Commensal bacteria can enter colonic epithelial cells.

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Old Mike
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Date Joined Jan 2007
Total Posts : 3886
   Posted 5/4/2009 8:08 AM (GMT -6)   
Interesting abstract, might even explain why antibiotics don't produce a cure for UC, the bacteria have invaded colon cells and
are protected.
Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis.
Old Mike

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Date Joined May 2005
Total Posts : 495
   Posted 5/4/2009 11:29 AM (GMT -6)   

Mike your posts are always relative and pertinent, thanks.

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Date Joined Feb 2009
Total Posts : 735
   Posted 5/4/2009 11:41 AM (GMT -6)   
Interesting. thanks Old Mike.

Old Mike
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Date Joined Jan 2007
Total Posts : 3886
   Posted 5/4/2009 2:36 PM (GMT -6)   

Thanks folks:

Would like to add that I tend to believe that if the hydrophobic mucus barrier is intact and functional then the bacteria cannot

penetrate and infect the colon cells.

I check pubmed at least once a week for new and interesting research on UC. I have been waiting for 29 years for them to

come up with a medical as opposed to surgical cure, still waiting.

Old  Mike


Veteran Member

Date Joined Feb 2009
Total Posts : 1916
   Posted 5/4/2009 10:09 PM (GMT -6)   
Good article. Right before I was diagnosed, I was seeing a homeopathic physician. I got her to test me for intestinal bacteria. The test came back negative for any lactobacillus bacteria, the beneficial probiotics. Perhaps this started my problem. It sure would be great if they could cure this darn disease. There is too much suffering and too few answers for us. I think a lot of GI docs give up on us when things aren't working just when we need their support. As always, I am grateful for this forum.
diagnosed 1/09 with colitis,54 yo, colazal, fish oil, synthroid, cymbalta

Old Hat
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Date Joined Feb 2007
Total Posts : 5190
   Posted 5/5/2009 10:27 PM (GMT -6)   
Thanks a lot for posting this link, Old Mike. Maybe this explains why some UCers get relief from Xifaxin, a non-systemic antibiotic that originated in Europe as a treatment for travellers' diarrhea. It's still fairly new to U.S. gastro practice. / Old Hat (30 yrs with left-sided UC ... [etc.])
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