How do mesalamines & basalazide work?

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Regular Member

Date Joined Nov 2008
Total Posts : 339
   Posted 6/14/2009 1:29 PM (GMT -6)   
Though its been nearly 6 months since i have been on mesalamine but i dnt know how it works. What i understand is they heal the irritated part of colon but i also know that these are not treatment developed for UC...i.e not cure for UC OR are they? Is there any medicine which is developed only for UC.
Right now -FLARING (after my Rubella vaccination)
Diagnosed in Jan'2009: Canasa suppositories 1000 nightly - worked for 2 months then re-flare
13 may: canasa 1000 X2 daily for 2 weeks - to start Lialda after 2 weeks if canasa double dose does not work
Lialda X2 started on 30th may.
Symptoms: Mucus, blood, constipated (not always), Lots Gas
Also gifted with Hypothyroid & have calicum deficiency family history!
Also started Probiotic from 23 Mar & fresh Turmeric root from 25 March'09- stopped both on 10th May

Veteran Member

Date Joined Feb 2009
Total Posts : 735
   Posted 6/14/2009 1:44 PM (GMT -6)   
None of them actually heal you of the disease, they are just used to reduce inflammation, so the reason you have to take them drugs forever. They are all break down to 5-ASA (mesalazine), but they use different forms to deliver it to your body. Balsalazide eventually turns into 5-ASA once the bacteria from your colon breaks it down.

I don't know if any were developed specifically for Colitis but as far as I know, all non steroid, non immune suppressant drugs used to treat UC are mesalazine based, and that includes Sulfasalazine.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 6/14/2009 6:53 PM (GMT -6)   
Mesalamines and basalazides do not contain sulfa while sulfasalazine does. Good thing too because I am highly allergic to sulfa! :)

These meds are designed, as Zippy said, to reduce the inflammation and to heal but cure? No, as of now there is no cure. They are not even sure what exactly causes it. And yes, these meds were specifically designed to heal the IBD'er.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Bentyl, Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate ALL mesalamines**~Allergies-Singulair, Zyrtec~Secondary Reynauds Syndrome-'04-Norvasc~Sacroiliitis~bulging and herniated discs C5/C6 & C6/C7~3 epidural injections-had 2 series of 3, OA-Celebrex, Tylonel Arthritis and Voltaren Gel
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Hans C
Regular Member

Date Joined Dec 2006
Total Posts : 89
   Posted 6/15/2009 7:33 AM (GMT -6)   
Though successful surgical removal of the colon can be considered a cure... right?
born 1982  --- diagnosed 2004 (probable left sided)
Pentasa 500mg x 8  daily
Salofalk foam enema (4gm x 1 daily), predsol (half enema daily (20mg/2))
iron (gelfer), triphala 1gm daily (ayurvedic herb) 

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