Bewdy-- my UC gets much worse with any 5ASA drugs- oral or rectal. My GI's have acted skeptical towards my claim that the rectal could make me worse too, as they say that topically no way should it cause trouble. But I know what I feel- a burning and very uncomfy feeling unlike that from other (eg streroid) enemas, and for me this means that all the 5ASA's are causing some sort of allergic reaction. Hopefully this is not the case for you, but I just wanted to pass it on.
Pancolitis >20 years, allergic to all 5ASAs
Tried everything under the sun (natural and alternative)
Some partial success with TSO but was too expensive to keep up
Remicade Humira, lots of probiotics, entocort, tapering pred again, maybe surgery this year