I have been on Prednisolone (varying doses...currently on 20mg) since Dec last year, and started on Azathioprine nearly 8 weeks ago. The first 2 blood tests after starting came back completely normal, the third I get the results of this Friday. I got the usual side effects of feeling very nauseous etc however they improved after about week 3, theyve since returned - I have only eaten 2 proper meals since last week, have a sore throat most days and I am extremely tired...I've struggled with fatigue a lot but this is like nothing I've ever experienced. MY IBD nurse has started me back on enemas and suppositories and told me to stay at 20mg Pred for the time being.
Maybe this is the Azathioprine working, or maybe I'm just getting the side effects for the moment. But whatever the case, if after 3 months things still havn't settled, my nurse mentioned Methotrexate but I really don't want to take that because of the fertility issues that come with it. (And saying that I don't want to even be taking Azathioprine because of the risks that come with it.)
I'm steroid dependant and feel relatively ok on a high dose, its just so annoying you can't stay on it for very long!!
Anyway, I know I need to give it a few more weeks to see if the Aza will work, but I just wondered what everyone elses experiences have been with Azathioprine and what happened if it didn't kick in?!
22 year old female, from the UK. Diagnosed with Ulcerative Proctitis Jan '08. Hospitalised Jan '09 for 3 days IV Hydrocortisone - had no effect! Hospitalised Feb '09 for 7 days (5 days - IV Hydrocortisone)
Currently taking daily:
20mg Prednisolone tablets, 100mg Azathioprine (started taking 11th May),1g Acetarsol suppository every other night, 1g Mesalazine granules x 2
Motilium (anti sickness), 1.5mg Zopiclone (taken when needed for sleeping), 10mg Citalopram (anti-anxiety/depression), Probiotic Multivitamins