Oh, yes, wish I didn't! I had same reactions to all mesalamines - rectal and oral! Try the low dose steroid rectal meds.
Senior - New diagnosed with proctosigmoiditis - 6/2008 Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred. No mesalamines!!
Started on prednisone Feb.7, 2009 - tapering to 20 mg. - upped prenisone to 25mg. on my own (bleeding returned) - 6MP - 50 mg. 2/28/2009
Now 75mg. and 15mg. prednisone for a week.
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.