Does 6mp work for everybody???

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Regular Member

Date Joined Jul 2008
Total Posts : 35
   Posted 6/3/2009 3:02 PM (GMT -6)   
Ive been on 6mp for about 3 months.  I have had an increased dose of 100mg for about 9 weeks still NO progress.  It is very depressing and I'm so over it!  My question is does 6mp work for everybody AND how long ?
Current Meds:
4 Lialda daily
Rowasa nightly

Forum Moderator

Date Joined Apr 2004
Total Posts : 23551
   Posted 6/3/2009 4:06 PM (GMT -6)   
Not one thing works for everyone. There can be varying degree of success with 6mp or Imuran. Some can only have slight improvement while others it can drastically change their life or it can become toxic for a person. So no, it doesn't work for everyone. Sometimes though, some people respond slower then others and I've heard of it taking as long as 6 months or more for it to start working for some people.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-had 2 series of 3, OA-Celebrex, Tylonel Arthritis and Voltaren Gel
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Veteran Member

Date Joined Aug 2008
Total Posts : 5951
   Posted 6/3/2009 4:10 PM (GMT -6)   
     It took three months for it to kick in with the prednisone for me.  It doesn't keep me out of flares though.  The flares seem to be getting closer together hiss.
62 yr old granny. South Jersey
Diagnosed with ulcerative proctitis in 1998 in hospital
Hospitalized (2nd time) in May 2008
Update 11/03/08...finally in remission!!  Hope I don't jinx myself.  Off the prednisone since 11/01/ see if I can stay off for longer than two weeks.  Other meds: 6MP (75 mgm), colazal (6 per day), Benicar and Toprol (high blood pressure meds), Probiotic (2 per day), fish oil capsule and multi-vitamin and calcium with vitamin D.

Regular Member

Date Joined Apr 2009
Total Posts : 55
   Posted 6/4/2009 2:28 AM (GMT 0)   
6mp works for most, though for me its effectiveness was short lived. Please be careful with your dosage as it can cause people to become immuno compromised.

Forum Moderator

Date Joined Feb 2006
Total Posts : 5698
   Posted 6/4/2009 6:54 AM (GMT -6)   

I took it for 1.5 years and never saw improvement.


dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

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