Biologics and Azathioprine

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diaper man
Regular Member


Date Joined May 2009
Total Posts : 122
   Posted 6/3/2009 4:07 PM (GMT -6)   
I just saw this good news in the below article today about using Biologics and Azathioprine (Immuran).  Anybody using these at the same time? Are you getting the same results any sideffects.
 
http://www.medicalnewstoday.com/articles/152422.php 
Diagnosed Crohns/Colitis Jan 2007.  Allergic to 5sa. Currently taking Humira and Hydrocortisone Canasa suppositories
Colits in last part of Colon.  Currently bleeding every bowel movement. 


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3442
   Posted 6/4/2009 7:50 AM (GMT -6)   
I take both a biologic & Imuran- I started the Imuran first, then added Remicade about 3-4 months into things. My GI thought that the Imuran would help prevent antibodies to the Remicade from forming, which is I guess why they put people on both types of drugs. So far so good- while I wouldn't consider myself to be in remission, I'm better than I have been- able to work, go on trips, lead a normal life. Prior to these 2 drugs I was literally chained to my house, unable to go more thatn 30 minutes (on a good day) without a dash to the bathroom. I get labs done every 6 weeks & they all have been looking pretty good. I know the lymphoma risk, but it's quite rare & after long-term use of the 2 drugs together. Not sure what's considered long-term use though, as I've been on the 2 for over 2 years now. If I had to choose one over the other I'd stick with Imuran & drop Remicade, simply becasue Imuran is easier & cheaper to take. I also think it is doing more for me on a day-to-day basis than the Remicade, but I'm loathe to quit Remicade entirely- it's helping somewhat still! My last scope, about a year ago, showed active inflammation still, about 10 inches. I'll probable be getting another scope within the next 6 months or so, & I'm curious to see if things have improved or stayed the same. Or god forbid, gotten worse!
diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
various probiotics
Fiber supplement
 
 
 


diaper man
Regular Member


Date Joined May 2009
Total Posts : 122
   Posted 6/4/2009 9:02 AM (GMT -6)   
Eva, I am glad its working for you. My doc said that there have been 17 cases of Lymphoma out of millions of people using the drugs worlwide. And the chances are slim. If I were to take it, then it would be Humira and Immuran but I am holding off for now. Just started back on Budesonide to see if that can get me back to somewhat normal.
Diagnosed Crohns/Colitis Jan 2007.  Allergic to 5sa. Currently taking Humira and Hydrocortisone Canasa suppositories
Colits in last part of Colon.  Currently bleeding every bowel movement. 


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3442
   Posted 6/4/2009 10:48 AM (GMT -6)   
good luck! I'd like to try Humira myself, if I can get it thru my insurer. My GI would switch me to that in a heartbeat, simply because the Remicade is slowly losing effectiveness. See, my thing is avoiding the steroids- I haven't been on them since February of last year!!!!! After having been on & off prednisone for a year and a half. If things get so bad it's to the point of using them again, I'd most likely opt for surgery. But I'd push HARD for Humira before then! What type of insurance do you have? Are you in a trial for UC, or do you have a Crohns diagnosis? I could probably ask my GI to change my diagnosis to Crohns Colitis, if that would help getting the med covered.
diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade-10mgs/kg- since 4/07
Imuran- 150mgs/day
various probiotics
Fiber supplement
 
 
 


diaper man
Regular Member


Date Joined May 2009
Total Posts : 122
   Posted 6/4/2009 11:56 AM (GMT -6)   
I have pretty good insurance right now. I work for a Medical School. They balk at renewing Humira double dose but approved it. I am not in any trials for UC. They have my diagnoses as Crohns/Colitis or basically I don't think they really know. Most of my symptons are on the UC side. You probably could get your GI to change the diagnoses becuase they probably really don't know anyway. I agree with you on the prednisone, that is why I asked for Budesonide. Surgery is always in the back of my mind. But from what I heard the people that have had it do not regret the surgery.
Diagnosed Crohns/Colitis Jan 2007.  Allergic to 5sa. Currently taking Humira and Hydrocortisone Canasa suppositories.  Budesonide
Colitis in last part of Colon.  Currently bleeding every bowel movement. 

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