Why no 5ASA Foams?

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bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/24/2009 3:20 PM (GMT -6)   
The foam based rectal meds are so much easier to use/less messy. Curious why no foam based Rowasa?
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3-4X per week
Curcummin and Probiotics/Rueteri.
Bowel Soother and IntestiNew, Fish Oil, Calcium/Mag/Zinc, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Could never tolerate artificial sweetners
I try to excersice/swim daily
Did I happen to mention I HATE this disease!!!
 
*Recent Changes In Blue*


kops2da
Veteran Member


Date Joined Jun 2008
Total Posts : 2865
   Posted 5/24/2009 6:09 PM (GMT -6)   

I believe there are some out there.  Someone will answer you - I think maybe Salofalk or something like that is one.

ElaineNY


 
Senior - New diagnosed with proctosigmoiditis - 6/2008   Tried, Colozal, steroid enemas, etc. - started working but severe side effects occurred. No mesalamines!!
Started on prednisone Feb.7, 2009 - tapering to 20 mg. - upped prenisone to 25mg. on my own (bleeding returned) - 6MP - 50 mg. 2/28/2009 
Now 75mg. and 15mg. prednisone for a week. 
Probiotic Align, Prilosec for GERD, Gas-X, vitamins, Calcium/D
Tylenol for knees and arthritis.
 
 
 


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/25/2009 3:42 PM (GMT -6)   
I just found this after googling mesalamine foam...I'm not sure this stuff is available here in the US yet, but if anyone is currently using it please chime in.


Clinical

Mesalamine foam can replace liquid mesalamine enemas for ulcerative colitis
Last Updated: 2009-01-06 17:50:47 -0400 (Reuters Health)

NEW YORK (Reuters Health) - In patients with proctitis and proctosigmoiditis, a mesalamine foam can be substituted for difficult-to-retain mesalamine liquid in therapeutic enemas.

In the December issue of the American Journal of Gastroenterology, an international team led by Dr. Antoine Cortot at Hopital Claude Huriez in Lille, France, points out that because mesalamine induces remission in ulcerative colitis, a placebo-controlled trial would have been unethical.

The researchers therefore conducted a noninferiority study, in which 375 patients were randomized to treatment with either mesalamine foam, 1 g/80 mL/d, or mesalamine liquid enema, 1 g/100 mL/d for 4 weeks. All patients had mild-to-moderate ulcerative colitis and disease extending at least 5 cm from the anorectal junction but not beyond the splenic flexure.

"Remission rates...in foam versus liquid were 68.3% versus 73.6% in per protocol population...and 66.7% versus 70.5% in intention-to-treat population," the researchers report. Both treatments were well tolerated, they add.

"Although the noninferiority of mesalamine foam could not be strictly demonstrated at week 4 in the per protocol analysis, it was achieved in the intention-to-treat population," the investigators write.

They add that because the trial had enrolled mostly proctitis and proctosigmoiditis patients, their results mainly concern these two forms of ulcerative colitis and it was not possible to reach conclusion for left-sided ulcerative colitis.

Nevertheless, they conclude, "Mesalamine foam enema represents a clinically efficient and well-tolerated therapeutic alternative to mesalamine liquid enemas in patients with mild-to-moderate active proctitis and proctosigmoiditis. It may be especially appropriate in case of poor tolerance of enemas because of acute rectal inflammation."

Am J Gastroenterol 2008;103:3106-3114.
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3-4X per week
Curcummin and Probiotics/Rueteri.
Bowel Soother and IntestiNew, Fish Oil, Calcium/Mag/Zinc, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Could never tolerate artificial sweetners
I try to excersice/swim daily
Did I happen to mention I HATE this disease!!!
 
*Recent Changes In Blue*


JoMarie
Regular Member


Date Joined Dec 2008
Total Posts : 55
   Posted 5/25/2009 6:01 PM (GMT -6)   
It is available in Europe---not in the US or Canada...Has been available there for at least 9 years.  Still nothing here.  It is disappointing.  My 14 year old son could greatly benefit from it.

bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/25/2009 9:26 PM (GMT -6)   
Sometimes this country just sux : (
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3-4X per week
Curcummin and Probiotics/Rueteri.
Bowel Soother and IntestiNew, Fish Oil, Calcium/Mag/Zinc, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Could never tolerate artificial sweetners
I try to excersice/swim daily
Did I happen to mention I HATE this disease!!!
 
*Recent Changes In Blue*


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5189
   Posted 5/27/2009 11:02 AM (GMT -6)   
You can try contacting Shire Pharma about it-- their HQ is in Wayne, PA. Their affiliate markets it in Australia! One of their reps happened to be at my gastro's office during a recent appointment-- so I stopped him on his way out to ask about getting the foam in N. America. He promised to bring it up to his bosses. / Old Hat (30 yrs with left-sided UC ... [etc.])

JoMarie
Regular Member


Date Joined Dec 2008
Total Posts : 55
   Posted 5/27/2009 11:59 AM (GMT -6)   
Thanks, Old Hat...I just got onto the Shire Pharma website, selected the United States group, and sent an email.  Maybe if enough of us do the same, they will take note and realize that there is a market for this. 
 
Jo

bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/27/2009 5:39 PM (GMT -6)   
I also sent an email to the Rowasa folks and never received a reply...
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3-4X per week
Curcummin and Probiotics/Rueteri.
Bowel Soother and IntestiNew, Fish Oil, Calcium/Mag/Zinc, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Could never tolerate artificial sweetners
I try to excersice/swim daily
Did I happen to mention I HATE this disease!!!
 
*Recent Changes In Blue*


quincy
Elite Member


Date Joined May 2003
Total Posts : 30976
   Posted 5/27/2009 7:17 PM (GMT -6)   
Asacol makes a foam in Britain....maybe you could email them and enquire if it'll be made in N. America?

q
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/27/2009 8:46 PM (GMT -6)   
Hey Q. It's possibly a matter of the company getting the foam FDA approved or they would have already marketed here.
Moderate Pancolitis
Dx'd 05/2007
8 Pentasa per day (4/2)
Corti Foam p.m. 3-4X per week
Curcummin and Probiotics/Rueteri.
Bowel Soother and IntestiNew, Fish Oil, Calcium/Mag/Zinc, Multi Vitamin and Melatonin
Eliminated Fructose and Corn Syrup
Could never tolerate artificial sweetners
I try to excersice/swim daily
Did I happen to mention I HATE this disease!!!
 
*Recent Changes In Blue*


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5189
   Posted 5/27/2009 10:06 PM (GMT -6)   
I think that the mesalamine foam is manufactured by Falk in Germany-- then it is distributed thru other pharmas in the UK, Europe, & Australia. Last yr when I did some searching on the Web, I found out that the distributor in Australia is an affiliate of Shire. Julee70 actually bought a supply of the foam while traveling abroad last fall-- so she may be able to confirm the manufacturer from the labels she has on her packages. I think Knitty_Cat had mentioned that it's called "Colifoam" in Australia. To bbc, you won't hear about foam from the Rowasa manufacturer-- it's a different pipeline. In fact, Rowasa was sold by one pharma to another in the U.S. a couple yrs ago. We did a thread on it after some members reported having their supply temporarily cut off at regional pharma warehouses! / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])

quincy
Elite Member


Date Joined May 2003
Total Posts : 30976
   Posted 5/27/2009 10:24 PM (GMT -6)   
ah interesting.....maybe worth another email to them?
I agree that the foams are much easier to retain....but much less med per dosage.

q
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance 
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux);  Effexor XR 75mg(depression);  Pulmicort/Airomir (asthma) 
~vitamins/minerals/supplementsProbiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!
 


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 5/28/2009 12:01 AM (GMT -6)   
I bought the Asacol foam while on in Europe. It was so cheap at the pharmacy -- about $300 for enough to use it nearly every day for a year -- that I bought a year's supply. Of course I couldn't use my medical insurance (they'd have no idea what it was anyway) but I was happy to just have a chance to buy it.

So far, I've found it to be very helpful for maintaining remission, though I've been fighting a flare recently and switched to the cortifoam for the short-term.
-------
UC for the last ten years
Current Meds: 6MP since 2006, Lialda, Asacol foam, Lomotil
Past Meds: You name it; I've tried it. (Asacol, Colazol, Pentasa, DiPentum, Rowasa, Canasa, Cortenema, sulfasalazine, Cortifoam)
Alternative treatments I have had success with: Acupuncture, Hypnotherapy

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