Asacol not dissolving?

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fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 4/30/2009 11:22 AM (GMT -6)   
Ok, so I know that GIs say that just because you see the Asacol capsules in the toilet doesn't mean that it's not dissolving, that it's just the shell.  However, I'm not convinced that mine are always dissolving.  A few times, I've carefully fished a capsule out of the toilet (gross, I know, but they were on the surface, I used TP, and I washed VERY well afterward) because I noticed some white stuff leaking out of the capsule.  After fishing them out, I smooshed them around with TP and found that there was quite a bit of white stuff (I assume it was a powder before it got wet) left in the capsule. 
 
Has anyone else had this happen?  If so, have you talked to your GI about it and what did they say? 
 
I see my GI again in early June and I plan on talking to him about this and seeing if he thinks it would be worth trying Apriso as it starts dissolving at a lower pH.  My symptoms aren't that bad right now (loose, non urgent BMs 4-6x/day) and I can function normally, but I probably still have some inflammation, which I'd rather not have as I assume continuous inflammation increases the risk of colon cancer. 
 
Thoughts?
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).


Deacon Blues
Regular Member


Date Joined Oct 2006
Total Posts : 304
   Posted 4/30/2009 11:29 AM (GMT -6)   
I HAVE had this happen, probably frequently as well. I have asked my Doc and he says that the medicine is getting out of the capsule..I TOO AM NOT CONVINCED. I don't know anything about Apriso...
Db
Diagnosed with UC in Dec of 1999
PANCOLITIS-mild to moderate (remission for 2 years +!!??...i don't know...I am just SO happy when I have a good day!!)
3X400mg Asacol 3x per day
Mild flares a couple times a year
46 yrs old


Zippy123
Veteran Member


Date Joined Feb 2009
Total Posts : 735
   Posted 4/30/2009 11:33 AM (GMT -6)   
When I used to take Asacol I remember seeing them half broke open with a white streak in my poo.

fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 4/30/2009 11:36 AM (GMT -6)   
Yeah, but if it's getting out then what's the white stuff that's still in there? I should break open a capsule and see what the stuff in there looks like. Also, it's not like they're examning what we're pooping out, right? If he also says it's all getting out, maybe I'll take a picture!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).


Supa
Veteran Member


Date Joined Jul 2008
Total Posts : 748
   Posted 4/30/2009 12:14 PM (GMT -6)   
I see the shells in there most of the time. Like you, I didn't believe the GI when he told me it was just the shell. So I didn't fish one out, but when one was fairly seperate from the BM, I got a stick and poked at it. A small amount of white came out, but it was primarily just the shell. It definitely was not a significant amount left in the shell. So I feel like I am getting enough of the med.

However, I have a friend who has mild UC and she was taken off of Asacol because they weren't breaking down well enough, so I know it does happen.
Laura
 
33 years old, stay at home mom of 2 girls, ages 3.5 and 2.5
 
Diagnosed in 2007
Currently on:
Asacol 6pills/day
Biweekly injections for Humira clinical trial-going well so far!!
Canasa suppositories-1000mg nightly for recent flare


PSA
Regular Member


Date Joined Jan 2009
Total Posts : 498
   Posted 4/30/2009 12:19 PM (GMT -6)   
I used to have this problem with Asacol or Masacol. I was having hard tablets. They would float in the toilet - to be returned to chemist for recycling.
45 years Male Attorney
Diagnosed UC October 1989
 
Had two stage J Pouch Surgery Nov 2005; Take Down March 2006
Complications after surgery - Incisional Hernia and Ano Fistulas
 
"There are only two ways to live your life. One is as though nothing is a miracle. The other is as though everything is a miracle: Albert Einstein
 
"What you are aware of you are in control of; what you are not aware of is in control of you."
 


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 4/30/2009 12:22 PM (GMT -6)   
Saw, my pills are hard, too, but that's the outer coating, or "shell." It's specially made so it doesn't dissolve until it gets to your colon, so the coating is pretty tough as it survives the extreme acid in the stomach. Mine are a deep red color. I'm sure it's the same thing, as there's no generic type of Asacol, so only one manufacturer.

Supa, did your friend take an undissolved pill in to her GI, or did the GI just believe her?
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).


Supa
Veteran Member


Date Joined Jul 2008
Total Posts : 748
   Posted 4/30/2009 12:28 PM (GMT -6)   
Her doc believed her-said that wasn't uncommon and then just put her on something else-colozal I think. That worked for her too, just not quite as well as the Asacol. After I punctured my shell in the toilet, I told her about it and she was quite excited. She has just had 2 babies in 2 years, and her symptoms have been kept very well at bay. But she said she is glad to know that so that maybe she can try the Asacol again if her symptoms return.

I would take an undissolved pill to your doc if they aren't believing you!
Laura
 
33 years old, stay at home mom of 2 girls, ages 3.5 and 2.5
 
Diagnosed in 2007
Currently on:
Asacol 6pills/day
Biweekly injections for Humira clinical trial-going well so far!!
Canasa suppositories-1000mg nightly for recent flare


Peety
Veteran Member


Date Joined Mar 2008
Total Posts : 2855
   Posted 4/30/2009 12:36 PM (GMT -6)   
That's probably why asacol works best at keeping you well, not getting you out of a flare. When you are well and things aren't flying through, it has time to dissolve.
49 year old female attorney, diagnosed UC/pancolitis 1985, no surgery but much suffering. Asacol/5ASA 6x400 mg maintenance for 20+ years; use prednisone & Rowasa for flares. 
August 2008 sought care of naturopathic doctor. Food sensitivity test showed wheat/gluten, other intolerances; eliminated wheat/gluten from my diet. Probiotics (Ultimate Flora, 50 billion). 
Bad flare in March, seasonal? Back on prednisone 40mg, down to 10mg so far so good... Humira denied, started Remicade 4/12 and doing great~ 


notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16277
   Posted 4/30/2009 3:57 PM (GMT -6)   
I always seen unbroken pills in my stool. I am not sure if it's the shell or if it's a full pill but it looks like it's a pill. I've never probed at it or anything to see... I am curious.

Diagnosed with proctitis in March 2007 - Treated with Canasa 2x Daily
December 08 - Began treating with Asacol 400mg (9 a day)

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