Newbie - Mesalamines haven't worked...what else?

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Christiana1
New Member


Date Joined May 2009
Total Posts : 1
   Posted 5/18/2009 3:27 PM (GMT -6)   

Hello everyone,

 

I am new to this forum.  I am looking for answers.  I was diagnosed a little over a year ago with UC.  I have been hospitalized once and treated intravenously with Prednisone.  I was severely dehydrated and malnourished.  I am Celiac as well.  I have been on 5 different brands of mesalamine; Asacole, Canasa (suppository), Lialda and Penasa.  All they seem to do is make my hair fall out.  They don't help me, only the Prednisone seems to help.  Once I am weaned off Prednisone, I fall right back into a flare up.  I just can't live on high doses of Prednisone my whole life.  Help me!


fruitgirl
Veteran Member


Date Joined Feb 2009
Total Posts : 7150
   Posted 5/18/2009 3:32 PM (GMT -6)   
Hi, welcome, and sorry that you're here! I'd recommend that you go to the Chron's and Colitis Foundation of America website (ccfa.org) and read their info about medicines. They have a lot of great, complete info on the different classes of medications.

There are other 5ASA drugs you could try (depending on where your UC is located), such as Colazol. It's related to mesalamine and I'm not sure how it is different. You could also try the "old-school" sulfalzine.

The usual "next step" are immunomodulators like 6MP and Imuran.

Then there is Remicade, a biologic drug.

I hope you find some relief soon! Definitely get in to see your doc and find something to help you get off the pred!
Symptoms began in November 2008, ~4 weeks after giving birth to my son.
Eased for ~3 weeks in December, possibly b/c of probiotic use?
Returned in January 2009 (with a vengeance), diagnosed with pancolitis on January 30.
Currently taking Asacol (400mg 4 pills 3x daily), Rowasa nightly, Culturelle probiotic, and Zoloft (25 mg).


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 5/18/2009 7:02 PM (GMT -6)   
The mesalamines can work better sometimes in conjunction with something else. There was study by some big drs at Mount Sinai in NYC (I'm pretty sure) that showed that the oral mesalamine in conjunction with rectal meds were way more effective.

I know you said you tried Canasa suppositories. HAve you tried any other rectal meds? The ones with steroids are good to try as a step before going back to Prednisone. The dose of steroids that's absorbed by the body is a lot less.

I would definitley check out that link to the CCFA website. They have a good section about different medicines.

It takes a while to find what will work for you. Hang in and I'm sure you'll get a lot of good advice from this board.
-------
UC for the last ten years
Current Meds: 6MP since 2006, Lialda, Asacol foam, Lomotil
Past Meds: You name it; I've tried it. (Asacol, Colazol, Pentasa, DiPentum, Rowasa, Canasa, Cortenema, sulfasalazine, Cortifoam)
Alternative treatments I have had success with: Acupuncture, Hypnotherapy


jeanneac
Veteran Member


Date Joined Feb 2009
Total Posts : 1914
   Posted 5/18/2009 9:21 PM (GMT -6)   
Wow, celiac and UC. Which one started first? Have you seen a dietician so that you know what to eat? You will get good advice here. Do find a doctor you trust and will listen to you though. That is a must. Good luck to you.
diagnosed 1/09 with colitis & diverticulitis
 54 yo, colazal, fish oil, synthroid, cymbalta


Yavw
Regular Member


Date Joined Feb 2009
Total Posts : 29
   Posted 5/18/2009 9:58 PM (GMT -6)   
I was diagnosed around 6 months ago, so I'm fairly new to the disease also. But I've found that probiotics help a lot to reduce the symptoms, if you find the right one. I first tried primal defense which did nothing, but all the other one's I've used at least help. I'm only using probiotics right now, asacol didn't do much for me either. And prednisone works, but I don't like the idea of using it long term. And probiotics may work for one person, and not another, so try different kinds if it doesn't work at first. I have noticed that probiotics that have lactobacillus acidophilus, and bifidobacteria infantis work pretty well for me. I am using align, which has a certain kind of bifidobacteria infantis, and just generic walgreens brand probiotics that has lactobacillus acidophilus and a bifidobacteria strain, it has 20 billion strains per capsule. I have also found the the one's that have high amounts of strains per capsule work better. Like I said, try different kinds out to see what may or may not work, and you may find one that gets the job done.

Dr-A
Veteran Member


Date Joined Jul 2006
Total Posts : 2105
   Posted 5/19/2009 10:13 AM (GMT -6)   
Could go old school with the sulfa drugs, add rectal meds, immune modulators are also a step forward. Biologics are another step, remi, humira. Where's the disease at?
Proctitis DX 1999, Pancolitis DX 2008
Immuran
Golimumab study (100mg every 4 weeks)
L-Glutamine 5000 mg + 600 mg pyridoxal alpha-ketoglutarate
Probiotis/VitD3+Ca/1000mg DHA

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