bluejean...I don't know if there's a point of no return.....maybe there's been no testing on that part becasue those who have success with 5ASA enemas are able to taper to their maintenance dosage. Some are able to taper off completely and use them for flares and taper then off again. I'm not one since the second year of diagnosis.
I do know of another UCer who sees my doc who was (last year) using the Pentasa enemas nightly for a year and had the OK of my doc to continue to do so (he mentioned that most people would never even want to consider using rectal meds any longer than necessary, but worth a try if she's wanting to do it). I don't know what strength the dosage was or if it even comes in 2g/4g. I've lost touch with her and don't know how she's doing, so can't offer anything more on that.
What I would suggest, however, is to maybe start using the 2g nightly to see if you improve. Maybe 4g is too high for you nightly and you're slightly sensitive to the 5ASA in a high dosage (I'm considering that from your mentioning that the Asacol higher than 6 daily ws too much).
When you insert the med....are you laying on your left side? You might want to sit up or lay on your back to keep most of it lower in the rectum.
*Heather* Status: mild flare enemas tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~UC meds: Asacol (3 x2 daily); Salofalk enemas nightly for flares & taper to maintenance
~Bentylol (dicyclomine) 20mg as needed; Ranitidine (reflux); Effexor XR 75mg(depression); Pulmicort/Airomir (asthma)
~vitamins/minerals/supplements; Probiotics....(Natural Factors Protec, Primadophilus Reuteri Pearls). @ bedtime
~various digestive enzymes as needed
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS" worth it !!!
Post Edited (quincy) : 6/6/2009 11:38:24 PM (GMT-6)