Certain medications are designed to target specific areas of your colon. I can't comment on the Salofalk but Asacol, depending on the PH level in your colon, can release all the way thru or half way. I am not sure what the PH level has to be but sometime if someone has left sided on down they don't do well on Asacol because the medication doesn't reach all the way. Colazal, which is a basalazide not a mesalamine, is more ideal for left sided - down. Asacol is usually the better choice for Pancolitis.
Mesalamine enemas only reach to the sigmoid colon, maybe a bit higher. But even if it only reaches so high, it can still be beneficial for someone with Pancolitis. Asacol can heal from the top on down and the enema can treat the end section.
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~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Year-round allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis-epidural injections~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-second series starts 2/17, OA in my fingers -Celebrex, Tylonel Arthritis and Voltaren Gel
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Posted 5/29/2009 8:57 PM (GMT -7)
If you have severe left-sided UC, you likely need steroid enemas as minimum treatment. The liquid only reaches as far as the sigmoid colon (same as 5-ASA liquid enema), but with 3+ weeks of use the steroid enemas have a systemic effect that helps the descending colon, too. Mesalamine enemas only have a topical effect-- so oral med is needed to treat inflammation in the descending colon or higher up. ASAs vary in their effect among patients and in the same patient at different stages of treatment. For example, ten yrs ago I achieved remission after 8-10 weeks on mesalamine enemas, but a couple months ago they aggravated a flare so I had to stop them & depend on Colazal capsules, which, thankfully, worked to subdue moderate ulceration in the sigmoid. I agree that if your doctor is "narrow-minded" about meds it could add to your problems. There's a huge range of response to meds among UC patients so it's best to hook up with an IBD-experienced gastro who listens to your complaints and RXes/adjusts meds accordingly and monitors your condition carefully via appropriate scopes/lab tests. / Old Hat (30 yrs with left-sided UC; original Colazal has been my best med to-date, the generic (balzalazide) made me sick)
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