It is interesting. Quite a few pubmed abstracts on mast cells role in IBD e.g. this review article:
Of course, the role of mast cells is far more complex in IBD than histamine, since anti-histamines have no effect against IBD inflammation.
Pancolitis >20 years, allergic to all 5ASAs
Tried everything under the sun (natural and alternative)
Some partial success with TSO but was too expensive to keep up
Remicade Humira, lots of probiotics, entocort, tapering pred again, maybe surgery this year