How long for SALOFALK increase to kick in?

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UniG
Regular Member


Date Joined May 2009
Total Posts : 110
   Posted 5/21/2009 8:26 PM (GMT -6)   
My dose of Salofalk has been increased - slightly. It's been a week and I don't see a difference? Any opinion as to how long I should wait before deciding if it's working or not?

thanks,
Uni-g :
40 yr. female
Diagnosed Jan 2008 ulcerative proctitis 9" of lower colon.
Last sigmoidoscopy Jan 2009, 17" inflammation of lower colon.
Naturals: probiotics, ground flax, salmon oil, Glutagenics, Aloe Vera juice, mega vitamin supplements, Curcumin and a Vegan diet.
Pharma: Salofalk enema and oral
My brother had UC and ended up with an illiostomy after years of struggle.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30585
   Posted 5/21/2009 11:50 PM (GMT -6)   
Hi..increased from what to what? How long were you on the first dosage?

Are you taking the enemas nightly?

What are your symptoms at this time?

Patience......definitely needed with 5ASA meds.

q
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


UniG
Regular Member


Date Joined May 2009
Total Posts : 110
   Posted 5/22/2009 10:14 AM (GMT -6)   
Hi Quincy -
The bum doc upped my Salofalk dose to 1500mg oral, a day plus enema every night. I'm sort of limpin' along. The bleeding seems to have stopped but regular bms have not resumed. Constipation is the problem, despite a super healthy, vegan, high fibre, etc.,etc diet.

I appreciate your experience with 5ASA. I wasn't sure if they were a quick fix or a patience kinda thing.

Uni-g
40 yrs.
Diagnosed Jan 2008 ulcerative proctitis 9" of lower colon.
Last sigmoidoscopy Jan 2009, 17" inflammation of lower colon.
Naturals: probiotics, ground flax, salmon oil, Glutagenics, Aloe Vera juice, mega vitamin supplements, Curcumin and a Vegan diet.
Pharma: Salofalk enema and oral
My brother had UC and ended up with an illiostomy after years of struggle.


ozziek
Regular Member


Date Joined Jan 2009
Total Posts : 20
   Posted 5/22/2009 11:36 AM (GMT -6)   
Hey There!

I was on 3000mg of salofalk daily and when my GI upped it to 4500mg I didnt really notice a big difference at all. I know this isnt much help.... but I just thought Id pitch in that I didnt see a difference at all. It was my other meds that helped me to make some improvements!

21 yrs old.
diagnosed April 2008 - have been in an active flare since. 
Prednisone - daily maintenance dose of 20mg. (4pills)
Salofalk - 4500mg daily (9pills).
Iron - 900mg daily (3 pills).
Calcium - 1000mg daily (2pills).
Multivitamin.
Allergic to Imuran and Sulfa drugs.
Have had 3 Remicade infusions.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30585
   Posted 5/22/2009 12:45 PM (GMT -6)   
Hi UniG..you have to realise that the concept of using medications, especially 5ASA is for treatment and then for maintenance. If you can use it, that's a good thing, for it can serve you well for a very long time.

I look back 20 years....grateful for my doc and his belief in the meds. The patience part was OK since I didn't know any better, but it took a lot of reassurance from him.

The fact that you're seeing improvement is a good thing. Take that and allow the meds to do their thing. A colon doesn't heal in a relatively short time...but it can do so slowly but progressively.

Consistency in the meds is important but I still don't think you're on quite enough oral Salofalk. That can be increased as you need....but do keep with the enemas for at least 3 weeks to a month.

They must also be tapered to every second night once you feel better...but if you've tapered too fast, you'll know soon enough.

You won't be able to hurry it....however....a humbling realisation, not to become desperate if you've not done the effort to actually see how they can work.

I'm sure this isn't really a colsolation, but I was once on the enemas for 4 months nightly....and had to increase the Asacol to 3200 mg daily. So, you see, it's a flexible medication. finding out what it can do for YOU is what you have to do.

Remember, the goal is for long-term, and not to believe it's an all or nothing concept.

5ASA meds are also believed to help in preventing colon cancer....a bit of an insurance from my perspective...especially for me since I also have UC-related liver disease which increases the % of cancer over and above having UC over so many years. But, keeping the inflammation down is the key.....I can't be the only one who's been on it for this long, and if I am, I question either my stupidity or optiomism.

Hang tough in using the meds....please be patient.

quincy


*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


UniG
Regular Member


Date Joined May 2009
Total Posts : 110
   Posted 5/22/2009 12:56 PM (GMT -6)   
Hey q- you're super, thanks.

I think my doc is approaching meds from a minimalist perspective and of course I am thankful. He's increased Salofalk incrementally only. I'll stay on this current dose for a good while longer and see what happens. I'm pretty sure the bleeding has pretty well stopped... i think, - time will tell.

I'm going to this forum about Glutagenics when I get time. I take the product twice a day or more if I'm really gassy. It stops the gas like snuffing a candle - a very good product. It is used to heal the intestinal lining. Here's a link, fyi.

http://www.metagenics.com/products/detail.asp?pid=95
40 yrs.
Diagnosed Jan 2008 ulcerative proctitis 9" of lower colon.
Last sigmoidoscopy Jan 2009, 17" inflammation of lower colon.
Naturals: probiotics, ground flax, salmon oil, Glutagenics, Aloe Vera juice, mega vitamin supplements, Curcumin and a Vegan diet.
Pharma: Salofalk enema and oral
My brother had UC and ended up with an illiostomy after years of struggle.


notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 16277
   Posted 5/22/2009 1:01 PM (GMT -6)   
1500mg a day is not a lot. I was taking 1200mg 3 times a day and am currently reducing down to 800mg 3x a day. I am not flaring and I am taking more than you... I also use Canasa suppositories at night to help heal the mild inflammation in my rectum. When I started taking Asacol, it took a while for my symptom to go away. I first noticed the blood going away, then going less often, then the D stopped but things were still soft, now things have finally firmed up and I feel like I am somewhat healed. Don't give up. I think if you have seen some improvements, maybe you will see more. You can always inrease your dose of Salofalk if you need to. Hope you feel better soon.
Diagnosed with mild proctitis in March 2007: Treated with Canasa (as needed)
December 08: Began treating with Asacol 400mg (9/day) + Canasa 2x/day - Anemic
May 09: Off Canasa, taking Asacol (9/day)
Back on Canasa every other night + Asacol (9/day) + Probiotics + Iron
Reducing to 6 Asacol/day + Canasa at night + Probiotics + Iron - So far so good!!!
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30585
   Posted 5/22/2009 1:29 PM (GMT -6)   
UniG...I'll check out the link. Thanks.

My doc believes slower is better...at least one can increase. He started me on 4 Asacol (1600mg) daily and then increased it to 6 after a while, that in conjunction with the enemas once I was diagnosed via c-scope.

I dread the day he retires...

q
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 

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