Can Mesalazine (Asacol, Pentasa etc) cause Peptic Ulcers?

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LondonRed
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Date Joined Oct 2007
Total Posts : 1190
   Posted 5/3/2009 5:08 PM (GMT -6)   
Mesalazine may work differently but it is still an NSAID isn't it? Its non steroidal, its an anti-inflammatory too...
 
The Mesalazine may not disperse in your stomach but it can effect the lining and it also goes into the blood stream.
 
So can it cause inflammation, ulcers and other such side effects? I think it has caused recurrent Peptic Ulcers for me....

Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 800mg Asacol Tablets x 2 a day. VSL#3.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 5/4/2009 12:36 AM (GMT -6)   
I truly doubt it would be a cause.

Did your doc check you for h.pylori?

Have you been on pred?

Are you on any ppis? acid reducing meds?

quincy
*Heather* Status: mild flare enemas tapered to every 2nd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 5/4/2009 1:36 AM (GMT -6)   
Hi Q, yes I am on PPI's and they stopped the bleeding immediately and they did find HPylori too.... so I took the antibiotics. Last summer I had the same thing but without HPylori - maybe they missed the HP back then? It could just be the HP. The biopsies on both occasions ruled out IBD - yet my doc seems to thing it "may be" Crohns which has scared me.

My Haemoglobin want down to 9.2 and has now stabalised at 9.8 for the past 2 months. Life sucks.
 
The ulcers symptoms started after I started Asacol.


Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 800mg Asacol Tablets x 2 a day. VSL#3.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 5/4/2009 2:19 AM (GMT -6)   
Realistically...I can't see how Asacol would cause peptic ulcers....as well, you may have had them without even realising it.

Life sucks sometimes....and on a subjective level I can relate to that feeling.

Are you having any symptoms now? I see that men's levels should be 13 - 17 as per some research...is it assumed that the ulcers are the cause?

The suggestion of CD for you has come up previously....remember that the treatments are the same.

What's the doctor given you as other options regarding the peptic ulcers? Are they in the stomach or duodenum?

Are you on iron supplements?

Have you had your vitamin D and B12 levels checked out?

quincy
*Heather* Status: mild flare enemas tapered to every 2nd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 5/4/2009 4:24 AM (GMT -6)   
It is in the duodenum and I am currently without symptoms for anything. Maybe the PPI's are working?
I can accept CD in the colon given I have a small pathc of inflammation on the right hand side but the duodenum ulcer looks nothing like CD does and the biopsies came back negative TWICE in two different gastroscopies. I guess I am getting anxious and reading into his thoughts too much and self diagnosing again.

I am going on iron supplements on Wednesday which maybe I should have done at the start. Its just odd that the blood can go so easily but its hard to replace.

Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 800mg Asacol Tablets x 2 a day. VSL#3.


Christine1946
Veteran Member


Date Joined Aug 2008
Total Posts : 5963
   Posted 5/4/2009 11:59 AM (GMT -6)   
     Not sure about Asacol and/or Colazal causing ulcers but I do know for a fact prednisone can.  The doctor had me on Nexium while I was taking prednisone last year.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/08...now see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 5/4/2009 1:23 PM (GMT -6)   
Hi...definitely pred can cause them....changes the ph level in the upper gastro area and greatly increases acidity levels.

I know that stress changes the acidity level as well...and if you have ulcers, you could experience discomfort from that.

A ppi is the only way to prevent further erosion. And if you are completely h.pylori free, then you "may" have had it but don't any longer or there is another cause.

CD can be anywhere from mouth to anus and it's good the doc is keeping an eye on it, but your main goal is to keep it from getting worse.....so, that means keeping up on your meds and maybe not letting your mind take over..(hard to do, I know).

As well...the CD in your colon must still be kept at bay as best as possible, and if the Asacol is helping..why change. You're on an extremely low dosage of 1600mg daily.
You can increase if needed, which is a good thing.

Have you had your vitamin D and B12 levels checked?
quincy
*Heather* Status: mild flare enemas tapered to every 2nd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls, Natural Factors Ultimate). @ bedtime
~various digestive enzymes as needed; started Omega 3 
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 5/4/2009 2:38 PM (GMT -6)   
I am going to start Vitamin D again soon I think... need to get over all the meds for the Ulcer, Going to start Iron and Vitamin C together for 6 weeks.

Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 800mg Asacol Tablets x 2 a day. VSL#3.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 5/5/2009 12:40 AM (GMT -6)   
Keep us posted as to how you're feeling.

Yeah, hard to do the acceptance thing sometimes...but I think meds for UC or CD or ulcers or whatever...if you need them, you need them.

Some meds like prednisone..at least we can control it sometimes if there are other meds available to use....and I like that route a lot better.

How often do you get your blood checked?

Again....did you ever have the vitamin D or B12 levels checked?

quincy
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1190
   Posted 5/5/2009 1:49 AM (GMT -6)   
No never had vit b12 or checked, where would I do that? doctors don't do that do they?

Diagnosis Oct 07: Mild Crohn's Colitis. Also suffer from bleeding Peptic Ulcers. By the grace of God currently in remission. Current Medication: 800mg Asacol Tablets x 2 a day. VSL#3.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 5/5/2009 1:18 PM (GMT -6)   
Hi...yes they do, and I would assume since your blood levels are so low that yours would have been checked. Get it checked as well as your vitamin D.
I'm serious in my suggestion....so please don't pass on it.

quincy
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 

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