Mesalazine Enema - Just cant seem to handle it.

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New Member

Date Joined May 2006
Total Posts : 8
   Posted 5/18/2009 9:41 AM (GMT -6)   
My doc has put me back on Mesalazine Foam Enemas again for my UC, until I try a new course of cyclosporine enema drugs in a couple of weeks.

I was very reluctant to take the mesalazine again as everytime I've found it really hard to take and this time seems no different. With predfoam I'm fine, and more recently I've been using the colifoam which is messy to get in the dispenser, but again easy enough to hold in once it's adminstered, but I just can't seem to take this mesalazine and keep it in for long.

i find the nozzle so uncomfortable to insert and as soon as I inject it I just can't seem to tolerate the urge to get it out of my system as soon as possible, and even on the rare occasions I've managed to hold it in for ten minutes or so, even then I find myself leggin it to the loo to get rid of it.

The whole sensation of it feels like it is burning, and the sheer volume of it seems just to much for me to take. I'm also really concerned that if I can't keep it in, that it is not actually having much of a positive effect by account of the drug not actually getting into my system properly.

Does anyone else find this the problem with mesalazine? My symptoms have been so bad recently, I really wonder about pursuing the use of a med which I find is making feel worse rather than better, it always seems the same with mesalazine for me.

Regular Member

Date Joined Jan 2009
Total Posts : 498
   Posted 5/18/2009 10:25 AM (GMT -6)   
Hi Bewdy

Do you apply some ointment/gel in your butt before inserting the nozzle. Please keep a pillow under your bum/leg before injecting. Please take a deep breath inside so that you don't feel the urge to poo. I had used mesalzine at some point of time. I could retain it for quite some time. Infact, at times I could retain it for more than six hours. Please check your posture to ensure that the drug gets into the colon. Did your doctor suggest cortifoam.
45 years Male Attorney
Diagnosed UC October 1989
Had two stage J Pouch Surgery Nov 2005; Take Down March 2006
Complications after surgery - Incisional Hernia and Ano Fistulas
"There are only two ways to live your life. One is as though nothing is a miracle. The other is as though everything is a miracle: Albert Einstein
"What you are aware of you are in control of; what you are not aware of is in control of you."

Veteran Member

Date Joined May 2008
Total Posts : 574
   Posted 5/18/2009 12:26 PM (GMT -6)   
Hi i have used mesalazine foam with little joy like you found it very hard to keep in( but was fine with the predfoam )used it for about 3 weeks then gave up as i thought it could not be doing anything as it was not in my body long enough hpoe you find a way good luck
  Diagnosed 22.5.08 with Lft sided U/C
  Meds Predfoam 20mg 2x day stopped started pentasa supps 1gm 26/6/08
 Asacol 800mg x2 twice daily
  Domperidone 10mg as needed
  co codamol 30/500 x2 when needed
  Asacol foam 2g nightly 19/3/09
  Prednisone 60mg 19/3/09 tappering after2wks

Tommy S
New Member

Date Joined Feb 2009
Total Posts : 12
   Posted 5/18/2009 2:41 PM (GMT -6)   
I've been taking this Mesalazine enema for around 6 months now, and I can't keep it in for that long either but it must be doing something? & on the subject of the nozzle - it is such a rubbish design. But just keep doing it nonetheless matey.

Veteran Member

Date Joined Mar 2007
Total Posts : 2832
   Posted 5/18/2009 10:23 PM (GMT -6)   
Bewdy-- my UC gets much worse with any 5ASA drugs- oral or rectal. My GI's have acted skeptical towards my claim that the rectal could make me worse too, as they say that topically no way should it cause trouble. But I know what I feel- a burning and very uncomfy feeling unlike that from other (eg streroid) enemas, and for me this means that all the 5ASA's are causing some sort of allergic reaction. Hopefully this is not the case for you, but I just wanted to pass it on.
Pancolitis >20 years, allergic to all 5ASAs
Tried everything under the sun (natural and alternative)
Some partial success with TSO but was too expensive to keep up 
Remicade Humira, lots of probiotics, entocort, tapering pred again, maybe surgery this year

New Member

Date Joined May 2006
Total Posts : 8
   Posted 5/19/2009 2:18 AM (GMT -6)   
Yes burning sensation is how I would describe the feeling too. I find that trying to hold the foam enema in not unlike wrestling with a mega attack of the runs, and then passing the said enema is not unlike the day after a very hot curry. To me this just feels wrong but it's only day three so I'll persist for a couple more days, but if there's no improvement then I'll get back to my doc. Thanks for the replies.

New Member

Date Joined May 2009
Total Posts : 2
   Posted 5/19/2009 7:26 AM (GMT -6)   

I am on Salofalk liquid enema, 4g 60 ml for the past 2 months. It contains mesalazine and have never felt a burning sensation.

Do you know why your doctor prescribed foam over liquid enema?
Are you having a flare up? - because in a flare up there may be a burning sensation because the bowel is inflammed.

Take care,

New Member

Date Joined May 2006
Total Posts : 8
   Posted 5/19/2009 7:32 AM (GMT -6)   
My doc prescribed the foam over the liquid, as I'm even worse with a liquid enema, I can literally only hold it for about 10-20 secs then whoosh, I'm off to the lav.

Yes, I'm about 6 months into a lfare up at the moment, and have been through a lot of differnent meds now, prefoams/collifoam/prednisolone tablets, just finishing my 3rd course of them, and now asathiaprine which is taking a few weeks to kick in.

New Member

Date Joined May 2006
Total Posts : 8
   Posted 5/19/2009 9:29 AM (GMT -6)   
Something which has just occured to me, i think two of the reasons I am struggling with the enema, is a combination of the applicator being uncomfortable and making my bowel hypersensitive before I've even adminstered the drug, and also the sheer volume of the enema itself as it expands inside me.

Something I really preferred about the collifoam enema was the fact that I could syringe it in myself and do it in a more gradual way, has anyone tried using their own bum syringes as opposed to directly using the supplied messalzine applicator? I'd try the collifoam syringe, but the syringe size is tiny compared to the amount that comes out of the mesalazine spray.
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