poll: should i go on 6mp or not?

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Regular Member

Date Joined Apr 2009
Total Posts : 178
   Posted 5/23/2009 6:47 PM (GMT -6)   
i have been in flare for 2-3 mos.  pred 40 mg and tapering down to 20 and off in about 3 weeks.  I am planning a fast after this time....if i cannot achieve remission, should i try 6 mp.....i am not flaring terribly.....a few bms a day with d and blood sometimes....sometimes a little formed stool.....not a lot of pain.....urgency is not too big a problem unless i just try to hold it too long....mornings are the worst with some pain during bm and a little rectal discomfort for a while after eased by soak in tub...probably hemmeroids......what do you all think.....will i be able to get in remissions again without immuno drugs.....should i just deal with what little symptoms i am having if i can.....should i be using rectal meds....rowasa did not really seem to be helping....i think my doc will let me try whatever i push him to do...he knows i don't wanna go on 6mp, so he is giving me space....i wonder if steroid ememas would work better than rowasa....????

Veteran Member

Date Joined Jun 2008
Total Posts : 2865
   Posted 5/23/2009 8:22 PM (GMT -6)   

Sure wish I had the answers for you.  I could not tolerate mesalamines so I ended up on steroids and now down to 10 mg. tapering.  I have been on 6 MP for three months - not sure if it is working or not.  I seem about where you are - mostly formed BM's - 2 or maybe 3 each morning - not much cramping or pain but my doctor's concern is with the blood and mucous each day.  When on 30 mg. down to two weeks on 20 - no blood and little mucous - much better. 

Anyway, that was my decision because I wanted to get off prednisone as fast as possible - now on 10 mg.  My doctor has referred me to a world renown (so my doctor, etc. says) specialist at Albany Medical Center June 18.  I am to stay on 10 mg. prednisone and 75 mg. 6 MP until then.  He also told me to take Imodium as needed and pepto bismal for nausea. 

Good luck with what you decide.  So far side effects of 6 MP are thinning hair and nausea/sweating/headaches (some could be from tapering).  Not really too bad! 

By the way, I could not tolerate Rowasa and tried Proctofoam and steroid suppositories - all seemed to make bleeding and discomfort in rectum area worse.   Hydrocortisone enemas work for most but I cannot administer them properly because of arthritis and my obesity.  Worth trying!


Senior - New diagnosed with proctosigmoiditis - 6/2008   Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred. No mesalamines!!
Started on prednisone Feb.7, 2009 - tapering to 20 mg. - upped prenisone to 25mg. on my own (bleeding returned) - 6MP - 50 mg. 2/28/2009 
Now 75mg. and 15mg. prednisone for a week. 
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.

UC Mom
Regular Member

Date Joined Jun 2007
Total Posts : 146
   Posted 5/23/2009 8:31 PM (GMT -6)   
I have posted this many times before. 6 mp is my son's miracle drug. Just went to the gastro on Thursday, and he doesn't need to go back for a year. He will continue bloodwork every 3 months. Best of luck to you.
UC Mom
Son diagnosed 10, 2006 at age 15
6MP 75 mg. per day

Veteran Member

Date Joined Dec 2008
Total Posts : 3231
   Posted 5/23/2009 8:46 PM (GMT -6)   
Hi lucasJ,

Have you tried alternative treatments? Fecal transplantation, probiotics, eating anti-inflammatory foods, taking anti-inflammatory supplements, avoiding pro-inflammatory foods?
Joy - 47 yrs and counting
Colitis Dec 06 (also have IBS)
Currently in remission
Don't expect your doctor to cure your health problems. Your health is your responsibility.

Lexapro (for stress), Probiotics and Vitamins (a whole bunch of them)
Avoid HFCS, foods high in fructose, artificial sweeteners
When flaring: eat anti-inflammatory foods, avoid pro-inflammatory foods
Previous treatments: Fecal transplantation (worked), Prednisone (stopped working), Colazal (stopped working), Asacol (stopped working)

Mommy pooh
Regular Member

Date Joined Apr 2008
Total Posts : 131
   Posted 5/23/2009 9:43 PM (GMT -6)   
The steriod enemas (hydrocortisone) I just started have shown wonderful results! After doing them 2 days I have NO pain and NO blood. 6MP got me into remission after a long flare and kept me quiet just over a year. I started having minor symptoms a few weeks ago that were getting worse and the steroid enemas seem to be knocking it out.
  • 26 years old, married, Stay-at-home Mommy to 2 year old daughter 
  • Ulcerative Colitis since Sept. 2004
    • 1st flare Sept-Nov 2004
    • 2nd flare Aug. 2007-July 08 
  • Currently taking:75mg 6MP, 4 Lialda, Loestrin 24, Allergy meds., Digestive Advantage Sustenex, Maxalt when I get a migraine, Zanaflex to prevent migraines, and allergy shots once a month 
  • 10/6/08 Found a 1cm kidney stone in right kidney.  Had the stone blasted and passed the fragments.


Veteran Member

Date Joined Mar 2008
Total Posts : 1202
   Posted 5/24/2009 9:01 AM (GMT -6)   
6mp didn't do the trick for us, but it is hard to tell when you take it while flaring. My daughter is still on it, in case the Remicade fails, it is a back up. It takes months to get into your system at a therapeutic level. There were only minor side affects--temp. hair loss, otherwise nothing. It is hard to judge if you can deal with your symptoms as they are now. At least there are still options for you. You should probably have the blood work done, as that takes a couple of weeks to get back, and have your kidney function tested, then if you go on it and give it the time it needs to work, you will know how it does for you by the end of the summer. If no better, you can try something else, and if better, it probably will be your drug of choice.
I'd try the Cortafoam first...it also works nicely with ltd. side affects. My 2 cents.
Daughter,15 diagnosed 1-08 w/ UC .
Previous drug sampling: Asacol, Prevacid, Flagyl, Prednisone- 50mg to 0, 4 major flares '08.Hospital four x. Low residue diet,
6MP, Colazal , Cortifoam enemas,
Trying probiotics, Niferex, fish oil, Magnesium, Acupuncture.
Remicade 10mg per kilo@ 8wks, since 10-08. Still on 6mp and Colazal

Regular Member

Date Joined Apr 2008
Total Posts : 460
   Posted 5/24/2009 10:31 AM (GMT -6)   
I would give the steroid enemas a try.  They always help me within a few days.  Keep in mind that 6MP takes about 3 months to work so if you're going to try it, the sooner the better.  It may be just what you need to get you over the hump and into complete remission.  I have no side effects from it and tolerate it great.  I'm not 100% but I'm way better than I was before taking it.

Female, Age 38
Diagnosed w/c.diff 7/02 when pregnant w/1st and only child during 2nd trimester(wasn't on antibiotics)
C.diff flare within weeks of delivering baby 1/03, Diagnosed with UC 2/03
Current Meds:
Lialda, 6MP
Ferrex Forte
Acidophillus, Sacchromyces Boulardii, Oil of Oregano

Regular Member

Date Joined Jan 2009
Total Posts : 307
   Posted 5/25/2009 8:17 AM (GMT -6)   
I just started 6mp about 3 weeks ago to avoid remicade.  I'm praying every single day that it kicks in and works for me because I need something at this point.  I'm currenly in a pretty bad flare so I started 30mg of Pred last wednesday. 
I would definitly try the 6mp, the side affects arent that bad at all minus the fatigue which is bareable.  The only thing that stinks about the drug is the fact that it takes 3+ months to kick in, if at all...
Good luck!
Age: 25 / Male / Florida
Diagnosed: 11/08 / Pancolitis
Asacol - 2 x 3 day (waiting for results)
6MP - 50mg - started 5/04/09
Prednisone / ended 1/09 (started at 30mgs and tapered down)
Mens Multi Vitamin - 1 a day
Calcium & Vitamin D3 - 1200mc of Calcium and 800iu of Vitamin D3  
Jaro - Dophilus Probiotic (3.4 Billion) - 1 a day
Diagnosed with PSC: 3/9 --now taking Urso
Sunflower Seed & Spinach Diet - Started 4/26/09

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