, Bentyl, Cortenema, Asacol, Iron, Zoloft, Acidophilus.

Veteran Member

Date Joined Dec 2007
Total Posts : 536
   Posted 4/29/2009 9:29 PM (GMT -6)   
I have mild cortenema side effects such as slight moon face and agitation, insomnia - but absolutely nothing compared to pred, and they go away really within a few days of tapering the enemas. The enemas cause D and worse gut issues the first little while you take them, but then kabam, they start to do good. How long are you on them? For me, it has been 2 weeks and then taper for 2 more.
23 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics. Latest issue is endless diarrhea without blood or mucous.


Regular Member

Date Joined Jan 2009
Total Posts : 498
   Posted 4/30/2009 1:55 AM (GMT -6)   
Mitzo is right. Cortenema is lesser evil compared to oral Pred. I had it for quite some time, may be months. I used to have slight moon face and palpatation. The side effects seem to be lesser as compared to oral Pred.
45 years Male Attorney
Diagnosed UC October 1989
Had two stage J Pouch Surgery Nov 2005; Take Down March 2006
Complications after surgery - Incisional Hernia and Ano Fistulas
"There are only two ways to live your life. One is as though nothing is a miracle. The other is as though everything is a miracle: Albert Einstein
"What you are aware of you are in control of; what you are not aware of is in control of you."

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 4/30/2009 10:22 AM (GMT -6)   
You only get around 5-8mgs of steroid that enters your bloodstream and the side effects, if you get any, are not nearly as bad as the oral. It was 6 months of almost constant use that I started showing side effects such as moonface.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
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